Association of Single Nucleotide Polymorphisms of Calcium Sensitive Receptor Gene with Calcium Nephrolithiasis and Hypercalciuria in Chinese Dai Population

Ji LI; Kunbin KE; Baiyu ZHANG; Yidao LIU; Jing BAI; Tao DONG; Zhencheng WANG; Deqiang QIN; Mengyue WANG; Hao LI

doi:10.12259/j.issn.2095-610X.S20230520

Volume 44 Issue 5

May 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(5): 72-80

Ji LI, Kunbin KE, Baiyu ZHANG, Yidao LIU, Jing BAI, Tao DONG, Zhencheng WANG, Deqiang QIN, Mengyue WANG, Hao LI. Association of Single Nucleotide Polymorphisms of Calcium Sensitive Receptor Gene with Calcium Nephrolithiasis and Hypercalciuria in Chinese Dai Population[J]. Journal of Kunming Medical University, 2023, 44(5): 72-80. doi: 10.12259/j.issn.2095-610X.S20230520

Citation:

Ji LI, Kunbin KE, Baiyu ZHANG, Yidao LIU, Jing BAI, Tao DONG, Zhencheng WANG, Deqiang QIN, Mengyue WANG, Hao LI. Association of Single Nucleotide Polymorphisms of Calcium Sensitive Receptor Gene with Calcium Nephrolithiasis and Hypercalciuria in Chinese Dai Population[J]. Journal of Kunming Medical University, 2023, 44(5): 72-80. doi: 10.12259/j.issn.2095-610X.S20230520

Citation:

Ji LI, Kunbin KE, Baiyu ZHANG, Yidao LIU, Jing BAI, Tao DONG, Zhencheng WANG, Deqiang QIN, Mengyue WANG, Hao LI. Association of Single Nucleotide Polymorphisms of Calcium Sensitive Receptor Gene with Calcium Nephrolithiasis and Hypercalciuria in Chinese Dai Population[J]. Journal of Kunming Medical University, 2023, 44(5): 72-80. doi: 10.12259/j.issn.2095-610X.S20230520

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Association of Single Nucleotide Polymorphisms of Calcium Sensitive Receptor Gene with Calcium Nephrolithiasis and Hypercalciuria in Chinese Dai Population

doi: 10.12259/j.issn.2095-610X.S20230520

1.
Dept.of Urinary Surgery，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Dept.of Urinary Surgery ，Yunnan Dehong People’s Hospital，Dehong Yunnan 678400
3.
Dept.of Urinary Surgery ，Mangshi People’s Hospital， Dehong Yunnan 678400，China

Received Date: 2023-01-05
Available Online: 2023-05-13
Publish Date: 2023-05-25

Abstract

Abstract

Objective To study the association of CaSR gene polymorphism with calcium nephrolithiasis and hypercalciuria in Chinese Dai population. Methods The Dai patients with calcium containing renal calculi in Dehong Prefecture, Yunnan Province, China were selected as the experimental group, and the healthy Dai people in Dehong Prefecture, Yunnan Province were taken as the control group. The venous blood was drawn for the determination of the three SNP loci rs7652589, rs1801725, and rs1042636 of the CaSR gene. The subjects in the stone group were tested for 24-hour urine calcium value, and the gene correlation was analyzed. Results There was a statistical difference between the homozygous AA gene and AA+GG gene at rs7652589 locus in the occurrence of calcium nephrolithiasis （P < 0.05）. The 24 h urine calcium value of the GG genotype with rs1042636 locus was significantly different from that of the AA based and AG genotype （P < 0.05）. There was a significant difference in 24 h urine calcium between those with GG genotype at rs7652589 locus and those with AA and AG genotype （P < 0.05） Conclusion The rs7652589 polymorphism on the CaSR gene in the Dai population in China is related to the occurrence of calcium nephrolithiasis and hypercalciuria. The GG gene at rs1042636 is related to the occurrence of hypercalciuria in the Dai population. The GG gene at rs7652589 may be a candidate gene for the occurrence of hypercalciuria leading to calcium nephrolithiasis in this ethnic group.
- Calcium sensitive receptor,
- Calcium nephrolithiasis,
- Single nucleotide polymorphism,
- Hypercalciuria

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References(37)

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