Clinical Analysis of Transcatheter Arterial Chemoembolization Combined with Intensity Modulated Radiotherapy Therapy for Patients with Primary Hepatic Carcinoma

Gao Jing Yan; Chen Fu Kun; Yan Jia Wen; Wang Jia Ping

Volume 38 Issue 01

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Gao Jing Yan , Chen Fu Kun , Yan Jia Wen , Wang Jia Ping . Clinical Analysis of Transcatheter Arterial Chemoembolization Combined with Intensity Modulated Radiotherapy Therapy for Patients with Primary Hepatic Carcinoma[J]. Journal of Kunming Medical University, 2017, 38(01): 95-98.

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Gao Jing Yan , Chen Fu Kun , Yan Jia Wen , Wang Jia Ping . Clinical Analysis of Transcatheter Arterial Chemoembolization Combined with Intensity Modulated Radiotherapy Therapy for Patients with Primary Hepatic Carcinoma[J]. Journal of Kunming Medical University, 2017, 38(01): 95-98.

Citation:

Gao Jing Yan , Chen Fu Kun , Yan Jia Wen , Wang Jia Ping . Clinical Analysis of Transcatheter Arterial Chemoembolization Combined with Intensity Modulated Radiotherapy Therapy for Patients with Primary Hepatic Carcinoma[J]. Journal of Kunming Medical University, 2017, 38(01): 95-98.

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Clinical Analysis of Transcatheter Arterial Chemoembolization Combined with Intensity Modulated Radiotherapy Therapy for Patients with Primary Hepatic Carcinoma

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基金：云南省科技厅应用基础研究基金资助项目 (2009ZC111M); 云南省教育厅科学研究基金资助项目 (09Z0034);

Received Date: 2016-10-20

Abstract

Abstract

Objective To evaluate the efficacy of transcatheter arterial chemoembolization (TACE) in combination with intensity modulated radiotherapy (IMRT) in treatment of primary hepatic carcinoma (PHC) .Methods All 68 patients with PHC were randomized into treatment group (TACE plus IMRT) and control group (TACE alone) , with 34 cases in each group.Patients in the control group were treated with interventional therapy alone.Patients in the treatment group were treated with interventional therapy (transcatheter arterial chemoembolization) plus radiotherapy.Treatment group patients firstly received 2 to 3 times interventional therapy, then followed by radiotherapy with 2 to 4 week interval.Results The short-term efficacy was 82.4% in treatment group which was significantly higher than 61.8% in control group (P<0.05) .The survival rate was 76.5% in 1 year and55.9% in 2 years in treatment group, 58.9% and 32.4% in control group respectively.The difference between 2group was statistical significance (P<0.05) No serious toxicities were observes in the patients of the two groups.Conclusion The results suggest that the treatment effect of TACE plus IMRT is better than interventional therapy alone for patients with primary Hepatic carcinoma, and has well tolerance and fewer adverse reactions.
- Primary hepatic carcinoma (PHC) ,
- Radiotherapy,
- Interventional therapy,
- Transcatheter arterial chemoembolization (TACE) ,
- Intensity modulated radiotherapy (IMRT)

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