Clinical Curative Effect of Differentiated Thyroid Carcinoma Treated by Using Large 131I and 1st Influencing Factors

Feng Zhi Ping; Deng Zhi Yong; Song Yuan Hua; Yang Chuan Zhou; Liu Chao

Article Contents

Article Navigation > Journal of Kunming Medical University > 2017 > 38(04): 72-75

Feng Zhi Ping , Deng Zhi Yong , Song Yuan Hua , Yang Chuan Zhou , Liu Chao . Clinical Curative Effect of Differentiated Thyroid Carcinoma Treated by Using Large 131I and 1st Influencing Factors[J]. Journal of Kunming Medical University, 2017, 38(04): 72-75.

Citation:

Feng Zhi Ping , Deng Zhi Yong , Song Yuan Hua , Yang Chuan Zhou , Liu Chao . Clinical Curative Effect of Differentiated Thyroid Carcinoma Treated by Using Large 131I and 1st Influencing Factors[J]. Journal of Kunming Medical University, 2017, 38(04): 72-75.

Citation:

Feng Zhi Ping , Deng Zhi Yong , Song Yuan Hua , Yang Chuan Zhou , Liu Chao . Clinical Curative Effect of Differentiated Thyroid Carcinoma Treated by Using Large 131I and 1st Influencing Factors[J]. Journal of Kunming Medical University, 2017, 38(04): 72-75.

PDF( 0 KB)

Clinical Curative Effect of Differentiated Thyroid Carcinoma Treated by Using Large 131I and 1st Influencing Factors

Funds:

基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(2013FB170);

Received Date: 2016-11-13

Abstract

Abstract

Objective To retrospectively analyze the curative effect of 131I therapy for treating post-operative differentiated thyroid carcinoma( DTC) and the influencing factors. Methods Two hundred and sixteen post-operative DTC patients who had received 131I therapy were involved in this retrospective study. The efficacy was assessed by 131I whole body scan in four days after the therapy every time. Besides,the overall curative effect was observed according to patients' pathological type,location of metastasis and frequency of 131I therapy respectively.Results After high dose 131I treatment, the total effective rate in patients with was 86.57%. The curative effect on cervical lymph node metastasis of DTC was significantly better than that of lung metastasis and bone metastasis.Meanwhile, no obvious side effects were observed during the study.Conclusions Large dose of 131I therapy for DTC metastasis is safe and effective. The location of tumor metastasis may influence the curative effect.
- Differentiated thyroid cancer,
- 131I odine,
- Therapeutics

FullText(HTML)

References(25)

References

[1]	[1]SAMPSON E,BRIERLEY J D,LE L W,et al.Clinical management and outcome of papillary and follicular(differentiated)thyroid cancer presenting with distant metastasis at diagnosis[J].Cancer,2007,110(7):1451-1456.
[2]李磊,冀叶,孙瑞梅,等.2003年至2011年云南省肿瘤医院头颈部恶性肿瘤病谱分析[J].昆明医科大学学报2012,33(9):66-69.
[3]	[3]LEE J,SOH EY.Differentiated thyroid carcinoma presentingwith distant metastasis at initial diagnosis clinical outcomes and prognostic factors[J].Ann Surg,2010,251(1):114-119.
[4]	[4]HOGAN A R,ZHUGE Y,PEREZ E A,et al.Pediatric thyroid carcinoma:Incidence and outcomes in 1753 patients[J].J Surg Res,2009,156(1):167-172.
[5]	[5]MALLICK U,HARMER C,YAP B,et al.Ablation with low-dose radioiodine and thyrotropin alfa in thyroid cancer[J].N En-gl J Med,2012,366(18):1674-1685.
[6]	[6]SCHLUMBERGER M,CATARGI B,BORGET I,et al.Strategies of radioiodine ablation in patients with low-risk thyroid cancer[J].N Engl J Med,2012,366(18):1663-1673.
[7]张超杰,范培芝,张志功,等.碘131治疗分化型甲状腺癌误区的认识与思考[J].医学与哲学,2012,33(20):17-20.
[8]	[8]IBRAHIMPASIC T,NIXON I J,PALMER F L,et al.Undetectable thyroglobulin after total thyroidectomy in patients with low-and intermediate-risk papillary thyroid cancer is there a need for radioactive iodine therapy[J].Surgery,2012,152(6):1096-1105.
[9]李镜发,邹德环,佘立群,等.甲状腺癌术后大剂量131I治疗疗效分析[J].中华实用诊断与治疗杂志,2013,27(2):129-133.
[10]李志红.促甲状腺激素抑制疗法在分化型甲状腺癌治疗中的作用[J].实用临床医药杂志,2013,17(9):107-108.
[11]	[11]MIHAILOVIC J,STEFANOVIC L,STANKOVIC R.Influence of initialtreatment on the survival and recurrence in patients with differentiated thyroid microcarcinoma[J].Clin Nucl Med,2013,38(5):332-338.
[12]	[12]BISCHOFF L A,CURRY J,AHMED I,et al.Is above age45 appropriate for upstaging well-differentiated papillary thyroid cancer[J].Endocr Pract,2013,19(6):995-997.
[13]	[13]ITO Y,KUDO T,KIHARA M,et al.Prognosis of low-risk papillary thyroid carcinoma patients:Its relationship with the size of primary tumors[J].Endocr J,2012,59(2):119-125.
[14]赵劼,孙辉,温强,等.分化型甲状腺癌术后131I清除剩余甲状腺及治疗甲癌转移灶的临床作用[J].吉林医学.2006,27(2):117-118.
[15]关海霞,陆汉魁.分化型甲状腺癌的131I消融治疗[J].外科理论与实践.2012,17(01):15-16.
[16]张学东,李保军,赵现斌,等.甲状腺癌切除术后131I清除甲状腺残余组织疗效的相关因素分析[J].中国医药导报.2012,9(25):50-54.
[17]唐彩华,贾晓娟,许泽清.73例分化型甲状腺癌术后131I治疗随访结果分析[J].肿瘤学杂志,2014,20(01):72-74.
[18]黄勇,谢建平,李素平,等.131I甲状腺癌疗效的影响因素[J].川北医学院学报,2011,26(3):274-277.
[19]	[19]CIAPPUCCINI R,HARDOUIN J,HEUTTE N,et al.Stimulated thyroglobulin level at ablation in differentiated thyroid cancer:the impact of treatment preparation modalities and tumor burden[J].Eur J Endocrinol,2014,171(2):247-252.
[20]屈伟,丁石梅,王社教,等.术后分化型甲状腺癌131I清甲治疗疗效及影响因素分析[J].现代肿瘤医学,2013,21(10):2209-2211.
[20]余永利,罗全勇,陈立波,等.分化型甲状腺癌术后131I治疗对复发的影响[J].中华核医学杂志,2004,24(04):25-27.
[22]黄治文,肖欢,李诗运,等.131I治疗分化型甲状腺癌术后转移灶的疗效分析[J].海南医学,2011,22(10):67-68.
[23]陆汉魁,余永利,罗全勇,等.131I治疗分化型甲状腺癌合并远处转移的疗效及影响因素[J].上海第二医科大学学报,2005,25(12):1263-1266.
[24]	[24]TENG W P,LIU Y F,GAO M,et al.Chinese management guidelines for patients with thyroid nodules and differentiated thyroid cancer[J].Chin J Endocrinol Metab,2012,28(10):779-797.
[25]	[25]NIXON I J,WHITCHER M,PALMER F L,et al.The impact of distant metastases at presentation on prognosis in patients withdifferentiated carcinoma of the thyroid gland[J].Thyroid,2012,22(9):884-889.

Relative Articles(20)

Relative Articles

[1]	Fei SONG, Jiayin CHE, Ming HUANG, Dan XU, Hongyang LI, Dingkun LI, Yingying XIANG. The Role of Radioactive Iodine-125 Particles in EMT and Clinical Treatment of Lung Adenocarcinoma. Journal of Kunming Medical University, 2023, 44(1): 140-143. doi: 10.12259/j.issn.2095-610X.S20230101
[2]	Wei WANG, Qingxia YANG, Juanzhang LUO, Yahong WANG, Fuke WANG, Ruimei SUN. Efficacy of Transaxillary Approach Endoscopic Thyroid Surgery for the Treatment of Single-Sided Thyroid Cancer. Journal of Kunming Medical University, 2023, 44(12): 65-71. doi: 10.12259/j.issn.2095-610X.S20231211
[3]	Fei SONG, Yingying XIANG, Jiayin CHE, Hongyang LI, Wenyong XU, Lingxiao WEI, Ming HUANG. Clinical Comparison of Biliary Iodine-125 Stent and Bare Metal Stent in Treatment of Bismuth Corlette III Cholangiocarcinoma Complicated with Obstructive Jaundice. Journal of Kunming Medical University, 2022, 43(11): 85-89. doi: 10.12259/j.issn.2095-610X.S20221110
[4]	Xixiong SU, Wei XU, Liqi XU, Qin YANG, Yunli YANG. Effects of Percutaneous Transluminal Angioplasty Plus Open Operation in Hemodialysis Patients with Type I and II Upper Limb Arteriovenous Fistula Stenosis. Journal of Kunming Medical University, 2022, 43(6): 52-55. doi: 10.12259/j.issn.2095-610X.S20220626
[5]	Huajie WU, Nan ZHANG, Lei LI, Han QIAO, Guoping LI. Research Progress in the Risk Factors and Prevention Strategies of Thyroid Cancer. Journal of Kunming Medical University, 2022, 43(5): 162-167. doi: 10.12259/j.issn.2095-610X.S20220526
[6]	Feipeng WU, Yongqiang GAO, Liju HONG, Qiyan WU, Huijun CHENG, Jiaoxia LI, Youjun ZHOU, Xiandong ZHENG. The Correlation between The Thyroid Function and Renal Function in Patients with Differentiated Thyroid Cancer under the Short-term Hypothyroidism after Withdrawal of Iodine Therapy. Journal of Kunming Medical University, 2022, 43(1): 77-83. doi: 10.12259/j.issn.2095-610X.S20220128
[7]	Hong-ling SHI, Yu LI, Ting-juan ZHANG, Lei YANG, Bai-jing LIU, Feng-yun YANG, Yu-yun ZHAO, Ke-rong CHEN, Li-rong BI, Xiao-yu LI, Jia-pu WANG. Application of Innovative Teaching of “TBL，Workshop” in the Teaching of Speech Therapy. Journal of Kunming Medical University, 2021, 42(7): 157-160. doi: 10.12259/j.issn.2095-610X.S20210726
[8]	Zhang Hong , Fang Xing Bao , Xu Bin Yong , Wang Zhao Xiong , Ge Jia Yun . Application of Carbon Nano Negative Parathyroid Imaging in Thyroid Cancer Surgery. Journal of Kunming Medical University, 2017, 38(11): 58-61.
[9]	Li Lei , Yang Jie , Wang Wei Lin , Wang Hu . Surgical Treatment Strategy of Thyroid Carcinoma with Hashimoto's Thyroiditis. Journal of Kunming Medical University, 2017, 38(10): 95-100.
[10]	Li Si Qi , Wu Tao , Li Yan , Zhang Yi , Zhao Zhi Jing , Dong Li Ying , Liang Ying , Mao Ying , Ma Jun Feng . . Journal of Kunming Medical University, 2017, 38(02): 109-113.
[11]	Dong Lin , Wang Feng , Zhu Ting , Liu Jie , Zhang Wei , Meng Guo Liang . Comparison of the Clinical Efficacy of Iodine 131I and Antithyroid Drugs in Treatment of Hyperthyroidism. Journal of Kunming Medical University, 2017, 38(11): 104-106.
[12]	Hai Sai Ping , Yang Li Chun . A Retrospective Analysis of Ultrasonographic Misdiagnosis of Thyroid Multiple Nodules With Thyroid Carcinoma. Journal of Kunming Medical University, 2016, 37(11): 89-92.
[13]	Wang Xiu Hua . . Journal of Kunming Medical University,
[14]	He Jin . . Journal of Kunming Medical University,
[15]	Gong Jian Yu . . Journal of Kunming Medical University,
[16]	Nian Ying Hua . . Journal of Kunming Medical University,
[17]	Sun Rui Mei . . Journal of Kunming Medical University,
[18]	Xiong Yan . . Journal of Kunming Medical University,
[19]	. Parathyroid Glands Can Be Easily ldentified and Preserved by Activated Carbon Particles in Surgery of Thyroid Carcinoma. Journal of Kunming Medical University,
[20]	. Expression of Survivin in Differentiated Thyroid Carcinomas and Its Clinical Significance. Journal of Kunming Medical University,