The Role of Singal Pathways in Osteoarthritis

Li Long Teng; Li Yan Lin; Wang Kun; Xiao Yu; Yan Xiang Jia

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Li Long Teng , Li Yan Lin , Wang Kun , Xiao Yu , Yan Xiang Jia . The Role of Singal Pathways in Osteoarthritis[J]. Journal of Kunming Medical University, 2017, 38(04): 137-141.

Citation:

Li Long Teng , Li Yan Lin , Wang Kun , Xiao Yu , Yan Xiang Jia . The Role of Singal Pathways in Osteoarthritis[J]. Journal of Kunming Medical University, 2017, 38(04): 137-141.

Li Long Teng , Li Yan Lin , Wang Kun , Xiao Yu , Yan Xiang Jia . The Role of Singal Pathways in Osteoarthritis[J]. Journal of Kunming Medical University, 2017, 38(04): 137-141.

Citation:

Li Long Teng , Li Yan Lin , Wang Kun , Xiao Yu , Yan Xiang Jia . The Role of Singal Pathways in Osteoarthritis[J]. Journal of Kunming Medical University, 2017, 38(04): 137-141.

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The Role of Singal Pathways in Osteoarthritis

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基金：国家自然科学基金资助项目(81460340); 云南省创新团队基金资助项目(2014HC018); 云南省医疗卫生单位内设研究机构基金资助项目(2014NS161);

Received Date: 2016-11-14

Abstract

Abstract

Osteoarthritis is the chronic articulatio-synovialis disease which features as cartilage degenerate and secondary osteoproliferation. Current pharmacologic therapy is largely ineffective at altering progression of the disease because the varitious mechanisms for OA remain elusive. The various therapeutic method of OA are not obvious,just relieve symptom or improve the function of joints in short.It is imposbille to stop pathological process of OA, not to mention reverse the degeneration of cartilage.It is a hot study between singal pathway and osteoarthritis,mroe and more researches confirm that the singal pathway of SDF-1/CXCR4,MAPK,Wnt,OPG/RANKL/RANK etc have close association with the generation and progress of OA.However, none of the singgal pathways can completely explan the mechanism of OA,or cure OA by block any singal pathway.So it is hotop to study mechanisms of OA and mew drugs.This rewiew focuses on singal pathway to OA in internation, hope to support theoretical foundation for study and therapy of OA
- Osteoarthritis,
- Signal pathway,
- SDF-1,
- CXCR4,
- MAPK

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References(36)

References

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