Research Progress of Perilipin Family of Lipid Droplet Surface Proteins in Cancer

Qun WANG; Yuxin SUN; Haifeng WANG

doi:10.12259/j.issn.2095-610X.S20230812

Volume 44 Issue 8

Aug. 2023

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Qun WANG, Yuxin SUN, Haifeng WANG. Research Progress of Perilipin Family of Lipid Droplet Surface Proteins in Cancer[J]. Journal of Kunming Medical University, 2023, 44(8): 139-144. doi: 10.12259/j.issn.2095-610X.S20230812

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Qun WANG, Yuxin SUN, Haifeng WANG. Research Progress of Perilipin Family of Lipid Droplet Surface Proteins in Cancer[J]. Journal of Kunming Medical University, 2023, 44(8): 139-144. doi: 10.12259/j.issn.2095-610X.S20230812

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Research Progress of Perilipin Family of Lipid Droplet Surface Proteins in Cancer

doi: 10.12259/j.issn.2095-610X.S20230812

Dept. of Urology，The Second Affiliated Hospital of Kunming Medical University， Kunming Yunnan 650106，China

Received Date: 2023-06-07
Available Online: 2023-09-02
Publish Date: 2023-08-30

Abstract

Abstract

With cancer becoming increasingly prevalent and affecting younger populations, there is growing concern about its development and progression. It is worth noting that the global population of obese individuals is also on the rise, and numerous studies have found that obesity increases the risk of developing cancer. Abnormal lipid metabolism is one of the prominent metabolic changes in cancer development. Therefore, it is crucial to pay attention to the role of lipid metabolism in cancer. In recent years, as researchers have delved deeper into the study of lipid metabolism, the perilipin family of lipid droplet surface proteins has been discovered. These proteins not only serve as structural proteins for lipid droplets, but they are also closely associated with cancer cell proliferation, invasion, and metastasis. Therefore, the perilipin family may represent a potential and promising target for cancer treatment. This review primarily focuses on the latest findings regarding the roles and mechanisms of the perilipin family members in cancer. These studies will deepen our understanding of the functions of the perilipin family in the progression of cancer and provide new insights for better cancer prevention and control.
- Cancer,
- Lipid droplets,
- Perilipin family of lipid droplet surface proteins,
- Lipid metabolism

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References(41)

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