Relationship between hs-CRP，CCL2，CCL3 and Neonatal Bacterial Infection and Their Predictive Value for Efficacy

Zhenxing YUAN; Wenfei SUN; Weidong WANG

doi:10.12259/j.issn.2095-610X.S20240718

Volume 45 Issue 7

Jul. 2024

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2024 > 45(7): 119-125

Zhenxing YUAN, Wenfei SUN, Weidong WANG. Relationship between hs-CRP，CCL2，CCL3 and Neonatal Bacterial Infection and Their Predictive Value for Efficacy[J]. Journal of Kunming Medical University, 2024, 45(7): 119-125. doi: 10.12259/j.issn.2095-610X.S20240718

Citation:

Zhenxing YUAN, Wenfei SUN, Weidong WANG. Relationship between hs-CRP，CCL2，CCL3 and Neonatal Bacterial Infection and Their Predictive Value for Efficacy[J]. Journal of Kunming Medical University, 2024, 45(7): 119-125. doi: 10.12259/j.issn.2095-610X.S20240718

Citation:

PDF( 667 KB)

Relationship between hs-CRP，CCL2，CCL3 and Neonatal Bacterial Infection and Their Predictive Value for Efficacy

doi: 10.12259/j.issn.2095-610X.S20240718

Dept. of Clinical Laboratory，Langfang People's Hospital，Langfang Hebei 065000，China

Received Date: 2024-02-27
Available Online: 2024-06-14
Publish Date: 2024-07-25

Abstract

Abstract

Objective To explore the application value of high-sensitivity C-reactive protein （hs-CRP）, chemokine CC motif ligand （CCL）, and CCL3 in the treatment of neonatal bacterial infections. Methods A total of 70 cases of neonatal bacterial infection admitted to the People's Hospital of Langfang City from January 2021 to January 2023 were selected as the bacterial infection group. In addition, 70 cases of neonatal viral infection and 70 cases of non-infected newborns were selected as the viral infection group and control group, respectively, at a ratio of 1∶1. The serum hs-CRP, CCL2, and CCL3 levels of the three groups and the bacterial infection group were compared at admission, the serum levels of each index were compared among the bacterial infection group with different therapeutic effects, and a receiver operating characteristic curve （ROC） was drawn to analyze the predictive efficacy of each serum index on therapeutic effects. The relative risk （RR） was used to analyze the impact of different expression of each serum index on the therapeutic effect of neonatal bacterial infection. Results The expressions of hs-CRP, CCL2 and CCL3 in the bacterial infection group and viral infection group at admission were higher than those in the control group （P < 0.05）. The expressions of hs-CRP, CCL2 and CCL3 in severe children with bacterial infection at admission were higher than those in mild children （P < 0.05）. The levels of hs-CRP, CCL2 and CCL3 in the ineffective subgroup were higher than those in the effective subgroup at admission, 24 h, 3rd day and 5th day （P < 0.05）. The combined effect of serum hs-CRP, CCL2 and CCL3 on neonatal bacterial infection at admission, 24 h, 3 d and 5 d was better than that of single index at each time point, and the combined prediction of AUC at 24 h was the largest. According to the cut-off value of each index 24 hours after admission, the risk of treatment failure in children with high expression of hs-CRP, CCL2 and CCL3 was 3.577 times, 3.357 times and 2.630 times higher than that in children with low expression. Conclusions hs-CRP, CCL2 and CCL3 are highly expressed in the serum of neonatal bacterial infection, and they are closely related to the severity of the disease and the therapeutic effect of the children. The combination of the three serum indicators has good reference value in predicting the therapeutic effect of the children.
- ROC curve,
- hs-CRP,
- Inflammatory chemokines,
- Neonatal bacterial infection,
- Therapeutic effect,
- Value

FullText(HTML)

References(25)

References

[1]	Cohen R,Romain O,Tauzin M,et al. Neonatal bacterial infections: Diagnosis,bacterial epidemiology and antibiotic treatment[J]. Infect Dis Now,2023,53(8S):104793.
[2]	Korang S K,Nava C,Mohana S P,et al. Antibiotics for hospital-acquired pneumonia in neonates and children[J]. Cochrane Database Syst Rev,2021,11(11):CD013864.
[3]	Murless-Collins S,Kawaza K,Salim N,et al. Blood culture versus antibiotic use for neonatal inpatients in 61 hospitals implementing with the NEST360 Alliance in Kenya,Malawi,Nigeria,and Tanzania: A cross-sectional study[J]. BMC Pediatr,2023,23(Suppl 2):568.
[4]	Liu Y L,Sun X H,Wang Y Q,et al. Evaluation of associated markers of neonatal pathological jaundice due to bacterial infection[J]. Iran J Public Health,2021,50(2):333-340.
[5]	Ngwengi Y,Ngaba G P,Nida M,et al. Evaluation of CRP as a marker for bacterial infection and malaria in febrile children at the douala gyneco-obstetric and pediatric hospital[J]. PLoS One,2023,18(7):e0289012. doi: 10.1371/journal.pone.0289012
[6]	白鹏,韩桂珍,鲁丽. 支气管哮喘患儿痰液中CXCR2、CCR1、CCL3、CCL2表达及与肺功能和气道炎症的关系[J]. 河北医药,2019,41(23):3555-3558. doi: 10.3969/j.issn.1002-7386.2019.23.008
[7]	邵肖梅. 实用新生儿学[M]. 第4版. 北京: 人民卫生出版社,2011: 317-322.
[8]	龚剑锋,万华,李秋红. 降阶梯疗法治疗新生儿细菌感染性肺炎的疗效及对血清PCT、WBC和CRP的影响[J]. 东南大学学报(医学版),2018,37(5):868-872. doi: 10.3969/j.issn.1671-6264.2018.05.024
[9]	Li Z,Yuan T M. Neutrophil extracellular traps in adult diseases and neonatal bacterial infectious diseases: A review[J]. Heliyon,2023,10(1):e23559.
[10]	王焕成. 全血C反应蛋白与血常规中白细胞计数联合检验在儿科感染性疾病中的诊断价值[J]. 中国实用医药,2020,15(12):105-107.
[11]	Russell N J,Stöhr W,Plakkal N,et al. Patterns of antibiotic use,pathogens,and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS)[J]. PLoS Med,2023,20(6):e1004179. doi: 10.1371/journal.pmed.1004179
[12]	Naramura T,Imamura H,Yoshimatsu H,et al. The predictive value of procalcitonin and high-sensitivity C-reactive protein for early bacterial infections in preterm neonates[J]. Neonatology,2021,118(1):28-36. doi: 10.1159/000512523
[13]	Borowski S,Shchors I,Bar-Meir M. Time from symptom onset may influence C-reactive protein utility in the diagnosis of bacterial infections in the NICU[J]. BMC Pediatr,2022,22(1):715. doi: 10.1186/s12887-022-03783-4
[14]	刘琪,常文婧,孙祖俊,等. PCT、SAA、hs-CRP、Neu%和WBC检测对感染性疾病的临床诊断价值分析[J]. 国际检验医学杂志,2020,41(15):1835-1838,1843. doi: 10.3969/j.issn.1673-4130.2020.15.010
[15]	Sabry A,Ibrahim M,Khashana A. Assessment of pentraxin 3 in a systemic inflammatory response occurring with neonatal bacterial infection[J]. J Neonatal Perinatal Med,2021,14(4):563-568. doi: 10.3233/NPM-200550
[16]	Liang J W,Wang L L,Zhou W,et al. Value of procalcitonin in neonatal infection within 24 hours after birth: A retrospective cohort study[J]. Clin Lab,2019,65(7):181212.
[17]	Du XF,Li F,Zhang C,et al. Eosinophil-derived chemokine (hCCL15/23,mCCL6) interacts with CCR1 to promote eosinophilic airway inflammation[J]. Signal Transduct Target Ther,2021,6(1):91. doi: 10.1038/s41392-021-00482-x
[18]	Xiromerisiou G,Marogianni C,Lampropoulos IC,et al. Peripheral inflammatory markers TNF-α and CCL2 revisited: Association with Parkinson's disease severity[J]. Int J Mol Sci,2022,24(1):264. doi: 10.3390/ijms24010264
[19]	de Oliveira N ó brega C G,do Nascimento W R C,Santos PDA,et al. Schistosoma mansoni infection is associated with decreased risk of respiratory allergy symptoms and low production of CCL2[J]. Trop Med Int Health,2021,26(9):1098-1109. doi: 10.1111/tmi.13639
[20]	Hartog G D,Ederveen T H A,Venkatasubramanian P B,et al. Chemokine profiling in children and adults with symptomatic and asymptomatic respiratory viral infections[J]. J Infect,2021,83(6):709-737.
[21]	Yang Y L,Li X F,Song B,et al. The role of CCL3 in the pathogenesis of rheumatoid arthritis[J]. Rheumatol Ther,2023,10(4):793-808. doi: 10.1007/s40744-023-00554-0
[22]	Antimicrobial Resistance Collaborators. Global burden of bacterial antimicrobial resistance in 2019: A systematic analysis[J]. Lancet,2022,399(10325):629-655. doi: 10.1016/S0140-6736(21)02724-0
[23]	Silvestro E,Marino R,Cusenza F,et al. Antimicrobial stewardship experience in paediatrics: first-year activity report[J]. Eur J Clin Microbiol Infect Dis,2021,40(8):1727-1735. doi: 10.1007/s10096-021-04222-5
[24]	魏志堃. 抗生素降阶梯疗法对新生儿感染性肺炎血清PCT、CRP及WBC水平的影响[J]. 天津药学,2018,30(6):30-31. doi: 10.3969/j.issn.1006-5687.2018.06.010
[25]	赖家慧,苏增玲,陈文慧. 抗生素降阶梯疗法对新生儿感染性肺炎的临床疗效分析[J]. 国处方药,2022,20(9):111-113.

Relative Articles(20)

Relative Articles

[1]	Limei HE, Xuemin FENG, Linjun LI, Ying CHEN, Zexing YANG. Changes of Sex Hormone Levels in Infertile Population with Polycystic Ovary Syndrome after the Assisted Reproductive Technology Treatment. Journal of Kunming Medical University, 2024, 45(1): 73-77. doi: 10.12259/j.issn.2095-610X.S20240106
[2]	Shulan SHI, Lijuan QIU, Liyue KUI, Min SU, Bailing ZHOU, Rongjie LI, Jianming SUN. Diagnostic Value of Interleukin-6，Interleukin-10，High-sensitivity C-reactive Protein and Procalcitonin in Children with Acute Lymphoblastic Leukemia Complicated by Infection. Journal of Kunming Medical University, 2023, 44(1): 104-108. doi: 10.12259/j.issn.2095-610X.S20230115
[3]	Xiaofeng ZHU, Guangping ZHOU, Laicang WANG, Houjun ZHOU, Xin GENG, Hualin YU, Jinghui LI, Peng BAI. Clinical Effect of Reoperation for Recurrent Glioma. Journal of Kunming Medical University, 2022, 43(9): 77-83. doi: 10.12259/j.issn.2095-610X.S20220920
[4]	Yiming TANG, Yu CHEN, Yiming LU, Xuemei ZHANG, Jiangli YIN. Efficacy of Targeted Nursing Mode in Patients with High Altitude Pulmonary Edema. Journal of Kunming Medical University, 2022, 43(4): 158-162. doi: 10.12259/j.issn.2095-610X.S20220427
[5]	Jin-hong LI, Hong WANG. Efficacy and Safety of Valsartan Amlodipine Tablets Combined with Alpha-lipoic Acid in the Treatment of Elderly Patients with Type 2 Diabetic Nephropathy Complicated with Hypertension. Journal of Kunming Medical University, 2021, 42(4): 53-56. doi: 10.12259/j.issn.2095-610X.S20210410
[6]	Lin-kun TA, Yan-ling HUANG, Yong-ping LU. The Value of Echocardiography in Diagnosing Fetal Tetralogy of Fallot. Journal of Kunming Medical University, 2021, 42(1): 142-146. doi: 10.12259/j.issn.2095-610X.S20210126
[7]	Xiao Yan , Mi Hong Ying , Hu Jian Ying , Liu Yu . . Journal of Kunming Medical University, 2020, 41(01): 73-79.
[8]	Rong WAN, Ming-wu LI, Meng MA, Ming-hong LAI, Guang-mei Li. Efficacy of T-SPOT.TB in Treatment of Active Tuberculosis. Journal of Kunming Medical University, 2020, 41(12): 133-137. doi: 10.12259/j.issn.2095-610X.S20201237
[9]	He Ling , Xiao Jing , Yang Bi Yan , Wang Song . . Journal of Kunming Medical University, 2019, 40(07): 84-87.
[10]	Wang Rong Hua , Gu Ying , Fang Xia Ling . The Influence of Family Nursing Intervention on Treatment Effect and Quality of Life among Asthmatic Children. Journal of Kunming Medical University, 2018, 39(06): 144-148.
[11]	Wang Xu , Guo Qing Hua , Zhu Xiao Pu , Zhu Xiao Yan , Yang Ming . Effect of Endoscopic Sinus Surgery on Paranasal Sinus Fungus Balls. Journal of Kunming Medical University, 2016, 37(12): 47-50.
[12]	Qiu Mei . Unnecessity of Integrating Metabolic Indices into the Diagnosis of Polycystic Ovary Syndrome. Journal of Kunming Medical University,
[13]	Xiao Yi . The Clinical Effect of CDSP Treatment for Coronary Heart Disease. Journal of Kunming Medical University,
[14]	Feng Dan . . Journal of Kunming Medical University,
[15]	Zhang Wen Yan . . Journal of Kunming Medical University,
[16]	Tang Shi Cong . . Journal of Kunming Medical University,
[17]	Zhu Min . . Journal of Kunming Medical University,
[18]	Du Xing Hua . . Journal of Kunming Medical University,
[19]	. Application Value of Intraoperative Ultrasonography in Hepatobiliary Pancreatic Surgery. Journal of Kunming Medical University,
[20]	Dong Xin Xin . . Journal of Kunming Medical University,