Research Progress of Autophagy in the Development and Treatment of Bladder Cancer

Shi CHEN; Shi FU; Zhiyong TAN; Jiansong WANG; Haifeng WANG

doi:10.12259/j.issn.2095-610X.S20230503

Volume 44 Issue 5

May 2023

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2023 > 44(5): 168-174

Shi CHEN, Shi FU, Zhiyong TAN, Jiansong WANG, Haifeng WANG. Research Progress of Autophagy in the Development and Treatment of Bladder Cancer[J]. Journal of Kunming Medical University, 2023, 44(5): 168-174. doi: 10.12259/j.issn.2095-610X.S20230503

Citation:

Shi CHEN, Shi FU, Zhiyong TAN, Jiansong WANG, Haifeng WANG. Research Progress of Autophagy in the Development and Treatment of Bladder Cancer[J]. Journal of Kunming Medical University, 2023, 44(5): 168-174. doi: 10.12259/j.issn.2095-610X.S20230503

Citation:

PDF( 585 KB)

Research Progress of Autophagy in the Development and Treatment of Bladder Cancer

doi: 10.12259/j.issn.2095-610X.S20230503

Dept. of Urology，The 2nd Affiliated Hospital of Kunming Medical University，Yunnan Urinary System Disease Clinical Medical Center，Kunming Yunnan 650101，China

Received Date: 2023-01-01
Available Online: 2023-05-12
Publish Date: 2023-05-25

Abstract

Abstract

Autophagy is a self-digestive process of cells degrading intracellular substances through lysosomes and is considered to be an important protection mechanism for tumors to maintain survival under stress conditions. A large number of evidence shows that autophagy is a double-edged sword, which can suppress the occurrence of tumors and promote the survival and growth of tumors by different signaling pathways. Therefore, more and more scholars believe that autophagy is expected to become a new strategy for tumor treatment. This paper summarizes the biological behavior of autophagy regulation of bladder cancer invasion, metastasis, and the latest progress in the treatment of bladder cancer and provides new ideas for the development and treatment of autophagy-targeted antitumor drugs.
- Bladder cancer,
- Autophagy,
- Tumor therapy,
- Drug resistance

FullText(HTML)

References(38)

References

[1]	Siegel R L,Miller K D,Jemal A. Cancer statistics,2020[J]. CA:A Cancer Journal for Clinicians,2020,70(1):7-30. doi: 10.3322/caac.21590
[2]	Sung H,Ferlay J,Siegel R L,et al. Global cancer statistics 2020: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA:A Cancer Journal for Clinicians,2021,71(3):209-249. doi: 10.3322/caac.21660
[3]	Birgisdottir A B,Johansen T. Autophagy and endocytosis - interconnections and interdependencies[J]. Journal of Cell Science,2020,133(10):1-16.
[4]	Rakesh R,Priyadharshini L C,Sakthivel K M,et al. Role and regulation of autophagy in cancer[J]. Biochimica Et Biophysica Acta Molecular Basis of Disease,2022,1868(7):1-22.
[5]	Li W,He P,Huang Y,et al. Selective autophagy of intracellular organelles: Recent research advances[J]. Theranostics,2021,11(1):222-256. doi: 10.7150/thno.49860
[6]	Kim J,Kundu M,Viollet B,et al. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1[J]. Nature Cell Biology,2011,13(2):132-141. doi: 10.1038/ncb2152
[7]	MizushimaI N,Komatsu M. Autophagy: Renovation of cells and tissues[J]. Cell,2011,147(4):728-741. doi: 10.1016/j.cell.2011.10.026
[8]	Li X,He S,Ma B. Autophagy and autophagy-related proteins in cancer[J]. Molecular Cancer,2020,19(1):1-16. doi: 10.1186/s12943-019-1085-0
[9]	Towers C G,Wodetzki D,Thorburn A. Autophagy and cancer: Modulation of cell death pathways and cancer cell adaptations[J]. The Journal of Cell Biology,2020,219(1):1-15.
[10]	Ishaq M,Ojha R,Sharma A P,et al. Autophagy in cancer: Recent advances and future directions[J]. Seminars In Cancer Biology,2020,66(11):171-181.
[11]	Lee C H,Yu H S. Role of mitochondria,ROS,and DNA damage in arsenic induced carcinogenesis[J]. Frontiers in Bioscience,2016,8(2):312-320. doi: 10.2741/s465
[12]	Denisenko T V,Gogvadze V,Zhivotovsky B. Mitophagy in carcinogenesis and cancer treatment[J]. Discover Oncology,2021,12(1):1-11. doi: 10.1007/s12672-021-00395-9
[13]	Chao H,Deng L,Xu F,et al. RAB14 activates MAPK signaling to promote bladder tumorigenesis[J]. Carcinogenesis,2019,40(11):1341-1351. doi: 10.1093/carcin/bgz039
[14]	Jin H,Ma J,Xu J,et al. Oncogenic role of MIR516A in human bladder cancer was mediated by its attenuating PHLPP2 expression and BECN1-dependent autophagy[J]. Autophagy,2021,17(4):840-854. doi: 10.1080/15548627.2020.1733262
[15]	Tong H,Yin H,Hossain M A,et al. Starvation-induced autophagy promotes the invasion and migration of human bladder cancer cells via TGF-β1/Smad3-mediated epithelial-mesenchymal transition activation[J]. Journal of Cellular Biochemistry,2019,120(4):5118-5127. doi: 10.1002/jcb.27788
[16]	Zhang H H,Huang Z X,Zhong S Q,et al. MiR-21 inhibits autophagy and promotes malignant development in the bladder cancer T24 cell line[J]. International Journal of Oncology,2020,56(4):986-998.
[17]	Gubbiotti M A,Buraschi S,Kapoor A,et al. Proteoglycan signaling in tumor angiogenesis and endothelial cell autophagy[J]. Seminars in Cancer Biology,2020,62(1):1-8.
[18]	Li D,Jiao W,Liang Z,et al. Variation in energy metabolism arising from the effect of the tumor microenvironment on cell biological behaviors of bladder cancer cells and endothelial cells[J]. Bio Factors,2020,46(1):64-75. doi: 10.1002/biof.1568
[19]	Li X,Wei Z,Yu H,et al. Secretory autophagy-induced bladder tumour-derived extracellular vesicle secretion promotes angiogenesis by activating the TPX2-mediated phosphorylation of the AURKA-PI3K-AKT axis[J]. Cancer Letters,2021,523(12):10-28.
[20]	Lin J F,Lin Y C,Tsai T F,et al. Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells[J]. Drug Design,Development and Therapy,2017,11(5):1517-1533.
[21]	Li K,Chen X,Liu C,et al. Pirarubicin induces an autophagic cytoprotective response through suppression of the mammalian target of rapamycin signaling pathway in human bladder cancer cells[J]. Biochemical and Biophysical Research Communications,2015,460(2):380-385. doi: 10.1016/j.bbrc.2015.03.042
[22]	Ojha R,Singh S K,Bhattacharyya S. JAK-mediated autophagy regulates stemness and cell survival in cisplatin resistant bladder cancer cells[J]. Biochimica Et Biophysica Acta,2016,1860(11):2484-2497. doi: 10.1016/j.bbagen.2016.07.021
[23]	Ojha R,Jha V,Singh S K. Gemcitabine and mitomycin induced autophagy regulates cancer stem cell pool in urothelial carcinoma cells[J]. Biochimica Et Biophysica Acta,2016,1863(2):347-359. doi: 10.1016/j.bbamcr.2015.12.002
[24]	Zhu J,Huang G,Hua X,et al. CD44s is a crucial ATG7 downstream regulator for stem-like property,invasion,and lung metastasis of human bladder cancer (BC) cells[J]. Oncogene,2019,38(17):3301-3315. doi: 10.1038/s41388-018-0664-7
[25]	Yamamoto K,Venida A,Yano J,et al. Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I[J]. Nature,2020,581(7806):100-105. doi: 10.1038/s41586-020-2229-5
[26]	Alissafi T,Hatzioannou A,Mintzas K,et al. Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells[J]. The Journal of Clinical Investigation,2018,128(9):3840-3852. doi: 10.1172/JCI120888
[27]	Zhu J,Li Y,Luo Y,et al. A feedback loop formed by ATG7/autophagy,FOXO3a/miR-145 and PD-L1 regulates stem-like properties and invasion in human bladder cancer[J]. Cancers,2019,11(3):1-19.
[28]	Yin Z,Li J,Kang L,et al. Epigallocatechin-3-gallate induces autophagy-related apoptosis associated with LC3B II and Beclin expression of bladder cancer cells[J]. Journal of Food Biochemistry,2021,45(6):1-8.
[29]	Zhang Y,He N,Zhou X,et al. Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells[J]. Aging,2021,13(17):21251-21267. doi: 10.18632/aging.203441
[30]	Berning L,Schlutermann D,Friedrich A,et al. Prodigiosin sensitizes sensitive and resistant urothelial carcinoma cells to cisplatin treatment[J]. Molecules,2021,26(5):1-17.
[31]	Hung S Y,Chen W F,Lee Y C,et al. Rhopaloic acid A induces apoptosis,autophagy and MAPK activation through ROS-mediated signaling in bladder cancer[J]. Phytomedicine:International Journal of Phytotherapy and Phytopharmacology,2021,92(11):1-15.
[32]	Jimenez-Guerrero R,Gasca J,Flores M L,et al. Obatoclax and paclitaxel synergistically induce apoptosis and overcome paclitaxel resistance in urothelial cancer cells[J]. Cancers,2018,10(12):1-17.
[33]	Jin Y Y,Tong S Q,Tong M. Erdafitinib exerts the anticancer effect on urothelial carcinoma via induction of authophagy[J]. Die Pharmazie,2020,75(5):195-197.
[34]	Yu G,Jia Z,Dou Z. miR-24-3p regulates bladder cancer cell proliferation,migration,invasion and autophagy by targeting DEDD[J]. Oncology Reports,2017,37(2):1123-1131. doi: 10.3892/or.2016.5326
[35]	Zeng L P,Hu Z M,Li K,et al. miR-222 attenuates cisplatin-induced cell death by targeting the PPP2R2A/Akt/mTOR Axis in bladder cancer cells[J]. Journal of Cellular and Molecular Medicine,2016,20(3):559-567. doi: 10.1111/jcmm.12760
[36]	Zhang Z,Jia J P,Zhang Y J,et al. Long noncoding RNA ADAMTS9-AS2 inhibits the proliferation,migration,and invasion in bladder tumor cells[J]. OncoTargets and Therapy,2020,13(7):7089-7100.
[37]	Shang C,Zhu Y L,Li Y Q,et al. Autophagy promotes oncolysis of an adenovirus expressing apoptin in human bladder cancer models[J]. Investigational New Drugs,2021,39(4):949-960. doi: 10.1007/s10637-021-01073-x
[38]	Zhao Z,Zhang P,Li W,et al. Pegylated recombinant human arginase 1 induces autophagy and apoptosis via the ROS-activated AKT/mTOR pathway in bladder cancer cells[J]. Oxidative Medicine and Cellular Longevity,2021,2021(3):1-13.

Relative Articles(20)

Relative Articles

[1]	Yuqin LIU, Mingying YANG, Liufang WANG, Siya XIA, Danna LI, Xijuan ZHAO, Ya WANG. Development of a Patient-reported Outcome Scale For Bladder Cancer and Test of Reliability and Validity. Journal of Kunming Medical University, 2024, 45(7): 183-190. doi: 10.12259/j.issn.2095-610X.S20240727
[2]	Yijun AN, Lidan YU, Meisu ZHAO, Dongmei MA, Chunhua YANG, Yao KONG. The Application of Prognostic Model of Lysosomal Related Genes in Bladder Cancer. Journal of Kunming Medical University, 2024, 45(5): 66-72. doi: 10.12259/j.issn.2095-610X.S20240510
[3]	Jun XIE, Shaoyou LIU, Hongjin SHI, Qiuyu MAO, Hong YANG. Enhanceing Effect of EZH2 Inhibitors in Combination with GC Chemotherapeutic Agents in Bladder Cancer. Journal of Kunming Medical University, 2023, 44(10): 67-76. doi: 10.12259/j.issn.2095-610X.S20231017
[4]	Ziwei ZHANG, Jialin ZHENG, Xiaoyu XU, Hong WANG. Metformin Inhibits high Glucose-induced Vascular Smooth Muscle Cells Proliferation by Promoting Autophagy via AMPK/PPAR-γ. Journal of Kunming Medical University, 2023, 44(10): 60-66. doi: 10.12259/j.issn.2095-610X.S20231026
[5]	Xuesha ZHANG, Jie ZHOU, Cailin LI, Dingyu WU, Fang PENG. Effects of Periplaneta americana Extract on Autophagy and Invasive Metastasis of Subcutaneous Transplanted Hepatocellular Carcinoma in Nude Mice. Journal of Kunming Medical University, 2023, 44(10): 39-46. doi: 10.12259/j.issn.2095-610X.S20231018
[6]	Chenchen LIANG, Jianpeng GAO. MSCs Promote Autophagy to Alleviate Liver Injury in NASH by Regulating AMPK/mTOR Axis. Journal of Kunming Medical University, 2023, 44(7): 162-167. doi: 10.12259/j.issn.2095-610X.S20230728
[7]	Xiaomei JIN, Jieyan HE, Jichang SHI, Hui XING, Hong WANG, Ju ZHANG, Lijuan DONG, Lihua HUANG, Min CHEN, Zhijuan CHEN, Huichao CHEN. Virus Genotypes and Drug Resistance among HIV/AIDS Patients before Antiretroviral Therapy in Dali Bai Autonomous Prefecture in 2018. Journal of Kunming Medical University, 2023, 44(11): 152-157. doi: 10.12259/j.issn.2095-610X.S20231123
[8]	Yixuan CHEN, Lin WANG, Xiuhong XIA, Zaikun PENG, Yi DING, Runjiao SHI, Xuefen LEI. Research Progress on the Mechanisms of Autophagy in Hepatocellular Carcinoma. Journal of Kunming Medical University, 2023, 44(4): 159-164. doi: 10.12259/j.issn.2095-610X.S20230416
[9]	Jun GU, Zexi HE, Ting LUAN, Haifeng WANG, Jiansong WANG, Mingxia DING. Research Progress of Exosomes-derived Long Non-coding RNA in Bladder Cancer. Journal of Kunming Medical University, 2022, 43(1): 150-156. doi: 10.12259/j.issn.2095-610X.S20220110
[10]	Zhi YAN, Jingang HAO, Yunyun SHANG. Value of VI-RADS Scoring System in Precision Treatment of Bladder Cancer. Journal of Kunming Medical University, 2022, 43(3): 74-79. doi: 10.12259/j.issn.2095-610X.S20220322
[11]	Yong-jun LIU, Yin WANG, Mei YANG, E-gao YIN, Ting LI, Zhao-xing DONG. The Effect of Hydrogen-Regulated Autophagy on Pulmonary Fibrosis in Paraquat Poisoned Rats. Journal of Kunming Medical University, 2021, 42(9): 1-6. doi: 10.12259/j.issn.2095-610X.S20210918
[12]	Wen-jing SUN, Man-ting HU, Na LI, Fei GE, Wen-lin CHEN, Yang LIU. Progress in Clinical Research on Drug Resistance and Reversal of Endocrine Therapy in Breast Cancer. Journal of Kunming Medical University, 2021, 42(7): 143-149. doi: 10.12259/j.issn.2095-610X.S20210724
[13]	Yang Can , Gong Yu Hang , Wang Hai Feng , Li Hai Hao , Liu Jing Yu , Wang Wei , Wang Jian Song , Zuo Yi Gang , Chen Jian , Zhan Hui , Ding Ming Xia . The Research of Monoclonal Antibody KMP1 Inhibited Bladder Cancer EJ Cell Lines Growth and Metastasis in Vivo. Journal of Kunming Medical University, 2018, 39(05): 1-6.
[14]	Lei Yu Ying , Gao Jie , Wang Rao Xiang , Chuan Li Xue , Hao Jin Gang . Value of Diffusion Weighted Imaging in the Diagnosis of Bladder Cancer. Journal of Kunming Medical University, 2017, 38(07): 136-139.
[15]	Huang Zhen Hua , Shi Xin , Wang Hui Tao , Zhang Jing Song , Wang Guang , Hao Jin Gang , Liu Jian He . Application Value of DWI in Diagnosis of T Staging of Bladder Cancer. Journal of Kunming Medical University, 2016, 37(12): 67-71.
[16]	Lian Yang Yang . . Journal of Kunming Medical University,
[17]	Wang Yang . . Journal of Kunming Medical University,
[18]	Zeng Hong Jing . . Journal of Kunming Medical University,
[19]	Ma Zhen . . Journal of Kunming Medical University, 2012, 33(07): 1-1.
[20]	. . Journal of Kunming Medical University,