Influence of Intrauterine Hyperglycemia Environment on Peripheral Inflammatory Response in Offspring of Gestational Diabetes Mellitus

Yaling ZHAO; Kun WU; Kai WANG; Rong HUANG; Genya HE; Yuhui NA; Miao HE; Zhenbo DING; Caiying ZHANG

doi:10.12259/j.issn.2095-610X.S20231110

Volume 44 Issue 11

Nov. 2023

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Yaling ZHAO, Kun WU, Kai WANG, Rong HUANG, Genya HE, Yuhui NA, Miao HE, Zhenbo DING, Caiying ZHANG. Influence of Intrauterine Hyperglycemia Environment on Peripheral Inflammatory Response in Offspring of Gestational Diabetes Mellitus[J]. Journal of Kunming Medical University, 2023, 44(11): 70-75. doi: 10.12259/j.issn.2095-610X.S20231110

Citation:

Yaling ZHAO, Kun WU, Kai WANG, Rong HUANG, Genya HE, Yuhui NA, Miao HE, Zhenbo DING, Caiying ZHANG. Influence of Intrauterine Hyperglycemia Environment on Peripheral Inflammatory Response in Offspring of Gestational Diabetes Mellitus[J]. Journal of Kunming Medical University, 2023, 44(11): 70-75. doi: 10.12259/j.issn.2095-610X.S20231110

Citation:

Yaling ZHAO, Kun WU, Kai WANG, Rong HUANG, Genya HE, Yuhui NA, Miao HE, Zhenbo DING, Caiying ZHANG. Influence of Intrauterine Hyperglycemia Environment on Peripheral Inflammatory Response in Offspring of Gestational Diabetes Mellitus[J]. Journal of Kunming Medical University, 2023, 44(11): 70-75. doi: 10.12259/j.issn.2095-610X.S20231110

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Influence of Intrauterine Hyperglycemia Environment on Peripheral Inflammatory Response in Offspring of Gestational Diabetes Mellitus

doi: 10.12259/j.issn.2095-610X.S20231110

1.
Dept. of Pediatrics
2.
Dept. of Medical Laboratory
3.
Dept. of Obstetrics，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2023-09-13
Available Online: 2023-11-10
Publish Date: 2023-11-30

Abstract

Abstract

Objective To explore the effect of intrauterine hyperglycemia on peripheral inflammatory reaction of cord blood of offspring with gestational diabetes mellitus（GDM）. Methods The objects of this study were the offspring of women who delivered in the first affiliated hospital of Kunming Medical University from November 2019 to May 2023．The GDM group included 108 infants（67 male cases and 41 female cases） of mothers with GDM．The control group included 150 infants（82 male cases and 68 female cases） of women with normal glucose tolerance.The concentrations of umbilical vein blood serum IL-1β, IL-2, IL-4, IL-5, IL-6, L-8, IL-10, IL-17, TNF-α, IFN-α, IFN-γ and IL-12_P70 were measured by flow cytometry CBA technology. Results The levels of vein cord blood serum pro-inflammatory factors IL-6, IL-8 and TNF-α were higher than the control group, the differences was statistical （6.65±0.51 vs 4.02±0.40, P = 0.007; 13.96±1.10 vs 7.36±0.50, P = 0.040; 1.27±0.10 vs 0.56±0.01, P = 0.020）. The level of IFN-γ was lower than the control group（5.67±0.50 vs 10.54±0.90, P = 0.038）, the differences were statistical. There was no differences in the levels of IL-1β, IL-2, IL-4, IL-5, IL-10, IL-12_P70, IL-17, IFN-α. Conclusion Even in GDM offspring with good blood sugar control during pregnancy, the innate immune system is overactivated, and pro-inflammatory factors IL-6, IL-8, and TNF-α are released excessively, laying a clinical foundation for further understanding whether the activation of the peripheral innate immune system in the GDM intrauterine hyperglycemic environment can induce the occurrence of neuroinflammation in the brain and its contribution in neuroinflammation.
- Cord blood,
- Gestational diabetes mellitus,
- Offspring,
- Inflammatorresponse,
- Cytokine

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References(18)

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