Expression Characteristics of COX2 and CDX2 in Laryngeal Squamous Cell Carcinoma and Their Prognostic Values in Patients with Laryngeal Squamous Cell Carcinoma

Liping ZHUANG; Kaixin WANG; Fang WANG; Hong YE

doi:10.12259/j.issn.2095-610X.S20230529

Volume 44 Issue 5

May 2023

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Liping ZHUANG, Kaixin WANG, Fang WANG, Hong YE. Expression Characteristics of COX2 and CDX2 in Laryngeal Squamous Cell Carcinoma and Their Prognostic Values in Patients with Laryngeal Squamous Cell Carcinoma[J]. Journal of Kunming Medical University, 2023, 44(5): 47-52. doi: 10.12259/j.issn.2095-610X.S20230529

Citation:

Liping ZHUANG, Kaixin WANG, Fang WANG, Hong YE. Expression Characteristics of COX2 and CDX2 in Laryngeal Squamous Cell Carcinoma and Their Prognostic Values in Patients with Laryngeal Squamous Cell Carcinoma[J]. Journal of Kunming Medical University, 2023, 44(5): 47-52. doi: 10.12259/j.issn.2095-610X.S20230529

Citation:

Liping ZHUANG, Kaixin WANG, Fang WANG, Hong YE. Expression Characteristics of COX2 and CDX2 in Laryngeal Squamous Cell Carcinoma and Their Prognostic Values in Patients with Laryngeal Squamous Cell Carcinoma[J]. Journal of Kunming Medical University, 2023, 44(5): 47-52. doi: 10.12259/j.issn.2095-610X.S20230529

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Expression Characteristics of COX2 and CDX2 in Laryngeal Squamous Cell Carcinoma and Their Prognostic Values in Patients with Laryngeal Squamous Cell Carcinoma

doi: 10.12259/j.issn.2095-610X.S20230529

Liping ZHUANG^{1, 2},
Kaixin WANG³,
Fang WANG²,
Hong YE^{2
,
,}

1.
Dept. of Pathology，Dujiangyan Municipal Hospital of Traditional Chinese Medicine，Dujiangyan Sichuan 611830
2.
Dept. of Pathology and Pathophysiology，School of Basic Medicine，Kunming Medical University，Kunming Yunnan 650500
3.
Dept. of Pathology，Huazhong University of Science and Technology Union Shenzhen Hospital， Shenzhen Guangdong 518052，China

Received Date: 2023-02-23
Publish Date: 2023-05-25

Abstract

Abstract

Objective To investigate the expression characteristics of COX2 and CDX2 in the development of laryngeal squamous cell carcinoma and their relationship with the prognosis in patients with laryngeal squamous cell carcinoma. Methods The expression characteristics of COX2 and CDX2 in laryngeal polyps, laryngeal papilloma and laryngeal squamous cell carcinoma were detected at their protein levels by immunohistochemistry （IHC） and image analysis （IA） techniques in laryngeal squamous cell carcinoma. Twenty-five cases with laryngeal squamous cell carcinoma were followed up to understand the patient prognostic effects of COX2 and CDX2. Results 1. The expression of COX2 in laryngeal squamous cell carcinoma was lower than that of laryngeal polyps （P = 0.004） and laryngeal papilloma （P = 0.001）. The expression of COX2 in T3-T4 stage laryngeal squamous cell carcinoma was higher than that in T1-T2 stage, and the difference was statistically significant （P = 0.001）. The expression of COX2 in laryngeal squamous cell carcinoma with lymph node metastasis was higher than that in laryngeal squamous cell carcinoma without lymph node metastasis, the expression of COX2 increased gradually in low, medium and high differentiated laryngeal squamous cell carcinoma, but the differences were not statistically significant （P > 0.05）. 2. The expressions of CDX2 protein was weakly positive in laryngeal polyp and laryngeal papilloma, and the expressions of CDX2 protein was negative in laryngeal squamous cell carcinoma, and the difference was not statistically significant （ P > 0.05）. 3. Positive or negative expression of COX2 protein had no effect on the prognosis of patients. Conclusion 1. Low expression of COX2 may be associated with the development of laryngeal squamous cell carcinoma, but cannot predict the prognosis in patients with laryngeal squamous cell carcinoma. 2. CDX2 may not be a risk factor for laryngeal squamous cell carcinoma.
- COX2 protein,
- CDX2 protein,
- Laryngeal squamous cell carcinoma,
- Immunohistochemistry,
- Image analysis with computer

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References(29)

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