Expression of IL-17 and IL-23 in Patients with B-cell non-HodgkinLymphoma Treated by RCHOP

Huang Ying; Liu Yi Han; Li Cheng Ping; Wu Kun; Zeng Yun

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Huang Ying , Liu Yi Han , Li Cheng Ping , Wu Kun , Zeng Yun . Expression of IL-17 and IL-23 in Patients with B-cell non-HodgkinLymphoma Treated by RCHOP[J]. Journal of Kunming Medical University, 2016, 37(12): 76-81.

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Huang Ying , Liu Yi Han , Li Cheng Ping , Wu Kun , Zeng Yun . Expression of IL-17 and IL-23 in Patients with B-cell non-HodgkinLymphoma Treated by RCHOP[J]. Journal of Kunming Medical University, 2016, 37(12): 76-81.

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Expression of IL-17 and IL-23 in Patients with B-cell non-HodgkinLymphoma Treated by RCHOP

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基金：云南省教育厅科学研究基金资助项目(2013Y292);

Received Date: 2016-08-29

Abstract

Abstract

Objectives To study the role of IL-17 and IL-23 in non-Hodgkin lymphoma(NHL) by detecting the expression levels of IL-17 and IL-23 in peripheral blood of B-cell non-Hodgkin lymphoma patients treated by RCHOP.Methods T wenty-five patients with B-cell NHL who achieved remission after 6 to 8 cycles of R-CHOP as a NHL group,20 healthy volunteers were recruited as a normal control group.RT-PCR was used to detect the expression levels of IL-17 m RNA and IL-23 m RNA in NHL patients and health volunteers.Results The expression level of IL-17 m RNA and IL-23 m RNAin the patients with NHL before therapy and the patients with NHL who achieved remission was lower than that in the normal control group(P<0.05).The expression level of IL-17 m RNA and IL-23 m RNA in the patients with NHL who achieved remission was higher than that in the patients with NHL before therapy(P=0.001,P<0.05).Conclusion IL-17 and IL-23 m RNA expressions are higher after treated with R-CHOP.The expression levels of IL-17 m RNA and IL-23 m RNA in NHL patients are related with prognosis and efficacy.
- Non-Hodgkin lymphoma,
- Interleukin-17,
- Interleukin-23,
- Rituximab,
- Prognosis

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References(19)

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