Effects of Multimodal Analgesia on Cytokines and Cortisol Levels in Patients Received Surgical Treatment for Radical Colon Cancer

Yang Jian Zhi

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Yang Jian Zhi . Effects of Multimodal Analgesia on Cytokines and Cortisol Levels in Patients Received Surgical Treatment for Radical Colon Cancer[J]. Journal of Kunming Medical University, 2016, 37(09).

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Yang Jian Zhi . Effects of Multimodal Analgesia on Cytokines and Cortisol Levels in Patients Received Surgical Treatment for Radical Colon Cancer[J]. Journal of Kunming Medical University, 2016, 37(09).

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Effects of Multimodal Analgesia on Cytokines and Cortisol Levels in Patients Received Surgical Treatment for Radical Colon Cancer

Yang Jian Zhi

(1)Dept. of Anesthesiology,Central Hospital of Hanzhong,Hanzhong Shaanxi 723000;2)Medical School of Xi’an Jiaotong University, Xi’an Shaanxi 710004,China)

Abstract

Abstract

［Abstract］Objective　To investigate effects of multimodal analgesia on cytokines and cortisol levels in patients received surgical treatment for radical colon cancer. Methods　Eighty-six patients with radical colon cancer treated with surgery were randomly divided into control group and observation group. The control group only received routine epidural anesthesia and the observation group received multimodal analgesia. Preoperative and postoperative VAS scores，cytokines and cortisol levels were measured. Results　Compared with those of the control group，the following 5 indicators decreased significantly in the observation group including VAS scores of after 24 h，48 h，72 h， IL-8 and TNF-α after 24 h，IL-6，IL-8 and TNF-α after 48 h， Cor after 24h，and Cor and ACTH after 48 h（P＜0.05）. Conclusion　Perioperative multi-mode analgesia helps relieve pain，stress and inflammatory cytokines among patients after the surgery for radical colon cancer.
- ［Key words］Multimodal analgesia；Cortisol；Inflammatory factors；Radical colon cancer surgery,

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