Chemical Compounds Isolated from <i>Pleione Bulbocodioides</i> and Their Bioactive Activities

Xiaorong ZHOU; Meijun YANG; Yuena YANG; Mingxin XU; Yaping CHEN; Huimin WANG; Meihong LI; Yupeng LI

doi:10.12259/j.issn.2095-610X.S20230528

Volume 44 Issue 5

May 2023

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Xiaorong ZHOU, Meijun YANG, Yuena YANG, Mingxin XU, Yaping CHEN, Huimin WANG, Meihong LI, Yupeng LI. Chemical Compounds Isolated from Pleione Bulbocodioides and Their Bioactive Activities[J]. Journal of Kunming Medical University, 2023, 44(5): 1-5. doi: 10.12259/j.issn.2095-610X.S20230528

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Xiaorong ZHOU, Meijun YANG, Yuena YANG, Mingxin XU, Yaping CHEN, Huimin WANG, Meihong LI, Yupeng LI. Chemical Compounds Isolated from Pleione Bulbocodioides and Their Bioactive Activities[J]. Journal of Kunming Medical University, 2023, 44(5): 1-5. doi: 10.12259/j.issn.2095-610X.S20230528

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Chemical Compounds Isolated from Pleione Bulbocodioides and Their Bioactive Activities

doi: 10.12259/j.issn.2095-610X.S20230528

1.
School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products，Kunming Medical University，Kunming Yunnan 650500
2.
Pharmacy Department，The People's Hospital of Lincang，Lincang Yunnan 677000
3.
Women’s Federation of Kunming Medical University ，Kunming Yunnan 650500，China

Received Date: 2023-01-09
Available Online: 2023-05-11
Publish Date: 2023-05-25

Abstract

Abstract

Objective To study the chemical constituents from the herbs of Pleione bulbocodioides and find theirs antitumor bioactive compounds. Methods The constituents were extracted by ethyl acetate and isolated by CC and Sephadex LH-20. Their structures were identified by spectroscopic analysis （¹H NMR, ¹³CNMR and EIMS）. The antitumor activity of the constituents was studied by MTT assay in vitro. Results Twelve compouds were obtained and identified as 4-methoxy-2, 7-dihydroxyphenan- -threne （1）, （8R）-4, 5′-dihydroxy-8-hydroxymehtyl-3′-methoxydeoxybenzoin （2）, 4, 7-dihydroxy-2-methoxy-9, 10-dihydrophenanthrene （3） 2-hydroxy-4, 7-dimethoxy-phenanthrene （4） Ursolic acid （5） β-sitosterol （6） 2-hydroxy-4, 7-dimethoxy-9, 10-dihydrophenanthrene （7） 4- （Benzofuranyl）-phenol （8） Flavanthrinin （9） Coelonin （10） CH₃ （CH₂）₂₇OH （11） and 4-dimethoxy benzaldehyde （12）. The results of anti-tumor activity test of compounds 1～5 showed that 2 expressed good inhibitory activity on SKOV-3 cell line. Conclusion Compounds 2, 5, 8, 11 have been isolated from the herbs for the first time and IC₅₀ of 2 on SKOV-3 cell line is 12.79 μM.
- Pleione bulbocodioides,
- Chemical constituents,
- Bioactive activity

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