Effects of Estrogen Application Duration in HRT-FET on Pregnancy Outcomes

Zhengmei PAN; Yanzhi WU; Yan Li; Yiyue ZHAO; Xi HU; Yang LIU

doi:10.12259/j.issn.2095-610X.S20230804

Volume 44 Issue 8

Aug. 2023

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Zhengmei PAN, Yanzhi WU, Yan Li, Yiyue ZHAO, Xi HU, Yang LIU. Effects of Estrogen Application Duration in HRT-FET on Pregnancy Outcomes[J]. Journal of Kunming Medical University, 2023, 44(8): 85-90. doi: 10.12259/j.issn.2095-610X.S20230804

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Zhengmei PAN, Yanzhi WU, Yan Li, Yiyue ZHAO, Xi HU, Yang LIU. Effects of Estrogen Application Duration in HRT-FET on Pregnancy Outcomes[J]. Journal of Kunming Medical University, 2023, 44(8): 85-90. doi: 10.12259/j.issn.2095-610X.S20230804

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Effects of Estrogen Application Duration in HRT-FET on Pregnancy Outcomes

doi: 10.12259/j.issn.2095-610X.S20230804

Dept. of Reproductive Medicine，The Second Affiliated Hospital，Kunming Medical University，Kunming Yunnan 650101 ，China

Received Date: 2023-04-11
Available Online: 2023-09-01
Publish Date: 2023-08-30

Abstract

Abstract

Objective To investigate the effect of estrogen application duration on pregnancy outcomes in women of childbearing age during hormone replacement therapy frozen-thawed embryo transfer （HRT-FET）. Methods A case-control study was conducted to retrospectively analyze the clinical data of 1, 348 patients who underwent HRT-FET at the Reproductive Medicine Department of the Second Affiliated Hospital of Kunming Medical University from January 2017 to December 2020. The patients were divided into four groups based on the number of days of estrogen application before endometrial transformation: Group A （≤12 days）, Group B （13-16 days）, Group C （17-20 days）, and Group D （> 20 days）. The general clinical characteristics and pregnancy outcomes of the four groups of patients were compared. Statistical analysis included one-way analysis of variance for continuous variables and chi-square test for categorical variables. Results The endometrial thickness and estradiol （E2） levels on the day of endometrial transformation were compared among four groups of patients. Group A had the highest endometrial thickness, while the other groups showed a decreasing trend. Group A had the lowest E2 level, while the other groups showed an increasing trend. The differences were statistically significant （P < 0.05）. General clinical characteristics, including infertility duration, age at oocyte retrieval, anti-Mullerian hormone （AMH） levels, body mass index （BMI）, and progesterone （P） levels on the day of endometrial transformation, showed no significant differences among the four groups （P > 0.05）. Comparison of pregnancy outcomes among the four groups of patients, including HCG positive rate, clinical pregnancy rate, ectopic pregnancy rate, early miscarriage rate, live birth rate, singleton preterm birth rate, and singleton low birth weight rate, showed no statistically significant differences （P > 0.05）. Conclusion For patients with HRT-FET cycles, extending the duration of estrogen application may improve the endometrial thickness of patients with inadequate endometrial growth. Although there are still differences in endometrial thickness compared to normal patients, similar pregnancy outcomes as normal endometrial patients can be achieved.
- Freeze-thaw embryo transfer,
- Hormone replacement cycle,
- Estrogen,
- Pregnancy outcome

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References(24)

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