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Huang Min Jie . Biotransformation of Corynoxeine and Isocorynoxeine in Rats[J]. Journal of Kunming Medical University, 2012, 33(10).
Citation: Huang Min Jie . Biotransformation of Corynoxeine and Isocorynoxeine in Rats[J]. Journal of Kunming Medical University, 2012, 33(10).
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Biotransformation of Corynoxeine and Isocorynoxeine in Rats

    Abstract
  • ［Abstract］Objective　To investigate the biotransformation of Corynoxeine and Isocorynoxeine in Rats． Methods　Corynoxeine and isocorynoxeine were administered orally to rats， and the bile samples of rats were collected to analyze by LC-MS．Results　It was found for the bile samples taken for first 30 mins that two phase I metabolites and two phase II ones were detected for corynoxeine by LC-MS．However for isocorynoxeine there were 4 phase II metabolites found but no phase I ones in the same sample．Conclusions　There is a hepatic first-pass effect after their oral administration. According to analysis of samples in vivo and in vitro by LC-MS and comparison with the fate of rhynchophylline and isorhynchophylline in rats，corynoxeine and isocorynoxeine seem to have a similar biotransformation．Also incubation of the substrates with rat liver microsomes show that CYP450 plays a key role in their metabolic catalysis.
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