Association Study of TNF-α and ALCAM Polymorphisms with Chronic HCV Infection in Yunnan Han Population

［Abstract］Objective To discuss the association of allele polymorphisms SNP-rs1799724 （C＞T） in the TNF-α and SNP-rs11559013（G＞A） in the ALCAM with HCV chronic infection in Han population in Yunnan province. Methods 434 HCV chronic infectious patients and 444 healthy individuals of Han Chinese population in Yunnan province were recruited. Two single nucleotide polymorphisms （SNPs） in the SNP-rs1799724（C＞T） of TNF-α gene and SNP-rs11559013（G＞A）of ALCAM gene were determined by real-time TaqMan polymerase chain reaction. We evaluated the associations of the two SNPs with HCV chronic infection. Results The distributions of allele and genotype of SNP-rs1799724（C＞T） in the TNF-α and SNP-rs11559013（G＞A）in the ALCAM between hepatitis C virus （HCV） chronic infectious patients and the healthy controls were not statistically significant （P > 0.05）. Conclusion SNP-rs1799724（C＞T） in the TNF-α and SNP-rs11559013（G＞A） in the ALCAM have no association with HCV chronic infection in the Han population in Yunnan province.