The Association between miR-146a Gene Polymorphism and Cervical Intraepithelial Neoplasia

Yuhan SHI; Jianghong CHAI; Jinmei XU; Mu LIN; Yufeng YAO; Fengquan HE; Zhiling YAN

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Yuhan SHI, Jianghong CHAI, Jinmei XU, Mu LIN, Yufeng YAO, Fengquan HE, Zhiling YAN. The Association between miR-146a Gene Polymorphism and Cervical Intraepithelial Neoplasia[J]. Journal of Kunming Medical University.

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The Association between miR-146a Gene Polymorphism and Cervical Intraepithelial Neoplasia

Yuhan SHI¹,
Jianghong CHAI²,
Jinmei XU³,
Mu LIN⁴,
Yufeng YAO¹,
Fengquan HE^{5
,
,},
Zhiling YAN^{2, 3
,
,}

1.
Institute of Medical Biology，Chinese Academy of Medical Sciences & Peking Union Medical College，Kunming Yunnan 650118
2.
Department of Obstetrics and Gynecology，The 1st People’s Hospital of Yuanmou County，Yuanmou Yunnan 651300
3.
Department of Gynaecologic Oncology，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118
4.
Department of Laboratory Medicine，Baoshan 2nd People’s Hospital，Baoshan Yunnan 678000
5.
Department of Obstetrics and Gynecology，Maternal and Child Health Hospital of Honghe Prefecture，Honghe Yunnan 661199，China

Received Date: 2024-09-12

Abstract

Abstract

Objective To investigate the association between single nucleotide polymorphisms （SNP） rs57095329 and rs6864584 of miR-146a gene and cervical intraepithelial neoplasia （CIN） in Yunnan Han population. Method A total of 96 patients diagnosed with CIN in the Third Affiliated Hospital of Kunming Medical University were randomly collected as the CIN group, and 225 healthy individuals examined during the same period were selected as the control group using SPSS software. Genotyping of the above SNP loci was performed using the TaqMan probe method. and their correlation with CIN was analyzed. Results The allele and genotype distribution of rs57095329 showed a statistically significant differences compared to the control group. with the frequency of the allele A in the CIN group significantly lower than that in the control group （P < 0.001; OR = 0.48, 95%CI: 0.32～0.70）. In the dominant model, individuals carrying the G allele （A/G-G/G） had a significantly increased risk of CIN （P < 0.001; OR = 2.67, 95%CI: 1.64～4.37）. In contrast, no correlation was found between the rs6864584 and the risk of CIN or histological staging （P > 0.016）. Conclusion The A allele of the miR-146a gene at the rs57095329 locus may be a protective factor for CIN.
- MicroRNAs,
- Cervical intraepithelial neoplasia,
- Single nucleotide polymorphisms,
- Han population in Yunnan

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References(41)

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