Volume 38 Issue 06
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Article Navigation >  Journal of Kunming Medical University  > 2017  >  38(06): 108-112
Yiling ZUO, Jiayan SUN, Limei MING, Guilan ZHANG, Yunxia SHEN, Xiaolin ZHANG. The Health Education Based on Cognitive Behavioral Therapy in Patients with Colorectal Cancer during the Chemotherapy Intervals and Its Application in the Virtual Community Nursing[J]. Journal of Kunming Medical University, 2024, 45(11): 174-180. doi: 10.12259/j.issn.2095-610X.S20241125
Citation: Fan Min Juan , Zhong Yun Hua , Shen Wen , Yuan Kai Fen , Zhao Guo Hou , Wang Shu Kun , Wen Lin Qiao . HSF2 Promotes Heat Shock Protein Expression in Lung Cancer[J]. Journal of Kunming Medical University, 2017, 38(06): 108-112.
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HSF2 Promotes Heat Shock Protein Expression in Lung Cancer

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基金： 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2013FB197); 云南省教育厅科学研究基金资助项目 (2014Z066);

  • Received Date: 2017-03-14
    Abstract
  • Objective To explore the influence of HSF2 on occurrence of lung cancer and tumor cell proliferation by promoting HSP's expression. Me thods We selected the para-carcinoma tissue from patients with lung cancer, then constructed the eukaryoticvector of HSF2 overexpression, then respectively transfected into BEAS-2B and A549, in order to exam its influence on cell proliferation and HSP expression, and we co-transfected the si RNA of HSP27 and HSP90 while the transfection of p IRES2-EGFP-HSF2, in order to exam the influence on cell proliferation. Re s ults The overexpression of HSF2 may increase BEAS-2B, improve the A549 proliferation speed (P<0.01) and the expressions of HSP27, HSP90. The co-transfected si RNA of HSP27 and HSP90 may equally recede the cell proliferations of BEAS-2B and A549 induced by HSF2 (P <0.01) .Conclus ion The cell proliferation of lung cancer promoted by HSF2 may possibly be achieved through promoting the expression of HSP.
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    • References(14)
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