The Role of Maternal Serum MMPs and SAA in the Pathogenesis of Preterm Premature Rupture of Membranes

Sainan LI; Wenjin QI; Raoyang KE; Rong HUANG; Guangqiong YANG

doi:10.12259/j.issn.2095-610X.S20220905

Volume 43 Issue 9

Sep. 2022

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Sainan LI, Wenjin QI, Raoyang KE, Rong HUANG, Guangqiong YANG. The Role of Maternal Serum MMPs and SAA in the Pathogenesis of Preterm Premature Rupture of Membranes[J]. Journal of Kunming Medical University, 2022, 43(9): 29-33. doi: 10.12259/j.issn.2095-610X.S20220905

Citation:

Sainan LI, Wenjin QI, Raoyang KE, Rong HUANG, Guangqiong YANG. The Role of Maternal Serum MMPs and SAA in the Pathogenesis of Preterm Premature Rupture of Membranes[J]. Journal of Kunming Medical University, 2022, 43(9): 29-33. doi: 10.12259/j.issn.2095-610X.S20220905

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The Role of Maternal Serum MMPs and SAA in the Pathogenesis of Preterm Premature Rupture of Membranes

doi: 10.12259/j.issn.2095-610X.S20220905

Dept. of Obstetrics，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2022-06-08
Available Online: 2022-09-07
Publish Date: 2022-09-29

Abstract

Abstract

Objective To investigate the relationships of matrix metalloproteinase-1 （MMP-1）, matrix metalloproteinase-3 （MMP-3）, matrix metalloproteinase-9 （MMP-9） and serum amyloid A （SAA） with the premature rupture of membranes. Methods Thirty cases of premature rupture of fetal membranes, 30 cases of full-term premature rupture of fetal membranes and 30 cases of full-term pregnancies were chosen as controls. The levels of MMP-1, MMP-3, MMP-9 and SAA in the peripheral blood of the three groups of pregnant women were measured by ELISA. The placental tissues of the three groups of pregnant women were examined pathologically to determine the presence of histological chorioamnionitis. Results （1） The levels of MMP-1 and SAA of PPROM and PROM groups were significantly higher than those of the control group （P < 0.05）. After the comparison, MMP-1 and SAA of the PPROM group were significantly more than those of the PROM group （P < 0.05）. However, the content of MMP-3 in PPROM group was significantly higher than that in PROM group and the control group （P < 0.05）, but there was no significant difference in the concentration between PROM group and the control group （P＞0.05）. There was no significant difference in the concentration of MMP-9 among the three groups （P > 0.05）. （2） 70% （21/30） in the PROM group, 33.3% （10/30） in the PROM group and 33.3% （10/30） in the control group. The histological positivity rate of placenta in the PPROM group was elevated compaired with that in the PROM and control groups, and the difference was statistically significant （ χ² = 10.841, P < 0.05）. There was no significant difference between the PROM and control groups （P > 0.05）. Conclusion Serum MMP-1, MMP-3 and SAA are closely associated with the premature rupture of membranes complicated by early chorioamnionitis.
- Metal matrix proteins,
- Serum amyloid A,
- Preterm premature rupture of membranes,
- Chorioamnionitis,
- Premature delivery

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References(20)

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