Analysis of the Clinicopathological and Molecular Features of Appendiceal Mucinous Neoplasms

Xuedan WANG; Yifan LIU; Zihan YANG; Dandan ZHANG; Yi DUAN; Zhihui YANG

doi:10.12259/j.issn.2095-610X.S20240706

Volume 45 Issue 7

Jul. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(7): 42-48

Xuedan WANG, Yifan LIU, Zihan YANG, Dandan ZHANG, Yi DUAN, Zhihui YANG. Analysis of the Clinicopathological and Molecular Features of Appendiceal Mucinous Neoplasms[J]. Journal of Kunming Medical University, 2024, 45(7): 42-48. doi: 10.12259/j.issn.2095-610X.S20240706

Citation:

Xuedan WANG, Yifan LIU, Zihan YANG, Dandan ZHANG, Yi DUAN, Zhihui YANG. Analysis of the Clinicopathological and Molecular Features of Appendiceal Mucinous Neoplasms[J]. Journal of Kunming Medical University, 2024, 45(7): 42-48. doi: 10.12259/j.issn.2095-610X.S20240706

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Analysis of the Clinicopathological and Molecular Features of Appendiceal Mucinous Neoplasms

doi: 10.12259/j.issn.2095-610X.S20240706

Dept. of Pathology，The Affiliated Hospital of Southwest Medical University/Precision Pathology Diagnosis for Serious Dieases Key Laboratory of LuZhou，Luzhou Sichuan 646000，China

Received Date: 2024-03-13
Available Online: 2024-06-17
Publish Date: 2024-07-25

Abstract

Abstract

Objective To investigate the clinicopathological and molecular features of appendiceal mucinous neoplasms （AMNs）, compare the differences bewteen the LAMN and HAMN. Methods 32 cases of AMNs were collected between January 2015 and September 2021. They were hospitalized in the Affiliated Hospital of Southwest Medical University. 10 samples of them were selected for Next Generation Sequencing （NGS） analysis of 425 genes. Results The majority of AMNs were female （68.8%）. Most patients had positive tumor markers. The proportion of distant metastasis, recurrence and death in HAMN patients were higher than those in LAMN patients. KRAS, GNAS and BRAF gene mutations were common in AMNs patients. The SNP of MTHFR and NQO1 were common in AMNs patients. The TMB of LAMN and HAMN patients were both lower, and there was no statistical significance between them （P > 0.05）. Conclusion AMNs have special clinical pathological and molecular pathological changes, but there is no significant difference between HAMN and LAMN.
- Appendiceal mucinous neoplasms,
- Clinicopathological features,
- Molecular features,
- Next generation sequencing

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References(23)

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