Effect of Water Extract from Salvia Miltiorrhiza on the Hair Regrowth in Testosterone-induced Alopecia in Mice

Zhang Zhi Bi; Dong Chao; Ma Jiao; Feng Guo Hua

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Article Navigation > Journal of Kunming Medical University > 2016 > 37(11): 23-27

Zhang Zhi Bi , Dong Chao , Ma Jiao , Feng Guo Hua . Effect of Water Extract from Salvia Miltiorrhiza on the Hair Regrowth in Testosterone-induced Alopecia in Mice[J]. Journal of Kunming Medical University, 2016, 37(11): 23-27.

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Zhang Zhi Bi , Dong Chao , Ma Jiao , Feng Guo Hua . Effect of Water Extract from Salvia Miltiorrhiza on the Hair Regrowth in Testosterone-induced Alopecia in Mice[J]. Journal of Kunming Medical University, 2016, 37(11): 23-27.

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Effect of Water Extract from Salvia Miltiorrhiza on the Hair Regrowth in Testosterone-induced Alopecia in Mice

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基金：云南省自然科学基金资助项目(2014FB060); 云南省教育厅科研基金重点项目(2013Z112);

Received Date: 2016-04-14

Abstract

Abstract

Objective To study the role of water exact from salvia miltiorrhiza(SM) in promoting hair regrowth in testosterone(T)-induced alopecia in mice. Methods Pathological alopecia mice were induced by T and the mice were randomly divided into control group, model group, Zhanggvanp 101 group, SM low-dose group,SM middle-dose group,SM high-dose group(20, 40, 80 mg/ml, respectively). The effects of SM on hair regrowth were evaluated by measuring hair length, weight and the number of hair follicle. The concentration of serum T and estrodiol(E2), the content of skin VEGF, MDA, SOD, and GSH-Px were measured after external inunctum for 21 days. Results(1) SM significantly promoted regrowth hair length, weight and the number of hair follicle(P<0.05).(2) SM significantly balanced the hormones by reducing levels of T and increasing E2(P<0.05).(3) SM significantly reduced the content of MDA by increasing the activity of SOD and GSH-Px(P<0.05).(4) SM significantly increased the level of VEGF(P<0.05). Conclusion In the pathological alopecia mice induced by T, SM can effectively promote the hair regrowth, with the possible mechanism of balancing hormones, being anti-oxidant and improving VEGF expression.
- Water exact from salvia miltiorrhiza,
- Androgeneic alopecia,
- Hair regrowth,
- Testosterone

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References(19)

References

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