Effects of Different Vitamin D Doses on Bone Metabolism and Growth and Development Indicators of Preterm infants：A Cohort Study

Yongyi ZOU; Zhiye QI; Dongmei SUN; Chunmei Wan; Kun LIANG

doi:10.12259/j.issn.2095-610X.S20231111

Volume 44 Issue 11

Nov. 2023

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Yongyi ZOU, Zhiye QI, Dongmei SUN, Chunmei Wan, Kun LIANG. Effects of Different Vitamin D Doses on Bone Metabolism and Growth and Development Indicators of Preterm infants：A Cohort Study[J]. Journal of Kunming Medical University, 2023, 44(11): 76-81. doi: 10.12259/j.issn.2095-610X.S20231111

Citation:

Yongyi ZOU, Zhiye QI, Dongmei SUN, Chunmei Wan, Kun LIANG. Effects of Different Vitamin D Doses on Bone Metabolism and Growth and Development Indicators of Preterm infants：A Cohort Study[J]. Journal of Kunming Medical University, 2023, 44(11): 76-81. doi: 10.12259/j.issn.2095-610X.S20231111

Citation:

Yongyi ZOU, Zhiye QI, Dongmei SUN, Chunmei Wan, Kun LIANG. Effects of Different Vitamin D Doses on Bone Metabolism and Growth and Development Indicators of Preterm infants：A Cohort Study[J]. Journal of Kunming Medical University, 2023, 44(11): 76-81. doi: 10.12259/j.issn.2095-610X.S20231111

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Effects of Different Vitamin D Doses on Bone Metabolism and Growth and Development Indicators of Preterm infants：A Cohort Study

doi: 10.12259/j.issn.2095-610X.S20231111

1.
Dept. of Pediatrics，The1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Dept. of Pediatrics，The Southern Central Hospital of Yunnan Province，Honghe Yunnan 661018，China

Received Date: 2022-09-04
Available Online: 2023-11-10
Publish Date: 2023-11-30

Abstract

Abstract

Objective To analyze the effects of various dosages of vitamin D（VitD） supplementation on bone metabolism and growth and development indicators of preterm infants. Methods Preterm infants with gestational age < 34 weeks or birth weight < 1500 g were divided into high-dose group（Total vitamin D intake ≥900 IU） and low-dose group（Total vitamin D intake < 900 IU） based on the VitD intake. Multiple linear regression approach for the analysis of the relationships between VitD intake and growth and development indicators（including the growth rate of weight, length, and head circumference） and bone metabolism indicators（including serum 25-hydroxyvitamin D, Alkaline phosphatase, calcium, and phosphorus levels） of preterm infants at 28 days after birth or discharge. Results A total of 229 preterm infants met inclusion criteria, including 135 cases in the high-dose group and 94 cases in the low-dose group. There were no significant differences in serum 25-hydroxyvitamin D and calcium levels among the groups（P > 0.05）. Preterm infants in high-dose group had a lower incidence of hypophosphatemia（χ² = 6.215, P = 0.045） and a higher level of serum alkaline phosphatase（Z = 3.174, P = 0.002） compared to the low-dose group. There were no significant differences in the growth rate of weight and length among the groups（P > 0.05）. Preterm infants with high-dose group had a higher percentage of the growth rate of head circumference ≥5 mm per week（χ² = 4.036, P < 0.001） and a higher growth rate of head circumference（β = 1.510, 95%CI: 0.751～2.269, P < 0.001） compared to the low-dose group. Conclusion High-dose vitamin D intake can stabilize bone metabolism and promote the growth rate of head circumference in preterm infants.
- Preterm infant,
- Vitamin D,
- Bone metabolism,
- Growth and development

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