Comparison the Clinical Outcomes of Progestin-Primed Ovarian Stimulation during Follicular Period and Mild-stimulation in Patients with Diminished Ovarian Reserve

Zexing YANG; Ya WEN; Cunmei SU; Huawei WANG; Meng RAO; Yuhang ZHENG; Limei HE

doi:10.12259/j.issn.2095-610X.S20221211

Volume 43 Issue 12

Dec. 2022

Turn off MathJax

Article Contents

Abstract

References

Relative Articles

Article Navigation > Journal of Kunming Medical University > 2022 > 43(12): 53-57

Zexing YANG, Ya WEN, Cunmei SU, Huawei WANG, Meng RAO, Yuhang ZHENG, Limei HE. Comparison the Clinical Outcomes of Progestin-Primed Ovarian Stimulation during Follicular Period and Mild-stimulation in Patients with Diminished Ovarian Reserve[J]. Journal of Kunming Medical University, 2022, 43(12): 53-57. doi: 10.12259/j.issn.2095-610X.S20221211

Citation:

Zexing YANG, Ya WEN, Cunmei SU, Huawei WANG, Meng RAO, Yuhang ZHENG, Limei HE. Comparison the Clinical Outcomes of Progestin-Primed Ovarian Stimulation during Follicular Period and Mild-stimulation in Patients with Diminished Ovarian Reserve[J]. Journal of Kunming Medical University, 2022, 43(12): 53-57. doi: 10.12259/j.issn.2095-610X.S20221211

Citation:

Zexing YANG, Ya WEN, Cunmei SU, Huawei WANG, Meng RAO, Yuhang ZHENG, Limei HE. Comparison the Clinical Outcomes of Progestin-Primed Ovarian Stimulation during Follicular Period and Mild-stimulation in Patients with Diminished Ovarian Reserve[J]. Journal of Kunming Medical University, 2022, 43(12): 53-57. doi: 10.12259/j.issn.2095-610X.S20221211

PDF( 636 KB)

Comparison the Clinical Outcomes of Progestin-Primed Ovarian Stimulation during Follicular Period and Mild-stimulation in Patients with Diminished Ovarian Reserve

doi: 10.12259/j.issn.2095-610X.S20221211

1.
Dept. of Reproductive Genetics，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Yunnan Provincial Key Laboratory of Birth Regulation and Healthy Birth of Ethnic Minorities，Western Key Laboratory of Healthy Birth before Pregnancy，Kunming Yunnan 650032
3.
Wenzhou Center for Disease Control and Prevention，Wenzhou Zhejiang 325000
4.
Dept. of Epidemiology，School of Public Health, Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2022-05-10
Publish Date: 2022-12-25

Abstract

Abstract

Objective To compare the clinical outcomes of PPOS protocal and mild-stimulation protocal in patients with diminished ovarian reserve function during assisted reproduction and pregnancy. Methods Patients with DOR who underwent the first and second generation of test-tube babies（IVF/ICSI） in the First Affiliated Hospital of Kunming Medical University from April 2021 to April 2022 were retrospectively analyzed. A total of 294 cycles were included and divided into 2 groups（group A: PPOS group, group B: mild-stimulation group）. The medication, embryo status and pregnancy outcomes were compared between the two groups. Results Initiation dose of Gn, total Gn dose, HCG dose on trigger day in group A were significantly higher than those in group B（P < 0.05）; LH on HCG day in group A was lower than that in group B（ P < 0.05）. The number of eggs, embryos and high quality embryos in group A were higher than those in group B（ P < 0.05）. Conclusion The clinical outcomes of the PPOS group were better than the mild-stimulation group.
- IVF/ICSI,
- Diminished ovarian reservee,
- Mild stimulation protocol,
- PPOS protocal

FullText(HTML)

References(19)

References

[1]	张婉玉,李静,张凌寒,等. 卵巢储备功能下降的不孕症女性抗苗勒管激素与体重指数的相关性研究[J]. 生殖医学杂志,2021,30(4):441-446. doi: 10.3969/j.issn.1004-3845.2021.04.005
[2]	刘亚丽,于莎,陈秋菊,等. 克罗米芬联合高孕激素促排卵抑制早发LH峰的临床结局研究[J]. 生殖与避孕,2016,36(4):263-269.
[3]	Chen M,Wu Y,Huang X,et al. Embryo incubation by time-lapse systems versus conventional incubators in Chinese women with diminished ovarian reserve undergoing IVF/ICSI:A study protocol for a randomised controlled trial[J]. BMJ Open,2020,10(11):038657.
[4]	Pelosi E,Simonsick E,Forabosco A,et al. Dynamics of the ovarian reserve and impact of genetic and epidemiological factors on age of menopause[J]. Biol Reprod,2015,92(5):130.
[5]	Greenead,Patounakis G,Segars J H. Genetic associations with diminished ovarian reserve:A systematic review of the literature[J]. J Assist Reprod Genet,2014,31(8):935-946. doi: 10.1007/s10815-014-0257-5
[6]	Yu R,Jin H,Huang X F,et al. Comparison of modified agonist,mild-stimulation and antagonist protocols for in vitro fertilization in patients with diminished ovarian reserve[J]. J Int Med Res,2018,46(6):2327-2337. doi: 10.1177/0300060518770346
[7]	Kuang Y,chen Q,FU Y,et al. Medroxyprogesterone acetate is an effective oral alternative for preventing premature luteinizing hormone surges in women undergoing controlled ovarian hyperstimulation for in vitro fertilization[J]. Fertil Steril,2015,104(1):62-70.e3. doi: 10.1016/j.fertnstert.2015.03.022
[8]	Wang Y,Kuang Y,Chen Q,et al. Gonadotropin-releasing hormone antagonist versus progestin for the prevention of premature luteinising hormone surges in poor responders undergoing in vitro fertilisation treatment:Study protocol for a randomised controlled trial[J]. Trials,2018,19(1):455. doi: 10.1186/s13063-018-2850-x
[9]	刘洋,南燕,陈帆,等. 不同促排卵方案在高龄卵巢储备功能减退患者中的应用效果比较[J]. 新乡医学院学报,2020,37(5):465-470.
[10]	曾倩凌,燕怡,李艳萍,等. 高孕激素状态下促排卵与微刺激方案在卵巢储备功能下降患者中的临床结局及经济效益比较[J]. 中国临床研究,2020,33(7):908-912. doi: 10.13429/j.cnki.cjcr.2020.07.010
[11]	Ubaldi F M,Cimadomo D,Vaiarelli A,et al. Advanced maternal age in IVF:Still a challenge? The present and the future of its treatment[J]. Front Endocrinol (Lausanne),2019,20(10):94.
[12]	Drakopoulos P, Bardhi E, Boudry L, et al. Update on the management of poor ovarian response in IVF: The shift from Bologna criteria to the Poseidon concept[J]. Ther Adv Reprod Health, 2020 , 31（14）: 2633494120941480.
[13]	Liu X,Li T,Wang B,et al. Mild stimulation protocol vs conventional controlled ovarian stimulation protocol in poor ovarian response patients:A prospective randomized controlled trial[J]. Arch Gynecol Obstet,2020,301(5):1331-1339. doi: 10.1007/s00404-020-05513-6
[14]	Casano S,Guidetti D,Patriarca A,et al. MILD ovarian stimulation with GnRH-antagonist vs. long protocol with low dose FSH for non-PCO high responders undergoing IVF:A prospective,randomized study including thawing cycles[J]. J Assist Reprod Genet,2012,29(12):1343-1351. doi: 10.1007/s10815-012-9863-2
[15]	沈秀,李颂军,周睿琼,等. 高孕激素下促排卵方案用于 FSH 升高DOR患者的临床效果观察[J]. 生殖医学杂志,2017,26(4):351-356. doi: 10.3969/j.issn.1004-3845.2017.04.012
[16]	中华医学会妇产科学分会绝经学组. 早发性卵巢功能不全的激素补充治疗的专家共识[J]. 中华妇产科杂志,2016,51(12):881-886.
[17]	Li X,Zhang X,Cai J,et al. Granulosa cells apoptosis and follicular fluid hormones:Comparison of progestin-primed ovarian stimulation versus GnRH antagonist protocols[J]. Gynecol Endocrinol,2021,37(7):609-613. doi: 10.1080/09513590.2020.1822802
[18]	温国亮. 不孕症患者冷冻胚胎移植后妊娠结局的影响因素[J]. 当代医学杂志,2022,28(21):129-131.
[19]	Salehnia M,Zavareh S. The effects of progesterone on oocyte maturation and embryo development[J]. Int J Fertil Steril,2013,7(2):74-81.

Relative Articles(20)

Relative Articles

[1]	Fen TENG, Bo TIAN, Chongxi LI, Yongmei JIN, Haiyun CHEN, Jun LIU. Real-World Clinical Efficacy and Safety of Bictegravir/Emtricitabine/Tenofovir Alafenamide （BIC/FTC/TAF） Single-Tablet Regimen. Journal of Kunming Medical University, 2024, 45(4): 74-80. doi: 10.12259/j.issn.2095-610X.S20240411
[2]	Chenxi LI, Zhuocen ZHA, Na LI, Lin LUO, Yang YANG, Wenlin CHEN. Selection of Intensive Adjuvant Therapy for Triple-positive Breast Cancer. Journal of Kunming Medical University, 2023, 44(10): 180-188. doi: 10.12259/j.issn.2095-610X.S20231020
[3]	Bo TIAN, Chongxi LI, Yongmei JIN, Wei GUAN, Haiyun CHEN, Jun LIU. Use and Replacement of Treatment Regimens for AIDS Patients on Antiretroviral Therapy. Journal of Kunming Medical University, 2023, 44(5): 162-167. doi: 10.12259/j.issn.2095-610X.S20230508
[4]	Jiang ZHANG, Xi-juan ZHAO, Jiang WU, Yan LIU, Li-juan LI, Ye CHEN. Application of Family Empowerment Nursing Intervention Program in Patients with Lung Cancer Undergoing Radiotherapy. Journal of Kunming Medical University, 2021, 42(12): 169-176. doi: 10.12259/j.issn.2095-610X.S20211242
[5]	Li Li Ping , Zhao Hong Chao , Zhang Yun Zhu , Li Jun . . Journal of Kunming Medical University, 2019, 40(08): 47-51.
[6]	Zhang Wen . The Clinical Analysis of Three Kinds of Treatment Regimens for 300 Cases of Bacterial Vaginal Disease. Journal of Kunming Medical University,
[7]	Xu Hui Ling . . Journal of Kunming Medical University,
[8]	Guo Pei Yu . . Journal of Kunming Medical University,
[9]	Shan Da Yan . . Journal of Kunming Medical University,
[10]	Zhang Ming . . Journal of Kunming Medical University,
[11]	Zhou Jiu Peng . . Journal of Kunming Medical University,
[12]	Wan Yun Yan . . Journal of Kunming Medical University,
[13]	Yue Cheng Shan . . Journal of Kunming Medical University,
[14]	Wang Jue . . Journal of Kunming Medical University,
[15]	Zhang Ren Fa . . Journal of Kunming Medical University,
[16]	Li Dong Ya . . Journal of Kunming Medical University,
[17]	Yang Ai Ling . . Journal of Kunming Medical University,
[18]	. Clinical Study of Kangai Injection Combined with FORFIRI Chemotherapy in the Treatment of 30 Cases of Advanced Colon Cancer. Journal of Kunming Medical University,
[19]	. Investigating Optimal Types of Iatrogenic Bile Duct Injury——A Retrospective Analysis of Clinical Treatment With 52 Cases. Journal of Kunming Medical University,
[20]	Chen Shi Ling . . Journal of Kunming Medical University,

Supplements(0)

Cited By

Cited by

Periodical cited type(2)

1.	李玢，罗萌萌，张丹丹，张娜娜. 促性腺激素释放激素拮抗剂方案与高孕激素状态下促排卵方案对卵巢储备功能减退患者体外受精-胚胎移植助孕结局的影响. 中国性科学. 2024(04): 53-57 .
2.	林冰，文琴，梅凤琦，张兰琴，黄俊花，庞颖仪，梁洁珩，梁丽能，何嘉欣，陈姚，甄国志. 不同类型孕激素的高孕激素状态下促排卵方案在高龄卵巢储备功能减退患者中的应用研究. 生殖医学杂志. 2024(10): 1282-1287 .