Comparation of Three Kinds of Diterpenoid Alkaloid from Aconitum bulleyanum Diels in Related Pharmacodynamics and Toxicity

Hai Qing Shan; Ma Xiao Xia; Yang Yu Qing; Yang Zhu Ya

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Hai Qing Shan , Ma Xiao Xia , Yang Yu Qing , Yang Zhu Ya . Comparation of Three Kinds of Diterpenoid Alkaloid from Aconitum bulleyanum Diels in Related Pharmacodynamics and Toxicity[J]. Journal of Kunming Medical University, 2017, 38(01): 18-22.

Citation:

Hai Qing Shan , Ma Xiao Xia , Yang Yu Qing , Yang Zhu Ya . Comparation of Three Kinds of Diterpenoid Alkaloid from Aconitum bulleyanum Diels in Related Pharmacodynamics and Toxicity[J]. Journal of Kunming Medical University, 2017, 38(01): 18-22.

Citation:

Hai Qing Shan , Ma Xiao Xia , Yang Yu Qing , Yang Zhu Ya . Comparation of Three Kinds of Diterpenoid Alkaloid from Aconitum bulleyanum Diels in Related Pharmacodynamics and Toxicity[J]. Journal of Kunming Medical University, 2017, 38(01): 18-22.

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Comparation of Three Kinds of Diterpenoid Alkaloid from Aconitum bulleyanum Diels in Related Pharmacodynamics and Toxicity

Funds:

基金：云南省科技厅应用基础研究基金资助项目 (2011FZ159);

Received Date: 2016-09-10

Abstract

Abstract

Objective To investigate the anti-inflammatory and analgesic activity and acute toxicity of Bulleyaconitine A and Foresaconitine and Yunaconitine from Aconitum bulleyanum Diels.Methods After intragastric administration, the anti-inflammatory and analgesic activities of Bulleyaconitine A and Foresaconitine and Yunaconitine using Acetic acid writhing test and Dimethylbenzene auricle swelling test in mice were compared.The acute toxicities of three iterpenoidalkaloids were also compared according to LD50.Results (1) The LD50 values of Bulleyaconitine A and Foresaconitine and Yunaconitine were:4.06 mg/kg, 2.81 mg/kg and 12 mg/kg; (2) Single intragastric administration of three kinds of alkaloids all had obvious inhibitory effect on acetic acid-induced writhing pain.The 2 mg/kg group of Bulleyaconitine A had the strongest effect, the inhibition rate was higher than the same dose of Foresaconitine and Yunaconitine, there was significant difference compared with Foresaconitine group (P<0.05) ; (3) Bulleyaconitine A and Yunaconitine had obvious inhibiting effect on auricle swelling induced by dimethylbenzene, there were significant differences compared with the vehicle group (P <0.05) , Foresaconitine with the same dose had no obvious effect; 0.4 mg/kg Yunaconitine had the strongest anti-inflammatory effects, there were significant differences compared with the same dose of Bulleyaconitine A and Foresaconitine groups ( P <0.01) .Conclusion ( 1) Comparison of acute toxicity: Yunaconitine >Bulleyaconitine A >Foresaconitine; (2) Three alkaloids all have analgesic effects in different degree, Bulleyaconitine A is the strongest; (3) Yunaconitine is better than Bulleyaconitine A and Foresaconitine in anti-inflammatory effect with same concentration.
- Aconitum bulleyanum Diels,
- Diterpenoidalkaloid,
- Anti-inflammatory,
- Analgesic,
- Acute toxicity

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References(14)

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