Efficacy of Conventional Ultrasound and Contrast-enhanced Ultrasound in Preoperative Diagnosis of Lateral Cervical Lymph Node Metastasis from Papillary Thyroid Carcinoma

Jianfei LU; Rui BU; Xiaoyan LIU; Xing ZHANG; Yu DING; Ran ZHANG

doi:10.12259/j.issn.2095-610X.S20221214

Volume 43 Issue 12

Dec. 2022

Turn off MathJax

Article Contents

Abstract

References

Relative Articles

Article Navigation > Journal of Kunming Medical University > 2022 > 43(12): 75-80

Wenxiu XU, Xiaofeng MO, Xiangmin YANG, Silu YANG, Fan WU, Te LI. Application of Logistic Regression and Decision Tree Model in Prediction of Adverse Reactions of Iodinated Contrast Medium[J]. Journal of Kunming Medical University, 2024, 45(9): 70-75. doi: 10.12259/j.issn.2095-610X.S20240911

Citation:

Jianfei LU, Rui BU, Xiaoyan LIU, Xing ZHANG, Yu DING, Ran ZHANG. Efficacy of Conventional Ultrasound and Contrast-enhanced Ultrasound in Preoperative Diagnosis of Lateral Cervical Lymph Node Metastasis from Papillary Thyroid Carcinoma[J]. Journal of Kunming Medical University, 2022, 43(12): 75-80. doi: 10.12259/j.issn.2095-610X.S20221214

Citation:

PDF( 2140 KB)

Efficacy of Conventional Ultrasound and Contrast-enhanced Ultrasound in Preoperative Diagnosis of Lateral Cervical Lymph Node Metastasis from Papillary Thyroid Carcinoma

doi: 10.12259/j.issn.2095-610X.S20221214

1.
Dept. of Ultrasound
2.
Dept. of cardiology，The 2nd Affiliated Hospital of Kunming Medical University, Kunming Yunnan 650101，China

Received Date: 2022-08-02
Available Online: 2022-12-05
Publish Date: 2022-12-25

Abstract

Abstract

Objective To investigate the ultransonic characteristics of conventional ultrasound （US）combined with Contrast-enhanced ultrasound （CEUS） in the pre-operative diagnosis effectiveness of lateral cervical lymph node metastasis （LCLNM）from papillary thyroid carcinoma （PTC）, and to evaluate its efficacy in preoperative diagnosis of PTC lateral cervical lymph node metastasis. Methods A total of 80 patients who received PTC surgery and lateral cervical lymph node dissection in the Second Affiliated Hospital of Kunming Medical University were selected, and 126 lymph node ultrasonography data were obtained. Postoperative pathology confirmed that 81 lymph nodes were metastatic PTC and 45 lymph nodes were non-metastatic. The ultrasonographic features of lymph node metastasis were observed by conventional ultrasound （US） and contrast-enhanced ultrasound （CEUS）. Compared with the pathological results, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of US, CEUS and combined application in the preoperative diagnosis of LCLNM in PTC patients were calculated. Results The ultrasonographic features of metastatic lymph nodes were mostly lymphatic portal disappearance or deviation. Cortical echo was non-uniform hypoecho, internal mass hyperecho and calcification, blood flow types were mostly peripheral type and mixed type, and blood flow grades were mostly Adler grade 2 and grade 3; compared with the non-metastatic group, the difference was statistically significant （P < 0.05）. The ultrasonographic characteristics of metastatic lymph nodes detected by CEUS were mostly centriotype and type Ⅱ, followed by type Ⅲ. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of the combination of US and CEUS were superior to those of US or CEUS alone in the diagnosis of PTC lateral cervical lymph node metastasis. Conclusion Preoperative conventional ultrasound combined with CEUS can improve the diagnostic efficacy of lateral cervical lymph node metastasis from PTC.
- Ultrasonography,
- Contrast-enhanced ultrasound,
- Papillary thyroid carcinoma,
- Lateral cervical lymph node metastasis

FullText(HTML)

References(22)

References

[1]	Siegel R L,Miller K D,Fuchs H E,et al. Cancer statistics,2021[J]. CA Cancer J Clin.,2021,71(1):7-33. doi: 10.3322/caac.21654
[2]	Kim Y,Roh J L,Gong G,et al. Risk factors for lateral neck recurrence of N0/N1a papillary thyroid cancer[J]. Ann Surg Oncol,2017,24(12):3609-3616. doi: 10.1245/s10434-017-6057-2
[3]	Haugen B R,Alexander E K,Bible K C,et al. 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer:The American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer[J]. Thyroid,2016,26(1):1-133. doi: 10.1089/thy.2015.0020
[4]	Wu J H,Zeng W,Wu R G,et al. Comparison of ultrasonography and CT for determining the preoperative benign or malignant nature of thyroid nodules:Diagnostic performance according to calcification[J]. Technol Cancer Res Treat,2020,19(1):1-6.
[5]	Brauckhoff K,Biermann M. Multimodal imaging of thyroid cancer[J]. Curr Opin Endocrinol Diabetes Obes,2020,27(5):335-344. doi: 10.1097/MED.0000000000000574
[6]	Poanta L,Serban O,Pascu I,et al. The place of CEUS in distinguishing benign from malignant cervical lymph nodes:A prospective study[J]. Med Ultrason,2014,16(1):7-14. doi: 10.11152/mu.2014.2066.161.lp1os2
[7]	Cui Q L,Yin S S,Fan Z H,et al. Diagnostic value of contrast-enhanced ultrasonography and time-intensity curve in differential diagnosis of cervical metastatic and tuberculous lymph nodes[J]. J Ultrasound Med,2018,37(1):83-92. doi: 10.1002/jum.14311
[8]	Grégoire V,Ang K,Budach W,et al. Delineation of the neck node levels for head and neck tumors:A 2013 update. DAHANCA,EORTC,HKNPCSG,NCIC CTG,NCRI,RTOG,TROG consensus guidelines[J]. Radiother Oncol,2014,110(1):172-181. doi: 10.1016/j.radonc.2013.10.010
[9]	Adler D D,Carson P L,Rubin J M,Quinn-Reid D. Doppler ultrasound color flow imaging in the study of breast cancer:Preliminary findings[J]. Ultrasound Med Biol,1990,16(6):553-559. doi: 10.1016/0301-5629(90)90020-D
[10]	张雪云. 超声造影及弹性成像在浅表淋巴结病变鉴别诊断中的价值[D]. 兰州: 兰州大学硕士学位论文, 2019.
[11]	Luster M,Aktolun C,Amendoeira I,et al. European perspective on 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer:Proceedings of an interactive international symposium[J]. Thyroid,2019,29(1):7-26. doi: 10.1089/thy.2017.0129
[12]	周倩,许萍. 超声评估甲状腺癌颈部转移淋巴结的研究进展[J]. 中国医学影像技术,2019,35(11):1752-1756. doi: 10.13929/j.1003-3289.201906103
[13]	Zhao B H,Huang Z H,Huang Y C,et al. Preliminary study of superselective lymph node dissection in regional lateral cervical lymph node metastasis of papillary thyroid carcinoma[J]. Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology],2021,43(4):484-489.
[14]	任玲,费翔,张艳,等. 高帧率超声造影对颈部浅表淋巴结病变良恶性的鉴别诊断[J]. 中国医学影像学杂志,2021,29(10):989-992,997. doi: 10.3969/j.issn.1005-5185.2021.10.007
[15]	王晓荣,梁奎,艾迪拜·木合买提,等. 剪切波弹性成像及超声造影鉴别颈部不典型反应性增生淋巴结及淋巴瘤的价值[J]. 中国医学影像学杂志,2020,28(8):566-570. doi: 10.3969/j.issn.1005-5185.2020.08.002
[16]	何守伟,王知力. 恶性浅表淋巴结病变的常规超声及超声造影特征[J]. 中国医学影像学杂志,2021,29(1):9-13. doi: 10.3969/j.issn.1005-5185.2021.01.003
[17]	卜锐,杨娜,夏春娟,等. 高频超声术前诊断甲状腺乳头状癌患者颈部转移性淋巴结[J]. 中国医学影像技术,2019,35(1):55-58. doi: 10.13929/j.1003-3289.201803009
[18]	王磊,李海,唐嘉阅,等. 不同病理性钙化类型甲状腺乳头状癌微血管密度及淋巴结转移比较研究[J]. 肿瘤研究与临床,2018,30(8):531-535. doi: 10.3760/cma.j.issn.1006-9801.2018.08.006
[19]	田菊,勇强,郑超,等. 甲状腺结节微小强回声与组织沙粒体的相关性分析[J]. 中国超声医学杂志,2020,36(4):302-305. doi: 10.3969/j.issn.1002-0101.2020.04.004
[20]	Machado M R,Tavares M R,Buchpiguel C A,et al. Ultrasonographic evaluation of cervical lymph nodes in thyroid cancer[J]. Otolaryngol Head Neck Surg,2017,156(2):263-271.
[21]	任玲,罗渝昆. 经静脉超声造影在浅表淋巴结诊断中的应用[J]. 中国医学影像学杂志,2019,27(8):626-629.
[22]	张琦,庄连婷,李家兴,等. 常规超声联合超声造影对颈部实性淋巴结良恶性的鉴别诊断[J]. 中国医学影像学杂志,2021,29(1):14-18.

Relative Articles(20)

Relative Articles

[1]	, . . Journal of Kunming Medical University, 2024, 45(1B): 7-8.
[2]	Lin WEI, Mei ZHU, Hailin ZHANG, Yuran FENG, Xi CHEN, Bailing WU, Yang YANG. Value of Binary Logit Regression Model Based on FNA-Tg and Serum Tg for Determining Lymph Node Metastasis or Recurrence of Thyroid Cancer. Journal of Kunming Medical University, 2023, 44(2): 102-107. doi: 10.12259/j.issn.2095-610X.S20230219
[3]	Yan SHEN, Yongfeng LI, Chunhua XIAO, Hong LI, Wei YANG, Shengning ZHANG, Yanqiong LV, Wandong YANG, Shilan. DING. Application of Multimodal Ultrasound in Post-operative Monitoring of Transplanted Livers by Donors after the Brain Death. Journal of Kunming Medical University, 2022, 43(9): 90-95. doi: 10.12259/j.issn.2095-610X.S20220917
[4]	Wen ZHAO, Tengfei KE, Xingyue HU, Renjie ZHAO. Value of Dual-energy CT Spectrum Curve from Primary Tumor in Prediction of Central Occult Lymph Node Metastasis in Papillary Thyroid Cancer. Journal of Kunming Medical University, 2022, 43(10): 74-78. doi: 10.12259/j.issn.2095-610X.S20221028
[5]	Hailin ZHANG, Mei ZHU, Yang YANG, Lin WEI, Xi CHEN, Bailing WU. Clinical Value of Ultrasound-guided FNA and FNA-TG in Identification of Lymph Node Metastasis of Papillary Thyroid Carcinoma. Journal of Kunming Medical University, 2022, 43(12): 105-110. doi: 10.12259/j.issn.2095-610X.S20221220
[6]	Ju-xiang MA, Yong-hong MA, Shan-shan GAO, Jue WU, Min ZHU, Zhen-ling DUAN. Value of Intravenous Contrast-enhanced Ultrasound in Differential Diagnosis of Adenomyosis and Uterine Fibroids. Journal of Kunming Medical University, 2020, 41(11): 114-118. doi: 10.12259/j.issn.2095-610X.S20201109
[7]	Zou Hua Li . . Journal of Kunming Medical University, 2019, 40(08): 63-66.
[8]	Hua Jie , Ruan Ling Yu , Ma Ding Qian , Zuo Xiao Shuang , Xiang Run Qing , Fang Shan Dan , Fan Yuan . Thyroid Papillary Carcinoma Cells TPC-1 Apoptosis Induced by Ursolic Acid. Journal of Kunming Medical University, 2018, 39(01): 10-15.
[9]	Li Lei , Yang Jie , Wang Wei Lin , Wang Hu . The Correlation between the Location of Thyroid Papillary Microcarcinoma and Cervical Lymph Node Metastasis. Journal of Kunming Medical University, 2018, 39(06): 91-95.
[10]	Chen Hai Tao , Yang Li Chun , Hai Sai Ping , Luo Xiao Mao . Value of Contrast Enhanced Ultrasonography in Catheter Drainage. Journal of Kunming Medical University, 2018, 39(04): 62-65.
[11]	Nian Ying Hua , Shen Ruo Xia , Chuan Zhi Rui , Qu Yin Xi , Yang Li Chun . . Journal of Kunming Medical University, 2017, 38(05): 87-90.
[12]	Wu Jue . Diagnostic Value of Contrast-enhanced Ultrasonography in Differentiating Benign and Malignant Tumor of Pelvic Cavity. Journal of Kunming Medical University,
[13]	Hai Sai Ping , Yang Li Chun . A Retrospective Analysis of Ultrasonographic Misdiagnosis of Thyroid Multiple Nodules With Thyroid Carcinoma. Journal of Kunming Medical University, 2016, 37(11): 89-92.
[14]	Dai Rui . . Journal of Kunming Medical University,
[15]	Yang Yang . . Journal of Kunming Medical University,
[16]	Sun Rui Mei . . Journal of Kunming Medical University,
[17]	Huang Yan Ling . . Journal of Kunming Medical University,
[18]	Xia Yao You . . Journal of Kunming Medical University,
[19]	Lu Jian Fei . . Journal of Kunming Medical University,
[20]	Chen Hai Tao . . Journal of Kunming Medical University,

Supplements(0)

Cited By

Cited by

Periodical cited type(4)

1.	谭荣欣. 非生物型人工肝治疗肝功能衰竭的疗效观察. 现代诊断与治疗. 2024(17): 2636-2637+2640 .
2.	杨军杰，钟炎平，毛静，刘鑫华，李姗，刘园园，雷旭，雷飞飞，雷雨，郭鹏，胡波，刘志新，谭华炳. 血浆置换联合双重血浆分子吸附治疗对乙型肝炎病毒相关慢加急性肝功能衰竭肝细胞再生的影响. 中国医学创新. 2023(05): 63-69 .
3.	乔艳，刘传苗，李冬冬，赵文，巴志伟，汪小玲，张妹，郭普. 人工肝治疗肝衰竭患者医院感染危险因素分析及预测模型构建. 右江民族医学院学报. 2023(03): 458-462 .
4.	乔艳，刘传苗，汪小玲，张妹，李冬冬，郭普. 人工肝治疗肝衰竭病人医院感染调查及危险因素分析. 蚌埠医学院学报. 2023(06): 758-761 .