Research Progress of siRNA Targeting Against HSV-1

Lei ZHOU; Wenwen LYU; Yongzhong DUAN; Wen QIAN; Jishuai CHENG

doi:10.12259/j.issn.2095-610X.S20240901

Volume 45 Issue 9

Sep. 2024

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Lei ZHOU, Wenwen LYU, Yongzhong DUAN, Wen QIAN, Jishuai CHENG. Research Progress of siRNA Targeting Against HSV-1[J]. Journal of Kunming Medical University, 2024, 45(9): 1-8. doi: 10.12259/j.issn.2095-610X.S20240901

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Lei ZHOU, Wenwen LYU, Yongzhong DUAN, Wen QIAN, Jishuai CHENG. Research Progress of siRNA Targeting Against HSV-1[J]. Journal of Kunming Medical University, 2024, 45(9): 1-8. doi: 10.12259/j.issn.2095-610X.S20240901

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Research Progress of siRNA Targeting Against HSV-1

doi: 10.12259/j.issn.2095-610X.S20240901

1.
）School of Pharmacy
2.
Institute of Biomedical Engineering，Kunming Medical University，Kunming Yunnan，650500
3.
Walvax Biotechological Limited Company，Kunming Yunnan 650101
4.
Dept. of Experimental Animals，Kunming Medical University，Kunming Yunnan 650500，China

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Corresponding author: 钱雯，北京协和医学院免疫学博士，研究员。就职于云南沃森生物技术股份有限公司，先后从事疫苗的研发、生产和质量控制及管理工作20余年。主要研究方向为疫苗技术开发及质量控制。作为主研人员完成了b型流感嗜血杆菌结合疫苗、流脑等疫苗品种的关键技术的突破、产业化研究和现场质量体系的建立。涉及品种已上市销售，先后获得云南省科技进步二等奖3项，三等奖1项。昆明市科技进步二等奖1项，三等奖1项。承担国家认定企业技术中心、云南省疫苗工程技术研究中心、云南省生物技术药物工程研究中心等多项资质平台创新能力建设工作。为生物结合疫苗研发省创新团队核心成员。昆明市创新团队带头人，入选云南省产业技术领军人才、云南省科技创新人才、昆明市有突出贡献优秀专业技术人员、获得PMI-PMP、ACP项目管理专业人士认证、MATRIZ L3国际创新认证。国家三级创新工程师及一级创新培训师。申请发明专利7项，授权5项，其中第一发明人3项。第一作者或通讯作者发表中文核心期刊文章11篇，SCI文章1篇。
Received Date: 2024-05-28
Available Online: 2024-08-29
Publish Date: 2024-09-25

Abstract

Abstract

HSV-1 is an important pathogen that can be carried and transmitted in various populations and can cause diseases including herpes labialis, capsulatus, keratitis and viral encephalitis. Although there are several types of HSV-1 vaccines in various stages of development, there is still no commercially available vaccine on the market. The specific anti-HSV-1 drugs used in clinical practice, such as acyclovir, valaciclovir and peniclovir, are also facing the serious threat of resistance. The development of new specific anti-HSV-1 drugs is one of the main tasks currently faced. siRNA is a double-stranded RNA with a length of 20-25 nucleotides that plays an interfering role by silencing gene expression at the post-transcriptional level. As a new and potential antiviral drug, siRNA has attracted much attention and developed rapidly. In this paper, we review the recent progress of siRNA in anti-HSV-1 research, including the design, delivery and targeting strategies of siRNA targeting key HSV-1 genes and HSV-1 interacting host cell genes.
- siRNA,
- HSV-1,
- Research Progress

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References(59)

References

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