Efficacy and Safety of Bevacizumab Combined with Temozolomide for Recurrent High-Grade Glioma

Dongyan YANG; Hua LIN; Yuxiao ZHANG; Kunying ZHAO; Lirong XIANG; Shuda YANG; Weiyan HU

doi:10.12259/j.issn.2095-610X.S20240410

Volume 45 Issue 4

Apr. 2024

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Dongyan YANG, Hua LIN, Yuxiao ZHANG, Kunying ZHAO, Lirong XIANG, Shuda YANG, Weiyan HU. Efficacy and Safety of Bevacizumab Combined with Temozolomide for Recurrent High-Grade Glioma[J]. Journal of Kunming Medical University, 2024, 45(4): 67-73. doi: 10.12259/j.issn.2095-610X.S20240410

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Efficacy and Safety of Bevacizumab Combined with Temozolomide for Recurrent High-Grade Glioma

doi: 10.12259/j.issn.2095-610X.S20240410

1.
School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products，Kunming Yunnan 650500
2.
Dept. of Pharmacy，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650100
3.
Biomedical Engineering Research Institute of Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2023-12-26
Available Online: 2024-04-28
Publish Date: 2024-04-29

Abstract

Abstract

Objective To explore the short-term efficacy, safety, and prognostic factors affecting the overall survival （OS） of patients with recurrent high-grade glioma （HGG） treated with bevacizumab （BEV） alone and bevacizumab in combination with temozolomide （TMZ）. Methods According to the response assessment in neurooncology （RANO） criteria for the treatment of gliomas, objective response rate （ORR） and disease control rate （DCR） were used as indicators to retrospectively analyze the clinical medical records of 31 patients with recurrent HGG at Yunnan Cancer Hospital from August 2020 to July 2023. The patients were divided into a control group （BEV） and a treatment group （BEV+TMZ）, and the recent efficacy of the two groups was evaluated. Cox univariate and multivariate analysis methods were used to analyze the impact of group （control group vs. treatment group）, gender, age, disease grading, admission score, histopathological classification, etc., on the overall survival （OS） of 31 patients with recurrent HGG. Adverse reactions （ADR） between the two groups were compared using a chi-square test to evaluate the safety. Results The ORR of the treatment group was 63.16%, and the ORR of the control group was 16.67%. The difference was statistically significant （χ² = 6.419, P = 0.011）. The DCR of the treatment group was 89.47%, and the DCR of the control group was 75.00%. There was no significant difference in DCR （χ² = 0.320, P = 0.571）. The median survival time （mOS） in the control group was 7 months （95%CI: 3.605～10.395）, and the median survival time （mOS） in the treatment group was 14 months （95%CI: 3.853～24.147）. There was no significant difference in mOS between the two groups （χ² = 0.829, P = 0.363）. There were significant differences in Cox univariate analysis admission score and histopathological classification among 31 patients with recurrent HGG （P < 0.05）, and statistically significant differences in histopathological classification by multivariate analysis （P < 0.05）. There was no significant difference in nausea, vomiting, fatigue and diarrhea between the two groups after treatment （P > 0.05）. There were statistically significant differences in the reduction rates of platelets and white blood cells （P < 0.05）, after symptomatic treatment, both groups of ADRs were alleviated. Conclusion The short-term curative effect of the treatment group was better than that of the control group in the treatment of recurrent HGG, the ADRs after recurrent HGG treatment in 2 groups were tolerable and safe, and the histopathological classification may be a prognostic factor affecting the OS of 31 patients with recurrent HGG.
- High-grade glioma,
- Bevacizumab,
- Temozolomide

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References

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