Expressions of Let-7 in Normal Breast Tissue and Breast Cancer Tissue

Yu Jian

Volume 37 Issue 07

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Article Navigation > Journal of Kunming Medical University > 2016 > 37(07):

Wenyu YANG, Likun ZHOU, Yan TANG, Weiping ZHANG. Application Value of Magnetic Resonance Diffusion-Weighted Imaging and Arterial Spin Markers in the Diagnosis of Acute Cerebrovascular Disease[J]. Journal of Kunming Medical University, 2022, 43(4): 70-74. doi: 10.12259/j.issn.2095-610X.S20220413

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Yu Jian . Expressions of Let-7 in Normal Breast Tissue and Breast Cancer Tissue[J]. Journal of Kunming Medical University, 2016, 37(07).

Citation:

Yu Jian . Expressions of Let-7 in Normal Breast Tissue and Breast Cancer Tissue[J]. Journal of Kunming Medical University, 2016, 37(07).

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Expressions of Let-7 in Normal Breast Tissue and Breast Cancer Tissue

Yu Jian

(1)School of Public Health,Kunming Medical University,Kunming Yunnan 650500;2)Dept. of Cardio-Thoracic Surgery,The Third Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650118;3)Dept. of General Surgery,Kunming General Hospital of Chengdu Military Region,Kunming Yunnan 650031, China)

Abstract

Abstract

［Abstract］Objective　To study the expression characteristics of Let-7 genes in breast cancer. Methods Twenty-eight patients with breast cancer were randomly selected，and their cancer tissue and adjacent normal tissue were collected. TRIzol was used to extract the total RNA and real-time quantitative PCR was used to detect the relative gene expression levels. Results The expression of precursor Let-7 in cancer tissue was（9.65±2.31），which was lower than that in normal tissue（10.05±2.81 ），P = 0.048. Precursor Let-7 had dependence relationship with the long menstruation（b = 0.816，P = 0.029）. The menarche age showed a positive correlation with precursor Let-7 in normal tissue（r = 0.502，P = 0.048）and a negative correlation in cancer tissue（r = -0.484，P = 0.049）. Conclusions The expression of precursor Let-7 in cancer tissue is lower than that in normal tissue. The period of menstruation is a protective factor to breast cancer.
- ［Key words］Breast cancer；Let-7；Gene,

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