Effects of Yunnan BaiYao on the Expressions of c-fos and C-jan mRNA in Periodontal Ligament Cells in Vitro

Chu Wen

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Chu Wen . Effects of Yunnan BaiYao on the Expressions of c-fos and C-jan mRNA in Periodontal Ligament Cells in Vitro[J]. Journal of Kunming Medical University, 2016, 37(09).

Citation:

Chu Wen . Effects of Yunnan BaiYao on the Expressions of c-fos and C-jan mRNA in Periodontal Ligament Cells in Vitro[J]. Journal of Kunming Medical University, 2016, 37(09).

Chu Wen . Effects of Yunnan BaiYao on the Expressions of c-fos and C-jan mRNA in Periodontal Ligament Cells in Vitro[J]. Journal of Kunming Medical University, 2016, 37(09).

Citation:

Chu Wen . Effects of Yunnan BaiYao on the Expressions of c-fos and C-jan mRNA in Periodontal Ligament Cells in Vitro[J]. Journal of Kunming Medical University, 2016, 37(09).

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Effects of Yunnan BaiYao on the Expressions of c-fos and C-jan mRNA in Periodontal Ligament Cells in Vitro

Chu Wen

(Dept. of Oral Preventive Medicine,The 2nd People’s Hospital of Yunnan Province,Kunming Yunnna 650021,China)

Abstract

Abstract

［Abstract］Objective　To study the effects of Yunnan BaiYao on the expressions of c-fos and c-jun mRNA in HPDLFs and explore the potential mechanism that Yunnan BaiYao promotes the proliferation and differentiation of HPDLFs．Methods　The HPDLFs tissue was obtained from the extracted healthy premolar．The HPDLFs used underwent four to six passages．Cells were divided into untreated group， positive control group and treated group. In treated group，HPDLFs were co-cultured with Yunnan BaiYao solution for 4h with gradient concentration. The expressions of c-fos and c-jun mRNA were determined by RT-PCR．Results　The results showed that the expressions of c-fos and c-jun mRNA were up-regulated significantly in treated group compared with control group（P＜0.05）．Conclusion　Yunnna BaiYao can upregulate the expressions of c-fos and C-jun mRNA in HPDLFs. Through upregulating the expressions of c-fos and c-jun mRNA in hPDLs，Yunnan BaiYao can promote proliferation and differentiation of ossification of HPDLFs to induce bone formation.
- ［Key words］Yunnna BaiYao；Human periodontal ligament cells；C-fos；C-jun；Proliferation and differentiation,

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