Yang Jie . Comparison of S-1 Combined with Radical Radiation Therapy and Single Radical Radiation Therapy in Treatment of Early Nasopharyngeal Carcinoma[J]. Journal of Kunming Medical University, 2012, 33(10).
Citation: Yang Jie . Comparison of S-1 Combined with Radical Radiation Therapy and Single Radical Radiation Therapy in Treatment of Early Nasopharyngeal Carcinoma[J]. Journal of Kunming Medical University, 2012, 33(10).

Comparison of S-1 Combined with Radical Radiation Therapy and Single Radical Radiation Therapy in Treatment of Early Nasopharyngeal Carcinoma

  • [Abstract]Objective To explore the curative effect and toxicity of radical radiation therapy combined with S-1 for early nasopharyngeal carcinoma.Methods From Jan.1st 2009 to Jan.1st 2010,88 cases of early early nasopharyngeal carcinoma were divided into two groups: the joint S-1 and radiotherapy group(experimental group) and the single radiotherapy group(control group), and 44 cases in each group. Patients in the control group only received radiation therapy,they were adopted ordinary radiation therapies,five times a week,2.0 Gy each time, total dose was 60 ~ 66 Gy.Patients in the experimental group took S-1 capsules orally while receiving radiation therapy, the initial dose was 65 mg/(m.d),bid,d1~d28 and the intermittent period was twoweeks.Results All of the 88 patients completed treatment, and were evaluated as CR,the effective rate was 100%.2-year local control rates were 100%(44 / 44)for experimental group and 90.9%(40/44)for control group,there was significant difference(P<0.05)between two groups.The main side effects were myelosuppression and gastrointestinal reactions.Conclusions Radiation therapy combined with S-1 get higher local control ratio than single radiation therapy.But the long-term outcomes and toxicities need to be further investgated.
  • loading
  • Relative Articles

    [1] Shengxi YANG, Jiade ZHU, Qiurui LI, Wenlian TU. Clinical Study of Aumolertinib Versus Osimertinib in the Treatment of EGFR-Mutated Advanced Non-Small Cell Lung Cancer. Journal of Kunming Medical University, 2025, 46(5): 1-7.
    [2] Ling MA, Yanhong ZHAO, Jia LIU, Wenlian TU. Cost-Effectiveness Analysis of Nilotinib Versus Dasatinib as Second-Line Treatment of Chronic Myeloid Leukemia. Journal of Kunming Medical University, 2024, 45(4): 92-98.  doi: 10.12259/j.issn.2095-610X.S20240413
    [3] Jing LIU, Mei YAN, Yashuang CHEN, Liyu DU, Sisi HUANG. Survey and Analysis of Supportive Care Needs of Patients after Radical Breast Cancer Surgery based on Kano Model. Journal of Kunming Medical University, 2023, 44(11): 188-194.  doi: 10.12259/j.issn.2095-610X.S20231129
    [4] Zhao Shu Bo , Li Ai Lin , Liang Wu , Ning Jin Mei . . Journal of Kunming Medical University, 2020, 41(08): 105-110.
    [5] Jiang ZHANG, Yan LIU, Wen-hui LI, Xi-juan ZHAO, Zheng-ting CHEN, Qiong-yao GUAN, Jiang WU. Effects of Pre-sleep Music Therapy on Sleep Quality and Cancer-related Fatigue in Patients with Breast Cancer Undergoing Radiotherapy. Journal of Kunming Medical University, 2020, 41(12): 173-178.  doi: 10.12259/j.issn.2095-610X.S20201248
    [6] Zhang Zhi Xian , Gu Hou , Feng Xin Rong , Lin 劼, Lei Xue Fen , Li Nan , Li Rui Zhi , Yu Jia . . Journal of Kunming Medical University, 2020, 41(05): 70-74.
    [7] Zhang Zhi Xian , Gu Hou , Lin 劼, Lei Xue Fen , Jiang Li Feng , Li Nan , Lu Xin Yan , Yu Jia . . Journal of Kunming Medical University, 2019, 40(08): 97-101.
    [8] Zhang Zhi Xian , Gu Hou , Lin 劼, Lei Xue Fen , Jiang Li Feng , Li Nan , Lu Xin Yan . . Journal of Kunming Medical University, 2019, 40(02): 123-127.
    [9] Jiang Bo , Lin Chao . The Effect of Oxaliplatin Injection Combined with S-1 on Levels of CEA, CA199, TAM and the Quality of Life of Patients with Advanced Gastric Cancer. Journal of Kunming Medical University, 2018, 39(01): 113-117.
    [10] Chen Hong Zhi , Kang Hua Feng , Yi Chun Xi , Yang Le . Comparison of Efficacy and Safety of Concurrent Radiotherapy and Chemotherapy in Treatment of Invasive Carcinoma of Cervix. Journal of Kunming Medical University, 2017, 38(04): 68-71.
    [11] Lu Xi Wei . Clinical Effects of Cisplatin Combined with Temozolomide and Radiotherapy in Treatment of Glioblastomas after Surgery. Journal of Kunming Medical University,
    [12] Xu Xiao Hong . Clinical Analysis of Preoperative Neoadjuvant Chemotherapy by Thalidomide Combined with Gefitinib for Non-small Cell Lung Cancer. Journal of Kunming Medical University,
    [13] Long Xiang Yu . . Journal of Kunming Medical University,
    [14] Wang Hua . . Journal of Kunming Medical University,
    [15] Wu Xue Song . . Journal of Kunming Medical University,
    [16] An Zhi . . Journal of Kunming Medical University,
    [17] Niu Hua Tao . . Journal of Kunming Medical University,
    [18] Yang Jie . Clinical Application of I125-seed Implantation Combined with Gimeracil and Oteracil Capsules Adjuvant Chemotherapy in the Treatment of Head and Neck Cancer. Journal of Kunming Medical University,
    [19] Niu Hua Tao . Three-dimensional Conformal Radiotherapy with Temozolomide in the Treatment of Postoperative Malignant Gliomas. Journal of Kunming Medical University,
    [20] Tan Jing . . Journal of Kunming Medical University,
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (3921) PDF downloads(1187) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return