The Predictive Value of Changes in Serum Uric Acid and Homocysteine Levels in Patients with Stable Coronary Artery Disease

Yuyun YOU; Jinsong YIN; Yunfei HONG; Xia ZHENG; Feifei LIU

doi:10.12259/j.issn.2095-610X.S20250214

Volume 46 Issue 2

Feb. 2025

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Yuyun YOU, Jinsong YIN, Yunfei HONG, Xia ZHENG, Feifei LIU. The Predictive Value of Changes in Serum Uric Acid and Homocysteine Levels in Patients with Stable Coronary Artery Disease[J]. Journal of Kunming Medical University, 2025, 46(2): 95-102. doi: 10.12259/j.issn.2095-610X.S20250214

Citation:

Yuyun YOU, Jinsong YIN, Yunfei HONG, Xia ZHENG, Feifei LIU. The Predictive Value of Changes in Serum Uric Acid and Homocysteine Levels in Patients with Stable Coronary Artery Disease[J]. Journal of Kunming Medical University, 2025, 46(2): 95-102. doi: 10.12259/j.issn.2095-610X.S20250214

Citation:

Yuyun YOU, Jinsong YIN, Yunfei HONG, Xia ZHENG, Feifei LIU. The Predictive Value of Changes in Serum Uric Acid and Homocysteine Levels in Patients with Stable Coronary Artery Disease[J]. Journal of Kunming Medical University, 2025, 46(2): 95-102. doi: 10.12259/j.issn.2095-610X.S20250214

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The Predictive Value of Changes in Serum Uric Acid and Homocysteine Levels in Patients with Stable Coronary Artery Disease

doi: 10.12259/j.issn.2095-610X.S20250214

1.
Department of Medical Imaging，Kunming Municipal Hospital of Traditional Chinese Medicine，Kunming Yunnan 650051
2.
Department of Cardiology，The Third People’s Hospital of Yunnan Province，Kunming Yunnan 650011，China

Received Date: 2024-06-14
Available Online: 2025-01-06
Publish Date: 2025-02-18

Abstract

Abstract

Objective To investigate the predictive value of serum uric acid （UA）, homocysteine （Hcy） and the product index of UA and Hcy in patients with stable coronary artery disease （SCAD）. Methods A total of 783 patients with suspected coronary heart disease were collected, all of whom underwent coronary angiography. Patients were divided into coronary heart disease （CHD） group and non-coronary heart disease （NCHD） group. The CHD group was further divided into low score group （≤ 35 points） and high score group （ > 35 points） according to Gensini scores. Baseline data, blood lipids, Hcy, UA, left ventricular function ultrasound indicators, and comorbidities were collected. Logistic regression analysis was used to evaluate the risk factors associated with the onset of SCAD and severe coronary artery disease, while the Receiver Operating Characteristic （ROC） curve was conducted to assess the predictive efficacy of the product index of UA and Hcy, and related risk factors, for SCAD onset and severe coronary artery disease. Results 1.In CHD group, UA, Hcy and the product index of UA and Hcy were all higher than in the NCHD group （P < 0.001）; the high-score group had higher UA, Hcy and the product index of UA and Hcy than the low Gensini score group （P < 0.001）. 2.Multivariate logistic regression analysis showed that female age, sex, body mass index （BMI）, product index of UA and Hcy, high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C）, left ventricular end-systolic volume （LVESV）, left ventricular ejection fraction （LVEF）, type 2 diabetes mellitus （T2DM） and hypertension （HTN） were independent risk factors for SCAD （P < 0.05）. BMI, the product index of UA and Hcy , HDL-C, LDL-C and LVEF were independent risk factors for severe coronary artery disease （P < 0.05）. 3.There was a positive correlation between UA and Hcy product index and Gensini scores （r = 0.433, P < 0.05）. 4.Receiver operating characteristic curve analysis showed that the product index of UA and Hcy and combined detection of coronary heart disease risk factors had predictive value for the occurrence of SCAD （P < 0.05）, and the predictive value of combined detection was higher （area under the curve 0.808） ; both the product index of UA and Hcy and the combined detection of coronary heart disease risk factors had predictive value for severe coronary artery lesions （P < 0.05）, with a higher predictive value for combined detection （area under the curve 0.771）. Conclusion As an independent predictor of the risk of SCAD and severe coronary stenosis, the product index of UA and Hcy has a high predictive efficacy regarding disease risk and the severity of coronary artery in patients with SCAD.
- Stable angina pectoris,
- Uric acid,
- Homocysteine,
- Product index of uric acid and homocysteine,
- Predictive value

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References(21)

References

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