The Effectiveness and Safety of Celecoxib in Treatment of Female Stress Urinary Incontinence

Li Jiang; Liu Shang; Chen Wei Kang; Zhang Wei; Fang Ke Wei

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Li Jiang , Liu Shang , Chen Wei Kang , Zhang Wei , Fang Ke Wei . The Effectiveness and Safety of Celecoxib in Treatment of Female Stress Urinary Incontinence[J]. Journal of Kunming Medical University, 2017, 38(01): 70-74.

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Li Jiang , Liu Shang , Chen Wei Kang , Zhang Wei , Fang Ke Wei . The Effectiveness and Safety of Celecoxib in Treatment of Female Stress Urinary Incontinence[J]. Journal of Kunming Medical University, 2017, 38(01): 70-74.

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The Effectiveness and Safety of Celecoxib in Treatment of Female Stress Urinary Incontinence

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2015FA007); 昆明医科大学科技创新团队建设基金资助项目 (CXTD201618) ;昆明医科大学研究生创新基金资助项目 (2016s104);

Received Date: 2016-10-20

Abstract

Abstract

Objective To explore the effectiveness, safety and the possible mechanism of Celecoxib Capsules (Celebrex) in treatment of female stress urinary incontinence.Methods From January 2014 to December 2015, 80 female patients with stress urinary incontinence, from the outpatient department of our hospital, were selected in experimental group, who took celecoxib orally 200 mg, Bid for 3 months.The other 80 female patients with stress urinary incontinence were selected in control group, who took placebo (medical starch) orally 1 piece, Bid for 3 months.The two groups of patients were treated with behavioral therapy and functional exercise of pelvic floor.Both groups of patients were assessed with the urine pad test and quality of life scale 3months later.The study was approved by the Institutional Review Board of the second Hospital of Kunming Medical University and followed the principles expressed in the Declaration of Helsinki.The written informed consent was obtained from every patient.Results The difference between the experimental group and the control group in the age, the course of disease had no statistical significance (P>0.05) .The effectiveness of experimental goup was better than the controlled group.The urine volume in experimental group is less than that in control group in urine pad test.And the score of experimental goup in QOL-36-SF was higher than that of control group both in physical dimension and the psychological dimension.The overall effective rate was 96.3% in experimental group [21 (26.3%) cases were improved markedly, 56 (70%) patients improved, 3 (3.8%) patients was failed] and88.6% in control group [15 (18.8%) cases were improved markedly, 56 (70%) patients improved, 3 (3.8%) patients was failed].Tthe difference has statistical significance (P<0.05) .No obvious side effects were observed in both groups and no one stooped the treatment by herself.Conclusion Celecoxib can attenuate the symptoms of female stress urinary incontinence, and has the good safety and tolerability.
- Cyclooxygenase 2 inhibitor (COX-2) ,
- Stress urinary incontinence (SUI) ,
- Drug therapy,
- Detrusor,
- Urethral sphincter,
- Micturition reflex

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References(22)

References

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