Volume 43 Issue 9
Sep.  2022
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Lingjun SHEN, Lin WANG, Zhiqiang MA, Xing LIU, Haiwen LI, Ge WANG, Wenming LI, Pengju LUO. Immunological Characteristics of Patients with Active and Nonactive Pulmonary Tuberculosis[J]. Journal of Kunming Medical University, 2022, 43(8): 122-126. doi: 10.12259/j.issn.2095-610X.S20220821
Citation: Chen WANG, Sha LI, Boxue ZHANG, Jinhua HE. Effect of VitD Supplementation on the Improvement of Autoimmune Thyroiditis in Childbearing Age Females[J]. Journal of Kunming Medical University, 2022, 43(9): 135-140. doi: 10.12259/j.issn.2095-610X.S20220907
shu

Effect of VitD Supplementation on the Improvement of Autoimmune Thyroiditis in Childbearing Age Females

doi: 10.12259/j.issn.2095-610X.S20220907
  • 1.

    Dept. of Endocrinology, Tangshan Workers' Hospital , Tangshan Heibei 063000

  • 2.

    Dept. of Endocrinology, The 2nd Hospital of Shijiazhuang City, Shijiazhuang Heibei 050000, China

  • Received Date: 2022-06-26
    Available Online: 2022-09-08
  • Publish Date: 2022-09-29
    Abstract
  •   Objective  To investigate the effects of vitamin D supplementation on thyroid function, autoimmune antibody and serum 25 （OH） D levels in female patients with autoimmune thyroiditis （AT） in the reproductive age.   Methods   94 childbearing age females with AT and admitted to the department of endocrinology of our hospital from January 2019 to August 2021 were enrolled as subjects. According to random number table method, they were randomly assigned to two groups, the control group （n = 47） and the study group （n = 47）, and the parallel control were conducted. All the subjects received the instruction of life style and diet style, the study group received the oral Thyroid hormone and Vitamin D therapy, while the control group only received the oral Thyroid hormone therapy. Thereafter, serum Thyroid hormone levels （FT3, TSH and FT4）, thyroid autoantibodies （TRAb, TPO-Ab） and 25 （OH） D were measured and compared between the two groups at different stages.   Results  （1）Thyroid function: Compared with the situation before the treatment, serum FT3, TSH and FT4 were improved to varying degrees in 2 groups after 6 months of treatment （P < 0.01）, the serum TSH content in the study group was apparently higher than that in the control group [（2.34±0.33） μIU/mL VS （2.19±0.36） μIU/mL], and the results were statistically significant （P < 0.05）. （2） Thyroid autoimmune antibody: After 6 months of treatment, serum TRAb and TPO-Ab levels in the study group were evidently better, compared to the control group [（0.56±0.38） U/L VS （4.35±1.71） U/L; （35.71±8.85） U/mL VS （77.41±19.91） U/mL] （P < 0.01）, lower than TRAb and TPO-Ab levels before treatment and 3 months after the treatment （P < 0.01）. （3） Serum 25 （OH）D level: Compared with the situation before the treatment, the serum 25 （OH）D level of the study group increased significantly after 6 months of treatment （P < 0.05）, evidently better than that in the control group [（61.91±8.73） ng/mL VS （10.79±3.16） ng/mL] （P < 0.05）.   Conclusion  Vitamin D supplementation can significantly improve serum 25 （OH） D level and autoimmune antibody titer in patients with autoimmune thyroiditis in the short term （6 months）, but the effect on Thyroid hormone levels is not obvious and it can be used as an adjunctive treatment for autoimmune thyroiditis patientswith low vitamin D level.
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    • References(27)
  • [1]
    Ahmed Abdel Khalek Abdel Razek,Sieza Samir Abd Allah,Amr Abd El-Hamid El-Said. Role of diffusion-weighted magnetic resonance (MR) imaging in differentiation between graves' disease and painless thyroiditis[J]. Pol J Radiol,2017,15(82):536-541.
    [2]
    柯文才,毛会军,顾芸霞,等. 维生素D在NOD. H-2~(h4)小鼠实验性自身免疫性甲状腺炎中的作用研究[J]. 检验医学与临床,2021,18(3):289-292. doi: 10.3969/j.issn.1672-9455.2021.03.001
    [3]
    娜仁其木格,李冬梅,忻荣荣,等. 低滴度TRAb原发性甲状腺毒症患者TRAb水平与甲状腺131I摄取率的相关性研究[J]. 国际内分泌代谢杂志,2020,40(3):4.
    [4]
    赵慧,陈文文,朱丽萍,等. 1,25(OH)_2D_3通过抑制TLR2/NF-κB信号通路保护实验性自身免疫性甲状腺炎大鼠甲状腺功能研究[J]. 中国比较医学杂志,2022,32(3):78-86. doi: 10.3969/j.issn.1671-7856.2022.03.000
    [5]
    Keiichi Kamijo. Painless thyroiditis with thyrotropin receptor-blocking and receptor-stimulating autoantibodies[J]. Intern Med,2019,58(21):3121-3123. doi: 10.2169/internalmedicine.3212-19
    [6]
    HOLICK M F. The vitamin D deficiency pandemic:Approaches for diagnosis,treatment and prevention[J]. Rev Endocr Metab Disord,2017,18(2):153-165. doi: 10.1007/s11154-017-9424-1
    [7]
    赵雅冬,刘海霞,程丽霞. 1型糖尿病合并自身免疫性甲状腺疾病与维生素D的研究进展[J]. 当代医学,2021,27(32):189-192. doi: 10.3969/j.issn.1009-4393.2021.32.076
    [8]
    Krysiak R,Szkróbka W,Okopień B. The effect of vitamin D on thyroid autoimmunity in levothyroxine-treated women with hashimoto's thyroiditis and normal vitamin D status[J]. Exp Clin Endocrinol Diabetes,2017,125(4):229-233. doi: 10.1055/s-0042-123038
    [9]
    汪湲,康志强,张小芳,等. 自身免疫性甲状腺炎患者血浆中Th1/Th2细胞及甲状腺自身抗体水平变化及临床意义[J]. 实用医院临床杂志,2020,17(1):154-157.
    [10]
    夏丽,周颖,董明慧,等. 多囊卵巢综合征患者血清生长激素释放肽,摄食抑制因子1,内脂素水平与自身免疫性甲状腺炎的相关性分析[J]. 中国性科学,2021,30(6):52-55.
    [11]
    沈姿容,袁文文. 超声检查在判断自身免疫性甲状腺炎患者甲状腺功能中的临床价值[J]. 健康研究,2018,38(2):208-210,219.
    [12]
    王峰. 甲状腺摄碘率测定在Graves'病和亚急性甲状腺炎鉴别诊断中的价值分析[J]. 中国保健营养,2016,26(20):4.
    [13]
    向茜,王玉明,杨艳润,等. 维生素 D 受体基因 ApaI 、 FokI 、TaqI 、 Tru9I 位点单核苷酸多态性与桥本氏甲状腺炎的相关性[J]. 昆明医科大学学报,2018,39(4):88-94. doi: 10.3969/j.issn.1003-4706.2018.04.019
    [14]
    夏伟,张春艳,李蓬秋,等. 妊娠期桥本甲状腺炎患者 25羟维生素 D 水平变化及其影响因素分析[J]. 中国全科医学,2018,21(36):4476-4479.
    [15]
    王卓然,苏鑫洪,贺晓生. 关于维生素 D 与桥本甲状腺炎的研究进展[J]. 转化医学电子杂志,2018,5(5):44-47. doi: 10.12095/j.issn.2095-6894.2018.05.010
    [16]
    周景英,龙崇荣,唐能华. 维生素 D 治疗对桥本甲状腺炎患者甲状腺自身抗体的影响[J]. 现代医药卫生,2018,34(11):1656-1658. doi: 10.3969/j.issn.1009-5519.2018.11.017
    [17]
    尚敬,于璐,李全忠,等. 桥本甲状腺炎甲状腺功能减退患者血清 1,25- 二羟维生素 D3 及白细胞介素 -8 水平变化及意义[J]. 中华实用诊断与治疗杂志,2018,32(6):575-577.
    [18]
    Papadimitriou D T,Marakaki C,Fretzayas A,et al. Negativation of type 1 diabetes‐associated autoantibodies to glutamic acid decarboxylase and insulin in children treated with oral calcitriol (口服骨化三醇治疗维持儿童1型糖尿病相关的谷氨酸脱羧酶与胰岛素自身抗体阴性)[J]. Journal of Diabetes,2013,5(3):344-348.
    [19]
    刘思琪,王苏,吴亚平,等. 补充维生素D治疗对自身免疫性甲状腺炎患者甲状腺自身抗体水平影响的Meta分析[J]. 东南大学学报(医学版),2021,40(2):207-213.
    [20]
    Islam N,Shukla N,Chamadia A,et al. Effect of all previous dental treatment on the current oral health related quality of life in geriatric patients[J]. IP Annals of Prosthodontics and Restorative Dentistry,2020,6(1):22-30. doi: 10.18231/j.aprd.2020.007
    [21]
    Khozam Sabah A,Sumaili Abdulhadi M,Alflan Mohammed A,et al. Association between vitamin D deficiency and autoimmune thyroid disorder:A systematic review[J]. Cureus,2022,14(6):e25869-e25869.
    [22]
    何静,张春辉,李慧,等. 维生素D缺乏治疗对自身免疫性甲状腺疾病影响的研究[J]. 齐齐哈尔医学院学报,2020,41(9):1117-1118.
    [23]
    Ragusa F,Fallahi P,Elia G,et al. Hashimotos' thyroiditis:Epidemiology,pathogenesis,clinic and therapy[J]. Best Pract Res Clin Endocrinol Metab,2019,33(6):101367. doi: 10.1016/j.beem.2019.101367
    [24]
    Ralli M,Angeletti D,Fiore M,et al. Hashimoto's thyroiditis:An update on pathogenic mechanisms,diagnostic protocols,therapeutic strategies,and potential malignant transformation[J]. Autoimmun Rev,2020,19(10):102649. doi: 10.1016/j.autrev.2020.102649
    [25]
    Guo Q,Wu Y,Hou Y,et al. Cytokine secretion and pyroptosis of thyroid follicular cells mediated by enhanced NLRP3,NLRP1,NLRC4,and AIM2 inflammasomes are associated with autoimmune thyroiditis[J]. Front Immunol,2018,4(9):1197.
    [26]
    杨雪威,王思源,徐锦江,等. 运动联合维生素D对实验性自身免疫性甲状腺炎小鼠的保护作用[J]. 东南大学学报(医学版),2019,38(2):323-327. doi: 10.3969/j.issn.1671-6264.2019.02.021
    [27]
    Sahebari M,Nabavi N,Salehi M. Correlation between serum 25(OH)D values and lupus disease activity:An original article and a systematic review with meta-analysis focusing on serum VitD confounders[J]. Lupus,2014,23(11):1164-1177. doi: 10.1177/0961203314540966
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      沈阳化工大学材料科学与工程学院 沈阳 110142

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