The Effect of <styled-content style-type="number">1800</styled-content> MHz Electromagnetic Radiation on Learning and Cognitive Functions in 3xTg-AD Mice

Xiaoshuang XU; Guoyu MA; Runhua HE; Yongli ZHAO; Huixin WU; Yunzhen MU

doi:10.12259/j.issn.2095-610X.S20250206

Volume 46 Issue 2

Feb. 2025

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Xiaoshuang XU, Guoyu MA, Runhua HE, Yongli ZHAO, Huixin WU, Yunzhen MU. The Effect of 1800 MHz Electromagnetic Radiation on Learning and Cognitive Functions in 3xTg-AD Mice[J]. Journal of Kunming Medical University, 2025, 46(2): 37-43. doi: 10.12259/j.issn.2095-610X.S20250206

Citation:

Xiaoshuang XU, Guoyu MA, Runhua HE, Yongli ZHAO, Huixin WU, Yunzhen MU. The Effect of 1800 MHz Electromagnetic Radiation on Learning and Cognitive Functions in 3xTg-AD Mice[J]. Journal of Kunming Medical University, 2025, 46(2): 37-43. doi: 10.12259/j.issn.2095-610X.S20250206

Citation:

Xiaoshuang XU, Guoyu MA, Runhua HE, Yongli ZHAO, Huixin WU, Yunzhen MU. The Effect of 1800 MHz Electromagnetic Radiation on Learning and Cognitive Functions in 3xTg-AD Mice[J]. Journal of Kunming Medical University, 2025, 46(2): 37-43. doi: 10.12259/j.issn.2095-610X.S20250206

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The Effect of 1800 MHz Electromagnetic Radiation on Learning and Cognitive Functions in 3xTg-AD Mice

doi: 10.12259/j.issn.2095-610X.S20250206

1.
School of Public Health，Kunming Medical University，Kumming Yunnan 650500
2.
Department of Cancer Prevention and Control，Yunnan Cancer Hospital，The Third Affiliated Hospital of Kunming Medical University，Peking University Cancer Hospital Yunnan，Kunming Yunnan 650118
3.
Comprehensive Management Department of Yunnan Coalfield Geological Bureau，Kunming Yunnan 650034
4.
Public Health Department，Lijiang Center for Disease Control and Prevention，Lijiang Yunnan 674100，China

Received Date: 2024-08-26
Available Online: 2025-01-06
Publish Date: 2025-02-18

Abstract

Abstract

Objective To explore the effects of 1800 MHz electromagnetic radiation （EMR） on cognitive function of 3xTg-AD and 57C mice, providing a theoretical basis for the potential impacts of electromagnetic radiation on the human body. Methods A total of 12 3xTg-AD transgenic mice and 12 wild-type C57 mice were selected as research subjects. The one-month-old mice were divided into four groups: RF WT, Control WT, RF AD, and Control AD, with 6 mice in each group.The 1800 MHz EMR exposure experiments were conducted from 20:00 to 8:00 the next day for a duration of 5 months. After the exposure, a water maze test was conducted to evaluate the effects of EMR on spatial learning and memory abilities of 3xTg AD mice, along with measurements of body weight, brain weight, and calculation of the brain-to-body ratio. Finally, Western Blot technique was used to measure the levels of APP, NR1, and NR2A in hippocampal tissue to analyze effects of 1800 MHz EMR on the cognitive function of 3xTg AD mice. Results Under 1800 MHz EMR exposure, there were no statistically significant differences in Morris water maze spatial learning ability among the four groups （P > 0.05）. However, longer escape time, greater swimming distances, and more crossings of target quadrant were exhibited in the RF AD group compared to the other groups （P < 0.05）. Western Blot results showed that the APP protein levels in 3xTg AD mice was higher than those in C57 mice （P < 0.05）. The expression levels of NR1 protein in the WT group was higher than those in the AD group （P < 0.05）; in the AD group, the RF AD group had higher levels than the Control WT group （P < 0.05）, and the NR2A protein levels in the Control WT group were higher than in the other groups （P < 0.05）. Conclusion Prolonged exposure to 1800 MHz EMR can affect the learning and cognitive function of both 3xTg AD and C57 mice.
- Electromagnetic radiation,
- 3xTg-AD mice,
- Amyloid precursor protein,
- N-methyl-D-aspartate receptor 1,
- N-methyl-D-aspartate receptor 2A

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References(17)

References

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