Expression of CAV1 in Tumor Tissues and Its Effect on Survival Prognosis of Patients

Yixiao LIU; Mengyuan SHOU; Ying ZHANG; Rongqiang ZHANG; Na SUN

doi:10.12259/j.issn.2095-610X.S20231107

Volume 44 Issue 11

Nov. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(11): 47-55

Yixiao LIU, Mengyuan SHOU, Ying ZHANG, Rongqiang ZHANG, Na SUN. Expression of CAV1 in Tumor Tissues and Its Effect on Survival Prognosis of Patients[J]. Journal of Kunming Medical University, 2023, 44(11): 47-55. doi: 10.12259/j.issn.2095-610X.S20231107

Citation:

Yixiao LIU, Mengyuan SHOU, Ying ZHANG, Rongqiang ZHANG, Na SUN. Expression of CAV1 in Tumor Tissues and Its Effect on Survival Prognosis of Patients[J]. Journal of Kunming Medical University, 2023, 44(11): 47-55. doi: 10.12259/j.issn.2095-610X.S20231107

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Expression of CAV1 in Tumor Tissues and Its Effect on Survival Prognosis of Patients

doi: 10.12259/j.issn.2095-610X.S20231107

Dept. of Epidemiology and Health Statistics，Shaanxi University of Chinese Medicine，Xianyang Shaanxi 712046，China

Received Date: 2022-01-01
Available Online: 2023-11-03
Publish Date: 2023-11-30

Abstract

Abstract

Objective Bioinformatics was used to analyze the correlation between CAV1 expression and its prognostic value and immune infiltration in various tumors and to clarify its value in evaluating tumor prognosis. Methods The mRNA expression level of CAV1 gene was analyzed based on TCGA and GTEx databases, the protein expression level of CAV1 gene was analyzed by CPTAC database, the correlation between CAV1 expression and survival and prognosis of tumor patients was analyzed by univariate COX regression, and the tumor immunohistochemistry level of CAV1 expression was analyzed by HPA database. Spearman correlation analysis of tumor and immune infiltrating cells. Results The mRNA expression of the CAV1 gene was different in 26 tumor tissues（P < 0.05）, and the high expression of CAV1 had adverse effects on the overall survival of bladder urothelial carcinoma, low-grade glial carcinoma of the brain and head and neck squamous cell carcinoma. It is closely related to various tumor immune infiltrating cells in BLCA, LGG, and HNSC. Univariate COX regression analysis showed that CAV1（HR = 1.489, P = 0.0078） and age（HR = 1.424, P = 0.0022） were risk factors for overall survival in BLCA patients, while CAV1（HR = 2.432, P = 0.0006） and WHO grade（HR = 3.023, P = 0.0004） were risk factors for overall survival in LGG patients.CAV1（HR = 1.432, P = 0.0085） and clinicopathological classification（HR = 1.806, P = 0.0006） were risk factors for overall survival in HNSC patients. Conclusion The expression and regulation of CAV1 gene are correlated with the occurrence and development of BLCA, LGG and HNSC, patient prognosis and tumor immunity. They may be a prognostic factor of BLCA, LGG and HNSC patients.
- CAV1,
- Human tumor,
- Survival Prognosis,
- Immunity

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