HSF2 Promotes Heat Shock Protein Expression in Lung Cancer

Fan Min Juan; Zhong Yun Hua; Shen Wen; Yuan Kai Fen; Zhao Guo Hou; Wang Shu Kun; Wen Lin Qiao

Article Contents

Article Navigation > Journal of Kunming Medical University > 2017 > 38(06): 108-112

Fan Min Juan , Zhong Yun Hua , Shen Wen , Yuan Kai Fen , Zhao Guo Hou , Wang Shu Kun , Wen Lin Qiao . HSF2 Promotes Heat Shock Protein Expression in Lung Cancer[J]. Journal of Kunming Medical University, 2017, 38(06): 108-112.

Citation:

Fan Min Juan , Zhong Yun Hua , Shen Wen , Yuan Kai Fen , Zhao Guo Hou , Wang Shu Kun , Wen Lin Qiao . HSF2 Promotes Heat Shock Protein Expression in Lung Cancer[J]. Journal of Kunming Medical University, 2017, 38(06): 108-112.

Citation:

PDF( 1273 KB)

HSF2 Promotes Heat Shock Protein Expression in Lung Cancer

Funds:

基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2013FB197); 云南省教育厅科学研究基金资助项目 (2014Z066);

Received Date: 2017-03-14

Abstract

Abstract

Objective To explore the influence of HSF2 on occurrence of lung cancer and tumor cell proliferation by promoting HSP's expression. Me thods We selected the para-carcinoma tissue from patients with lung cancer, then constructed the eukaryoticvector of HSF2 overexpression, then respectively transfected into BEAS-2B and A549, in order to exam its influence on cell proliferation and HSP expression, and we co-transfected the si RNA of HSP27 and HSP90 while the transfection of p IRES2-EGFP-HSF2, in order to exam the influence on cell proliferation. Re s ults The overexpression of HSF2 may increase BEAS-2B, improve the A549 proliferation speed (P<0.01) and the expressions of HSP27, HSP90. The co-transfected si RNA of HSP27 and HSP90 may equally recede the cell proliferations of BEAS-2B and A549 induced by HSF2 (P <0.01) .Conclus ion The cell proliferation of lung cancer promoted by HSF2 may possibly be achieved through promoting the expression of HSP.
- Lung Cancer,
- HSF2,
- Heat Shock Protein,
- BEAS-2B,
- A549

FullText(HTML)

References(14)

References

[1]	[1]CHEN W, ZHENG R, BAADE P D, et al.Cancer statistics in China 2015[J].CA Cancer J Clin, 2016, 66 (2) :115-132.
[2]	[2]CIOCCA D R, CALDRWOOD S K.Heat shock proteins in cancer:diagnostic, prognostic, predictive, and treatment implications[J].Cell Stress Chaperones, 2005, 10 (2) :86-103.
[3]	[3]MURPHY M E.The HSP70familyand cancer[J].Carcinogenesis, 2013, 34 (6) :118l-1188.
[4]	[4]SHI Y, LIUX, LOU J, et al.Plasma levels of heatshock protein90 alpha associated with lungcancer development and treatment responses[J].Clin Cancer Res, 2014, 20 (23) :6016-6022.
[5]	[5]WU C.Heat shock transcription factors:structuer and regulation[J].Annu Rev Cell Biol, 1995, 11 (4) :441-469
[6]	[6]MORIMOTO R I.Regulation of the heat shock transcriptional response:cross talk between a family of heat shock factors molecular chaperones and negative regulators[J].Genes Dev, 1998, 12 (24) :3788-3796.
[7]	[7]ENGERUD H, TANGEN I L, BERG A, et al.High level of HSF1 associates with aggressive endometrial carcinoma and suggests potential for HSP90 inhibitors[J].Br J Cancer, 2014, 111 (1) :78-84.
[8]王明慧, 冯林, 李萍, 等.Hsp90AB1在非小细胞肺癌中高表达并且与肺腺癌患者不良预后相关[J].中国肺癌杂志, 2016, 19 (2) :64-69.
[9]钟云华, 范敏娟.HSF2基因在肺癌中的表达意义[J].中国民族民间医药, 2016, 25 (12) :177-180.
[10]	[10]LEI Y M, ZUY F, WANG J, et al.Interleukin-1betamediated suppression of micro RNA-101 and upregulation of enhancer of zeste homolog 2 is involved in particle-induced lung cancer[J].Med Oncol, 2015, 32 (1) 32:387.
[11]	[11]WILKERSON D C, SKAGGS H S, SARGE K D, et al.HSF2 binds to the Hsp90, Hsp27, and c-Fos promoters constitutively and modulates their expression[J].Cell Stress Chaperones, 2007, 12 (3) :283-290.
[12]	[12]BANERJI U, Heat shock protein 90 as a drug target:some kike ithot[J].Clin Cancer Res, 2009, 15 (1) :9-14.
[13]	[13]ZHANG S, HU Y, HUANG Y, et a1.Heat shock protein27promotes cellproliferation through activatorprotein-1in lung cancer[J].Oncol Lett, 2015, 9 (6) :2572-2576.
[14]	[14]MIAO J, NIU J, WANG K, et al.Heat shock factor 2 levels are associated with the severity of ulcerative colitis[J].PLo S One, 2014, 9 (2) :e88822.

Relative Articles(20)

Relative Articles

[1]	Ruicheng LI, Hongwei QIAN, Yanni FAN, Peipei ZHAO, Shan WEI, Huarong JING. Application of Logistic Regression and Artificial Neural Networks in the Differential Diagnosis of LC-MPE. Journal of Kunming Medical University, 2024, 45(10): 55-60. doi: 10.12259/j.issn.2095-610X.S20241009
[2]	Qun HUANG, Lili HOU, Degui WANG, Zhaojun WANG, Siyuan WU, Yingying SANG. The Effect of Active Circulatory Breathing Training in Patients undergoing Lung Cancer Surgery under 5A Mode. Journal of Kunming Medical University, 2024, 45(6): 190-196. doi: 10.12259/j.issn.2095-610X.S20240627
[3]	Hongbo ZHANG, Zhenlong LI, Ying LV, Yichao ZHANG, Xiangming QIU, Tingting HUANG. Comparison of Clinical Efficacy of Single-port and Double-port Video-assisted Thoracoscopic Lobectomy in the Treatment of Lung Cancer. Journal of Kunming Medical University, 2024, 45(4): 135-139. doi: 10.12259/j.issn.2095-610X.S20240419
[4]	Qianrong YANG, Xue CAO, Jiao YANG, Yanqiu ZHAO, Nan SHEN, Ya Jiao SUN. Status and Influencing Factors of Stigma in Lung Cancer Patients. Journal of Kunming Medical University, 2024, 46(): 1-8.
[5]	Jiang ZHANG, Xijuan ZHAO, Jiang WU, Bingkun YANG, Ni YANG, Liping ZHOU. Analysis of Frailty Status and Influencing Factors in Lung Cancer Patients Undergoing Radiotherapy. Journal of Kunming Medical University, 2024, 45(9): 1-8.
[6]	Ying WANG, Cong FU, Ying FU. Clinical Implications of Serum LDH，CysC，and PWR Level Detection in Lung Cancer Patients. Journal of Kunming Medical University, 2024, 45(4): 163-169. doi: 10.12259/j.issn.2095-610X.S20240424
[7]	Yajie SAI, Lvxin YAO, Ling CHENG, Li SHEN, Cailian QI, Zhaoxia WANG, Huatao NIU. Correlation Analysis between the Caregiver Burden and Life Meaning in Patients with the Early Diagnosis of Lung Cancer. Journal of Kunming Medical University, 2023, 44(9): 171-175. doi: 10.12259/j.issn.2095-610X.S20230906
[8]	Teng-fei ZHANG, Yue-feng HE, Lei ZHANG, Li ZHANG, Kai-yun YANG, Lian-qing LIU, Hui TAN. Expression of Long Non-coding RNA APTR，HEIH，FAS-ASA1，FAM83H-AS1，DICER1-AS1，PR-lncRNA in Lung Cancer. Journal of Kunming Medical University, 2021, 42(4): 49-52. doi: 10.12259/j.issn.2095-610X.S20210409
[9]	Chang LIU, Zhen-hua LI, Ying WANG, Yan-qin RUAN, Lai-hao QU, Ding-biao LI. Applications of Lung Cancer MDT Combined with PBL + CBL Model in the Clinical Teaching. Journal of Kunming Medical University, 2021, 42(9): 162-166. doi: 10.12259/j.issn.2095-610X.S20210911
[10]	Jiang ZHANG, Xi-juan ZHAO, Jiang WU, Yan LIU, Li-juan LI, Ye CHEN. Application of Family Empowerment Nursing Intervention Program in Patients with Lung Cancer Undergoing Radiotherapy. Journal of Kunming Medical University, 2021, 42(12): 169-176. doi: 10.12259/j.issn.2095-610X.S20211242
[11]	Ming-jie NING, Ying CHEN. Research Progress of The Correlation between Lung Microbiome and Lung Cancer. Journal of Kunming Medical University, 2021, 42(3): 155-160. doi: 10.12259/j.issn.2095-610X.S20210336
[12]	Li Meng Xian , Yu Jian Kun , Wen Yan Ping , Wu Han Xin , Gao Ling , Liu Xiao Xiao , Tai Wen Lin . . Journal of Kunming Medical University, 2020, 41(04): 51-55.
[13]	Zhao Min , Bi Jun Qiang , Zhou Yong Chun , Zhang Jin Ping , Luo Lei . Characteristics and Trends of Disease Constitution of 9553 Inpatients with Lung Cancer in Yunnan Province. Journal of Kunming Medical University, 2017, 38(04): 63-67.
[14]	Wang Hong . Role of Prostaglandin E2 in the Pathogenesis of COPD with Lung Cancer. Journal of Kunming Medical University,
[15]	He Xiao Yu . . Journal of Kunming Medical University,
[16]	Pan Long Fang . . Journal of Kunming Medical University,
[17]	Ma Jian Qiang . . Journal of Kunming Medical University,
[18]	Li Bin . . Journal of Kunming Medical University,
[19]	Li Bin . . Journal of Kunming Medical University,
[20]	Chen Jin Run . . Journal of Kunming Medical University,