The Value of HCT-ALB in the Early Diagnosis of Sepsis-associated Encephalopathy

Congxin LI; Dapeng ZHANG; Lingjie MU; Jilin YANG; Lihong DONG; Yijie WANG

doi:10.12259/j.issn.2095-610X.S20220901

Volume 43 Issue 9

Sep. 2022

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Congxin LI, Dapeng ZHANG, Lingjie MU, Jilin YANG, Lihong DONG, Yijie WANG. The Value of HCT-ALB in the Early Diagnosis of Sepsis-associated Encephalopathy[J]. Journal of Kunming Medical University, 2022, 43(9): 24-28. doi: 10.12259/j.issn.2095-610X.S20220901

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Congxin LI, Dapeng ZHANG, Lingjie MU, Jilin YANG, Lihong DONG, Yijie WANG. The Value of HCT-ALB in the Early Diagnosis of Sepsis-associated Encephalopathy[J]. Journal of Kunming Medical University, 2022, 43(9): 24-28. doi: 10.12259/j.issn.2095-610X.S20220901

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The Value of HCT-ALB in the Early Diagnosis of Sepsis-associated Encephalopathy

doi: 10.12259/j.issn.2095-610X.S20220901

1.
Dept. of ICU，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan, 650032
2.
Kunming Meizhao Health Examination Center，Kunming Yunnan 650032，China

Received Date: 2022-07-26
Available Online: 2022-09-07
Publish Date: 2022-09-29

Abstract

Abstract

Objective To find simple and reliable clinical quantitative indicators for the early diagnosis of SAE. Methods Seventy-two septic patients who were admitted to ICU from April 2020 to April 2022, including 31 with sepsis encephalopathy （SAE） and 41 without sepsis encephalopathy （Ne-SAE）, were collected. APACHE Ⅱ, SOFA and general data of Patients were recorded, and CLI, HCT-ALB were calculated based on the clinical assays. Plasma was collected using ELISA to detect NT-proCNP, S100A 8, Tau protein and C5a. Results APACHEⅡscore and SOFA score in SAE group were significantly higher compared with the patients in Ne-SAE group （P < 0.05）. Plasma NT-proCNP and S100A8 levels were significantly higher in the patients with SAE than that of the Ne-SAE group （P < 0.05）. There was no significant difference in CLI between SAE group and NE-SAE group. （P = 0.823）. But , the hct-alb was statistically significant between the two groups （P = 0.035）. The roc curve analysis showed: A cutoff value CLI of 11.04 （AUC = 0.478,95% CI 0.340-0.616, P = 0.746） had 46.34% sensitivity and 80.65% specificity in diagnosing SAE. A cutoff value HCT-ALB of 14.85 （AUC = 0.627,95% CI 0.491-0.762, P = 0.017） had 68.27% sensitivity and 67.74% specificity in diagnosing SAE. Conclusion The HCT-ALB level can be useful in the early diagnosis of SAE in patients with sepsis.

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References(19)

References

[1]	Tauber S C,Djukic M,Gossner J,et al. Sepsis-associated encephalopathy and septic encephalitis:An update[J]. Expert Rev Anti Infect Ther,2021,19(2):215-231. doi: 10.1080/14787210.2020.1812384
[2]	Chen J,Shi X,Diao M,et al. A retrospective study of sepsis-associated encephalopathy:Epidemiology,clinical features and adverse outcomes[J]. BMC Emerg Med,2020,20(1):77. doi: 10.1186/s12873-020-00374-3
[3]	Annane D,Sharshar T. Cognitive decline after sepsis[J]. Lancet Respir Med,2015,3(1):61-69.
[4]	Singer M,Deutschman C S,Seymour C W,et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3)[J]. JAMA,2016,315(8):801-810. doi: 10.1001/jama.2016.0287
[5]	Cordemans C,De Laet I,Van Regenmortel N,et al. Fluid management in critically ill patients:The role of extravascular lung water,abdominal hypertension,capillary leak,and fluid balance[J]. Ann Intensive Care,2012,2(Suppl 1):S11-S12.
[6]	Dai D M,Wang D,Hu D,et al. Difference in hematocrit and plasma albumin levels as an additional biomarker in the diagnosis of infectious disease[J]. Arch Med Sci,2020,16(3):522-530. doi: 10.5114/aoms.2019.86898
[7]	Tauber S C,Eiffert H,Bruck W,et al. Septic encephalopathy and septic encephalitis[J]. Expert Rev Anti Infect Ther,2017,15(2):121-132. doi: 10.1080/14787210.2017.1265448
[8]	Pensato U,Muccioli L,Cani I,et al. Brain dysfunction in COVID-19 and CAR-T therapy:Cytokine storm-associated encephalopathy[J]. Ann Clin Transl Neurol,2021,8(4):968-979. doi: 10.1002/acn3.51348
[9]	Gofton T E,Young G B. Sepsis-associated encephalopathy[J]. Nat Rev Neurol,2012,8(10):557-566. doi: 10.1038/nrneurol.2012.183
[10]	Ehler J,Saller T,Wittstock M,et al. Diagnostic value of NT-proCNP compared to NSE and S100B in cerebrospinal fluid and plasma of patients with sepsis-associated encephalopathy[J]. Neurosci Lett,2019,692(10):167-173.
[11]	Heming N,Mazeraud A,Verdonk F,et al. Neuroanatomy of sepsis-associated encephalopathy[J]. Crit Care,2017,21(1):65. doi: 10.1186/s13054-017-1643-z
[12]	Zhang L N,Wang X H,Wu L,et al. Diagnostic and predictive levels of calcium-binding protein A8 and tumor necrosis factor receptor-associated factor 6 in sepsis-associated encephalopathy:A prospective observational study[J]. Chin Med J (Engl),2016,129(14):1674-1681. doi: 10.4103/0366-6999.185860
[13]	Li X L,Xie J F,Ye X Y,et al. Value of cerebral hypoxic-ischemic injury markers in the early diagnosis of sepsis associated encephalopathy in burn patients with sepsis[J]. Zhonghua Shao Shang Za Zhi,2022,38(1):21-28.
[14]	Orhun G,Tüzün E,Özcan P E,et al. Association between inflammatory markers and cognitive outcome in patients with acute brain dysfunction due to sepsis[J]. Noro Psikiyatr Ars,2019,56(1):63-70.
[15]	李永胜,梅华鲜,黄中会,等. 毛细血管渗漏指数对脓毒症危险分层及预后评估的价值[J]. 临床急诊杂志,2017,18(5):362-365. doi: 10.13201/j.issn.1009-5918.2017.05.010
[16]	王晓晖,徐云海,张波. 毛细血管渗漏指数对脓毒症合并ARDS早期诊断及预后的评估价值[J]. 临床急诊杂志,2020,21(5):350-354. doi: 10.13201/j.issn.1009-5918.2020.05.003
[17]	Dai D M,Cao J,Yang H M,et al. Hematocrit and plasma albumin levels difference may be a potential biomarker to discriminate preeclampsia and eclampsia in patients with hypertensive disorders of pregnancy[J]. Clin Chim Acta,2017,464(1):218-222.
[18]	Clyne B,Olshaker J S. The C-reactive protein[J]. J Emerg Med,1999,17(6):1019-25. doi: 10.1016/S0736-4679(99)00135-3
[19]	Pierrakos C,Velissaris D,Bisdorff M,et al. Biomarkers of sepsis:Time for a reappraisal[J]. Crit Care,2020,24(1):287. doi: 10.1186/s13054-020-02993-5

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