Song Yu Feng . Pathologic Changes of Articular Cartilage in Ovariectomied Rats[J]. Journal of Kunming Medical University, 2011, 32(12).
Citation: Song Yu Feng . Pathologic Changes of Articular Cartilage in Ovariectomied Rats[J]. Journal of Kunming Medical University, 2011, 32(12).

Pathologic Changes of Articular Cartilage in Ovariectomied Rats

  • [Abstract]Objective To investigate the effect of osteoporosis on tibia articular cartilage of SD rats,and the relationship between estrogen and the degeneration of articular cartilage.Methods Forty eight-month old SD rats were divided into two groups randomly,one was experiment group,another was control group.Three month later, we got the osteoporosis model successfully. Then the rats were sacrificed at 2 th, 4 th, 8 th, 12 th week.The gross pathology and the immunohistochemistry of collagen,I,Ⅱ,III and sox9 were measured.Results HE staining showed that the number of chondrocytes and cartilage thickness were similar in experiment and control group at 2 th,4 th week.Meanwhile joint surface was smooth and tide lines were integrated.Compared with control group,cartilage thickness became thinner(P<0.05),and the joint surface was locally destroyed in experiment group at 8 th week.Also,tide lines were integrated and the number of chondrocytes were similar.At 12 th week, cartilage thickness were distinctly thinner(P<0.05),the number chondrocytes increased remarkably,joint surface became rough and denudations appeared,tide lines were not integrated in experiment group. Immunohistochemistry staining showed the expression of collagenⅡdecreased sharply at 8 th and 12 th week,the expression of sox9 had no obvious change.Compared with experiment group,Mankin’s grade scale of control group was significantly decreased(P<0.05)at 8 th,12 th week. Conclusion Osteoporosis can affect the articular cartilage structurally,the decrease of estrogen can lead to degeneration of articular cartilage in rats.
  • loading
  • Relative Articles

    [1] Chenrong JIANG, Xuanran ZHOU, Long PU, Yong YUAN. The Efficacy of Two Operative Approaches of Hemiarthroplasty in the Treatmemt of Intertrochanteric Fracture in Elderly Patients. Journal of Kunming Medical University, 2024, 45(1B): 1-6.
    [2] Leijing RAN, Shaohua WANG, Lintong LI, Li GUI. A Meta-analysis of the Effect of Adjuvant Probiotics in Patients with Osteoporosis. Journal of Kunming Medical University, 2024, 45(2): 65-76.  doi: 10.12259/j.issn.2095-610X.S20240209
    [3] Zhengmei PAN, Yanzhi WU, Yan Li, Yiyue ZHAO, Xi HU, Yang LIU. Effects of Estrogen Application Duration in HRT-FET on Pregnancy Outcomes. Journal of Kunming Medical University, 2023, 44(8): 85-90.  doi: 10.12259/j.issn.2095-610X.S20230804
    [4] Gang LI, Shaohua YANG, Meng SHEN, Nan XIE, Guanbo ZHANG, Jiaxing WANG, Jinsong LI. Expression and Clinical Significance of Eukaryotic Translation Initiation Factors 5A2 and Ki67 in Intrahepatic Cholangiocarcinoma. Journal of Kunming Medical University, 2022, 43(6): 7-12.  doi: 10.12259/j.issn.2095-610X.S20220630
    [5] Shao-hua YANG, Zhou-Jun LIAO, Sheng HU, Mao-lin HONG, Zhi-Mei SONG, Qun WEI, Xiao-wen ZHANG. The Expression and Significance of Eukaryotic Translation Initiation Factor-5A2 in Intrahepatic Cholangiocarcinoma. Journal of Kunming Medical University, 2021, 42(5): 24-28.  doi: 10.12259/j.issn.2095-610X.S20210505
    [6] Yong LIAO, Yi-yun GUO, Hong-yu ZHOU, Hai-po FENG, Gen-ding CHEN, Shui-qing YANG. Effects of Folic Acid Combined with Alendronate on Bone Metabolism,CCl4 and Fibroblast Growth Factor Levels in Postmenopausal Osteoporosis Patients. Journal of Kunming Medical University, 2021, 42(7): 98-103.  doi: 10.12259/j.issn.2095-610X.S20210716
    [7] Yu-wei JI, Xin ZHAO, Jiang-li LU, Yi YANG, Wei TANG, Jian-lin JIAO. Effect of Osteoking on Bone Density and Bone Biomechanics of Tree Shrews in a Postmenopausal Osteoporotic Fracture Model. Journal of Kunming Medical University, 2020, 41(11): 7-11.  doi: 10.12259/j.issn.2095-610X.S20201103
    [8] Li Li , Zeng Yue Qin , Li Jin Tao , Zhao Hong Bin , Liang Zhang , Wang Li Mei . . Journal of Kunming Medical University, 2019, 40(07): 15-18.
    [9] Li Na , Fang Hong Li , Deng Li. . Journal of Kunming Medical University, 2019, 40(06): 135-139.
    [10] Jie Chun Lin , Yue Qiao Ning , Teng Zhao Wei . . Journal of Kunming Medical University, 2019, 40(01): 1-5.
    [11] Du Shi Gang , Zhao Ling , Pu Meng Xian , Pan Yi , Du Juan , Ke Ting Yu . . Journal of Kunming Medical University, 2018, 39(12): 43-48.
    [12] Zhao Zheng Xing . Clinical Efficacy of PFNA Internal Fixation in the Treatment of 40 Osteoporotic Intertrochanteric Fractures. Journal of Kunming Medical University,
    [13] Yang Feng . Establishment of Tree Shrew Osteoporosis Model by Bilateral Ovariectomy. Journal of Kunming Medical University,
    [14] Li Li . Effect of Geraniin on Expression of Wnt3a in BMSC from Osteoporotic Rats. Journal of Kunming Medical University,
    [15] Ke Ting Yu . . Journal of Kunming Medical University,
    [16] Yang Man . . Journal of Kunming Medical University,
    [17] Han Di . . Journal of Kunming Medical University,
    [18] Yuan Xiao Feng . . Journal of Kunming Medical University,
    [19] Zhang Xiao Chao . . Journal of Kunming Medical University, 2012, 33(08): 1-1.
    [20] Ma Jin Xia . . Journal of Kunming Medical University,
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2354) PDF downloads(65) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return