Correlation between Serum RANKL，OPG，FGF23 and Renal Function and Calcium-phosphorus Metabolism in Patients with Chronic Renal Disease

Dexin MENG; Xiaoping ZHOU; Hu MENG; Hui HE; Lingli XIONG; Xiaomi MO

doi:10.12259/j.issn.2095-610X.S20230213

Volume 44 Issue 2

Feb. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(2): 98-101

Dexin MENG, Xiaoping ZHOU, Hu MENG, Hui HE, Lingli XIONG, Xiaomi MO. Correlation between Serum RANKL，OPG，FGF23 and Renal Function and Calcium-phosphorus Metabolism in Patients with Chronic Renal Disease[J]. Journal of Kunming Medical University, 2023, 44(2): 98-101. doi: 10.12259/j.issn.2095-610X.S20230213

Citation:

Dexin MENG, Xiaoping ZHOU, Hu MENG, Hui HE, Lingli XIONG, Xiaomi MO. Correlation between Serum RANKL，OPG，FGF23 and Renal Function and Calcium-phosphorus Metabolism in Patients with Chronic Renal Disease[J]. Journal of Kunming Medical University, 2023, 44(2): 98-101. doi: 10.12259/j.issn.2095-610X.S20230213

Citation:

Dexin MENG, Xiaoping ZHOU, Hu MENG, Hui HE, Lingli XIONG, Xiaomi MO. Correlation between Serum RANKL，OPG，FGF23 and Renal Function and Calcium-phosphorus Metabolism in Patients with Chronic Renal Disease[J]. Journal of Kunming Medical University, 2023, 44(2): 98-101. doi: 10.12259/j.issn.2095-610X.S20230213

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Correlation between Serum RANKL，OPG，FGF23 and Renal Function and Calcium-phosphorus Metabolism in Patients with Chronic Renal Disease

doi: 10.12259/j.issn.2095-610X.S20230213

Dept. of Nephrology，The Affiliated Hospital of Kunming University of Science and Technology，the First people’s Hospital of Yunnan Province，Kunming Yunnan 650032，China

Received Date: 2022-12-14
Available Online: 2023-01-31
Publish Date: 2023-02-25

Abstract

Abstract

Objective To analyze the correlation between serum receptor activator of NF- κ B ligand （RANKL）, osteoprotegerin （OPG）, fibroblast growth factor 23 （FGF23） with renal function and calcium and phosphorus metabolism in patients with chronic kidney disease （CKD）. Methods A total of 62 patients who met the diagnostic criteria of CKD in our hospital from January 2021 to February 2022 were enrolled as the research group, and 26 healthy persons were included in the control group. Renal function and calcium and phosphorus metabolism were measured, and serum levels of RANKL, OPG and FGF23 were measured by enzyme-linked immunosorbent assay （Elisa）. Results The serum levels of RANKL, OPG and FGF23 in the research group were significantly increased, and the serum levels of RANKL, OPG and FGF23 in the CKD5 stage group were higher than the CKD2-3 stage group and the CKD4 stage group. Correlation analysis showed that the serum levels of RANKL, OPG and FGF23 were negatively correlated with eGFR , serum RANKL levels were positively correlated with PTH, serum FGF23 levels were positively correlated with PTH and P levels, and negatively correlated with Ca. Conclusions The levels of serum RANKL, OPG and FGF23 are increasing with the progression of CKD disease. Serum RANKL and FGF23 are sensitive indicators for early detection of calcium and phosphorus metabolism disorders in patients with CKD.
- Chronic kidney disease,
- RANKL,
- OPG,
- FGF23

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References(10)

References

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