Correlation between Plasma proBDNF Level and Primary Sjögren’s Syndrome with Depressive Symptoms

Daying FENG; Huaying CHEN; Hongying PAN; Zhilan YANG; Shan YAN; Li ZHOU

doi:10.12259/j.issn.2095-610X.S20230605

Volume 44 Issue 6

Jun. 2023

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Daying FENG, Huaying CHEN, Hongying PAN, Zhilan YANG, Shan YAN, Li ZHOU. Correlation between Plasma proBDNF Level and Primary Sjögren’s Syndrome with Depressive Symptoms[J]. Journal of Kunming Medical University, 2023, 44(6): 54-58. doi: 10.12259/j.issn.2095-610X.S20230605

Citation:

Daying FENG, Huaying CHEN, Hongying PAN, Zhilan YANG, Shan YAN, Li ZHOU. Correlation between Plasma proBDNF Level and Primary Sjögren’s Syndrome with Depressive Symptoms[J]. Journal of Kunming Medical University, 2023, 44(6): 54-58. doi: 10.12259/j.issn.2095-610X.S20230605

Citation:

Daying FENG, Huaying CHEN, Hongying PAN, Zhilan YANG, Shan YAN, Li ZHOU. Correlation between Plasma proBDNF Level and Primary Sjögren’s Syndrome with Depressive Symptoms[J]. Journal of Kunming Medical University, 2023, 44(6): 54-58. doi: 10.12259/j.issn.2095-610X.S20230605

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Correlation between Plasma proBDNF Level and Primary Sjögren’s Syndrome with Depressive Symptoms

doi: 10.12259/j.issn.2095-610X.S20230605

1.
Dept. of Rheumatology and Immunology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
The Mental Health Center Affiliated to Kunming Medical University，Kunming Yunnan 650224
3.
Institute of Biomedical Engineering，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2023-04-14
Available Online: 2023-06-16
Publish Date: 2023-06-25

Abstract

Abstract

Objective To study the role of plasma proBDNF level in patients with primary Sjogren's syndrome （pSS） with depressive symptoms, and to explore related factors, so as to provide evidence for early intervention. Methods A total of 42 pSS patients and 81 healthy controls were investigated with self-made general information questionnaire and PHQ-9 scale, and 42 pSS patients were investigated and scored with Coping style questionnaire （SCSQ） and social support rating scale （SSRS）. European Antirheumatic Association pSS Disease Activity Scale （ESSDAI） was used to evaluate the disease activity of pSS. After informed consent was obtained, 3-5 ml peripheral blood was collected to detect the level of proBDNF. Results The increase of plasma proBDNF level in patients with pSS complicated with depressive symptoms was the most significant （P < 0.05）, and less social support was a risk factor. Conclusion ProBDNF may be involved in the pathogenesis of pSS with depressive symptoms, and these patients need more social support.
- Primary Sjögren’s syndrome,
- Precursor of brain derived neurotropin,
- Psychosocial factors

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References(20)

References

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