Correlation between <i>PEAR1</i> Gene Polymorphisms and Ischemic Stroke

Yunfang ZHANG; Shanshan ZHUANG; Yan YU; Zheng LI; Xiaoming WU; Xiaogai NIE

doi:10.12259/j.issn.2095-610X.S20231120

Volume 44 Issue 11

Nov. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(11): 135-139

Yunfang ZHANG, Shanshan ZHUANG, Yan YU, Zheng LI, Xiaoming WU, Xiaogai NIE. Correlation between PEAR1 Gene Polymorphisms and Ischemic Stroke[J]. Journal of Kunming Medical University, 2023, 44(11): 135-139. doi: 10.12259/j.issn.2095-610X.S20231120

Citation:

Yunfang ZHANG, Shanshan ZHUANG, Yan YU, Zheng LI, Xiaoming WU, Xiaogai NIE. Correlation between PEAR1 Gene Polymorphisms and Ischemic Stroke[J]. Journal of Kunming Medical University, 2023, 44(11): 135-139. doi: 10.12259/j.issn.2095-610X.S20231120

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Correlation between PEAR1 Gene Polymorphisms and Ischemic Stroke

doi: 10.12259/j.issn.2095-610X.S20231120

Dept. of Medical Laboratory，Yan'an Hospital Affiliated to Kunming Medical University，Kunming Yunnan 650051，China

Received Date: 2023-08-27
Available Online: 2023-11-11
Publish Date: 2023-11-30

Abstract

Abstract

Objective To analyze the correlation between PEAR1 gene polymorphism and ischemic stroke, so as to provide a scientific basis for further research on the pathogenesis of ischemic stroke, and provide new ideas for disease prevention and treatment Methods A total of 150 patients with acute ischemic stroke in the Department of Neurology, Yan’ an hospital affiliated to the Kunming Medical University were selected as the experimental group and 150 healthy persons as the control group, a polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） was used to analyze the Single-nucleotide polymorphism at rs12041331 in PEAR1 gene. The genotypes were verified by sequencing. Results Chi-square test results showed that between the ischemic stroke group and control group, the distribution of GG, GAandAA genotypes and allele frequency of G, A on PEAR1 gene rs12041331G > A polymorphism site had significant differences（p < 0.05）. The proportion of diabetes mellitus and hypertension and the level of homocysteine homocysteine（HCY） in the ischemic stroke group were significantly higher than those in the control group（p < 0.05）.Logistic regression analysis showed that mutations at the PEAR1 gene rs12041331G > A site might be a risk factor for ischemic stroke. Conclusion The polymorphism of PEAR1 gene rs12041331G > A site is associated with ischemic stroke Genetic predisposition. The PEAR1 gene rs12041331G > A site may be a candidate gene for ischemic stroke risk prediction.
- Ischemic stroke,
- Single-nucleotide polymorphism,
- Polymerase chain reaction-restriction fragment length polymorphism

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References(15)

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