Volume 44 Issue 5
May  2023
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Article Navigation >  Journal of Kunming Medical University  > 2023  >  44(5): 95-101
Xibing Zhang, Ling Niu, Fang Liu, Jianghua Ran. The Effects of Caloric Restriction and Intermittent Fasting on Inflammation and Metabolic Diseases[J]. Journal of Kunming Medical University, 2024, 45(12): 1-9. doi: 10.12259/j.issn.2095-610X.S20241201
Citation: Chenglin YANG, Jie HU, Jing WANG, Minhua WANG, Ling HUANG. Clinical Correletions between Helper T Cells 17，Regulatory T Cells and Chronic Actinic Dermatitis[J]. Journal of Kunming Medical University, 2023, 44(5): 95-101. doi: 10.12259/j.issn.2095-610X.S20230511
shu

Clinical Correletions between Helper T Cells 17，Regulatory T Cells and Chronic Actinic Dermatitis

doi: 10.12259/j.issn.2095-610X.S20230511
  • 1.

    Dept.of Internal Medicine，Dali Nursing Vocational College，Dali Yunnan，671000

  • 2.

    Dept.of Dermatology，Traditional Chinese Hospital of LuAn，Luan Anhui 237000

  • 3.

    Dept.of Dermatology，Jinshan Hospital of Fudan University，Shanghai 200540

  • 4.

    Dept.of Dermatology，The 1st Affiliated Hospital of Dali University，Dali Yunnan 671001，China

  • Received Date: 2023-01-16
    Available Online: 2023-05-11
  • Publish Date: 2023-05-25
    Abstract
  •   Objective  To investigate the the possible roles of helper T cells 17 （Thl7 cells） and regulatory T cells （Treg cells） of chronic actinic dermatitis.   Methods  The percentages of Th17 cells and Treg cells in CD4+ T cells in peripheral blood of 25 CAD patients and 20 healthy volunteers were detected by flow cytometry, and the expression of IL-17 and Foxp3 in skin lesions of 25 patients with chronic actinic dermatitis and 10 healthy people were detected by immunohistochemistry.   Results  Compared with the healthy volunteers, Th17 cells in CAD patients were significantly more than those in volunteers; Treg cells in CAD patients were significantly less than those in volunteers; Th17/Treg in CAD patients was significantly higher than that in volunteers and all the differences were statistically significant （P < 0.05）. The correlation coefficients of Th17 cells and EASI scores showed that there was a positive correlation between them （P < 0.05）; the correlation coefficients of Treg cells and EASI scores showed that there was a negative correlation between them. The expression of IL-17 in lesions of CAD group was higher than that of healthy control group and the difference was statistically significant （P < 0.05）. There was no significant difference in the expression of Foxp3 in the skin compared with the healthy control group （P > 0.05）.   Conclusion  The imbalance of Th17/Treg in patients with CAD leads to the development of immune response to pro-inflammatory, which may be an important pathogenesis of CAD.
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  • [1]
    王海波,刘海春,王振清. 慢性光化性皮炎患者外周血T细胞亚群水平变化及意义[J]. 海南医学院学报,2015,21(1):71-72,76. doi: 10.13210/j.cnki.jhmu.20141016.003
    [2]
    Norris P G,Hawk J L. Chronic actinic dermatitis. A unifying concept[J]. Arch Dermatol,1990,126(3):376-378. doi: 10.1001/archderm.1990.01670270108018
    [3]
    农祥,孙思昊,何黎. 敏感性皮肤与光敏性皮肤病的鉴别[J]. 皮肤科学通报,2020,37(6):581-584.
    [4]
    Hanifin J M,Thurston M,Omoto M,et al. The eczema area and severity index (EASI): Assessment of reliability in atopic dermatitis[J]. Experimental Dermatology,2001,10(1):11-18. doi: 10.1034/j.1600-0625.2001.100102.x
    [5]
    陈浩,邓丹琪,周晓鸿,等. Tcl/Tc2失衡和慢性光线性皮炎发病的相关性研究[J]. 中华皮肤科杂志,2005,38(10):628-630.
    [6]
    Milner J D,Brenchley J M,Laurence A,et al. Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome[J]. Nature,2008,452(7188):773-776. doi: 10.1038/nature06764
    [7]
    Ma C S,Chew G Y,Simpson N,et al. Deficiency of Thl7 cells in hyper IgH syndrome due to mutations in STAT3[J]. J Exp Med,2008,205(7):1551-1557. doi: 10.1084/jem.20080218
    [8]
    Chang S H,Dong C. IL-17F; Regulation,signaling and function in inflammation[J]. Cytokine,2009,46(1):7-11. doi: 10.1016/j.cyto.2008.12.024
    [9]
    Iwakura Y,Ishigame H,Saijo S,et al. Functional specialization of interleukin-17 family members[J]. Immunity,2011,34(2):149-162. doi: 10.1016/j.immuni.2011.02.012
    [10]
    Baliwag J,Barnes D H,Johnston A. Cytokines in psoriasis[J]. Cytokine,2015,73(2):342-350. doi: 10.1016/j.cyto.2014.12.014
    [11]
    Buckner J H. Mechanisms of impaired regulation by CD4+ CD25+ FOXP3+ regulatory T cells in human autoimmune diseases[J]. Nature Reviews Immunology,2010,10(12):849. doi: 10.1038/nri2889
    [12]
    Huang Hui,Lu Zhiwei,Jiang Chunguo,et al. Imbalance between Th17 and regulatory T-Cells in sarcoidosis[J]. International Journal of Molecular Sciences,2013,14(11):21463-21473. doi: 10.3390/ijms141121463
    [13]
    Alexander Y,Rudensky. Regulatory T cells and Foxp3[J]. Immunological Reviews,2011,241(1):260-268. doi: 10.1111/j.1600-065X.2011.01018.x
    [14]
    Shimon,Sakaguchi,Tomoyuki,et al. Regulatory T cells and immune tolerance[J]. Cell,2008,133(5):775-787. doi: 10.1016/j.cell.2008.05.009
    [15]
    He J,Zhang X,Wei Y,et al. Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus[J]. Nature Medicine,2016,22(9):991. doi: 10.1038/nm.4148
    [16]
    Park J S,Kwok S K,Lim M A,et al. STA-21,a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells,inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental model of rheumatoid arthritis[J]. Arthritis Rheumatol,2014,66(4):918-929. doi: 10.1002/art.38305
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