Staging Diagnosis of Endometrial Cancer by CT plus MRI and the Postoperative Level of VEGF-C

Dang Yong; Duan Zhao

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Dang Yong , Duan Zhao . Staging Diagnosis of Endometrial Cancer by CT plus MRI and the Postoperative Level of VEGF-C[J]. Journal of Kunming Medical University, 2017, 38(06): 124-129.

Citation:

Dang Yong , Duan Zhao . Staging Diagnosis of Endometrial Cancer by CT plus MRI and the Postoperative Level of VEGF-C[J]. Journal of Kunming Medical University, 2017, 38(06): 124-129.

Dang Yong , Duan Zhao . Staging Diagnosis of Endometrial Cancer by CT plus MRI and the Postoperative Level of VEGF-C[J]. Journal of Kunming Medical University, 2017, 38(06): 124-129.

Citation:

Dang Yong , Duan Zhao . Staging Diagnosis of Endometrial Cancer by CT plus MRI and the Postoperative Level of VEGF-C[J]. Journal of Kunming Medical University, 2017, 38(06): 124-129.

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Staging Diagnosis of Endometrial Cancer by CT plus MRI and the Postoperative Level of VEGF-C

Dang Yong ¹,
Duan Zhao ²

Funds:

基金：陕西省自然科学基金资助项目 (2013JM4012);

Received Date: 2017-03-10

Abstract

Abstract

Objective To explore the clinical application value of CT plus MRI in the staging diagnosis of endometrial cancer, and to evaluate the malignancy of cancer according to the postoperative level of VEGF-C.Me thods A total of 70 pathologically conformed endometrial cancercases were randomly selected. All patients underwent CT, MRI, and CT plus MRI examinations. Based on the staging confirmed by surgery, the accuracy rates of diagnosis of CT, MRI, and CT plus MRI were compared. The level of postoperative VGEF-C was observed to determine the malignancy of the cancer.Re s ults The accuracy rate of diagnosis of CT, MRI, and CT plus MRI before surgery was 59.4%, 65.7% and 92.1%, respectively. The rate of CT plus MRI was significantly higher than the rate of the other two examinations (P<0.05) . In addition, There was significant difference in the level of VEGF-C between endometrial cancers of differentstages. A positive correlation was observed between preoperative staging determined by CT plus MRI examination and the level of VEGF-C. Conclus ion CT plus MRI examination can produce high accuracy rate of staging diagnosis, which is positively correlated with the postoperative level of VEGF-C. Therefore, CT plus MRI examinationcan predict the malignancy of endometrial cancer, which is helpful for the clinical assessment and prognosis of endometrial cancer.
- Endometrial cancer,
- CT,
- MRI,
- Staging diagnosis,
- VEGF-C

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References(19)

References

[1]徐玮, 王娟, 徐妍力, 等.RNA干扰抑制EGFR基因表达对子宫内膜癌细胞上皮间质转化的影响[J].上海交通大学学报:医学版, 2013, 33 (4) :415-420.
[2]徐燕颖, 尹利荣, 杨维娜, 等.老年子宫内膜癌组织中ER、PR的表达及临床意义[J].中国老年学杂志, 2013, 33 (8) :1739-1740.
[3]黄忠华, 周均宗, 谢春燕, 等.多层螺旋CT三期增强扫描在诊断早期子宫内膜癌中的应用[J].中外医学研究, 2014, 08 (9) :55-56.
[4]康洁, 刘亚静, 高志红, 等.MR I和CT增强结合对子宫内膜癌术前分期的应用[J].河北医药, 2014, 24 (18) :2801-2802.
[5]卢瑞沾, 张俊成, 梁燕滨.子宫内膜癌的MRI动态增强特征[J].中国CT和MRI杂志, 2014, (1) :89-93.
[6] 俞丽, 宋迪.C T和MRI联合检查于晚期子宫内膜癌术前分期的价值[J].中国妇幼健康研究, 2013, 12 (6) :943-945.
[7]廖瑜, 黎清, 李依芬, 等.子宫内膜癌临床及MR I分期与手术病理分期的对比研究[J].广东医学, 2012, 33 (4) :472-473.
[8]	[8]CELIC C, OZDEMIR S, KIRESI D, et al.Evaluation of cervical involvement in endometrial cancer by transvaginalsonograghy, magnetic resonance imaging and frozen section[J].J Obstet Gynecol 2010, 30 (3) :302-307.
[9]曹廷志, 昊元赭, 张宗军, 等.CT和MRI联合检查在晚期子宫内膜癌术前分期中的价值[J].2011, 03 (24) :1008-8199.
[10]曲芄苋, 焦书竹.子宫内膜癌的治疗进展[J].国外医学妇产科学分册, 1999, 26 (4) :4.
[11]唐勇军.CT和MRI联合检查在晚期子宫内膜癌术前分期中的价值[J]影像技术, 2013, 3 (22) :1001-0270.
[12]陈晶晶, 陈柯, 王晓秋, 等.子宫内膜癌组织中Id-1、VEGF-C和EGFR的表达及临床意义[J].2010, 26 (2) :1001-7399.
[13]李雪丹, 佟晓光, 刘屹等.磁共振成像在子宫内膜癌术前分期及肌层浸润深度判定中的作用 (依照新修订的FIGO分期系统) [J].现代肿瘤医学, 2011, 19 (12) :2511-2514.
[14]李春元.磁共振成像对子宫内膜癌术前分期评估及术式选择的意义[J].现代中西医结合杂志, 2014, 03 (09) :3733-3735.
[15]陈宇, 吴永彦, 张娴.子宫内膜癌18例CT影像学表现[J].贵州医药, 2011, 35 (4) :369-370.
[16]俞丽, 宋迪.CT和MRI联合检查于晚期子宫内膜癌术前分期的价值[J].中国妇幼健康研究, 2013, 34 (06) :1673-5293.
[17]曹世姣, 张广亮, 喻芳, 等.子宫内膜癌中el F4E与VEGF的表达及其临床意义[J].中国癌症杂志, 2012, 22 (2) :120-124.
[18]董莉莳, 王海琳.STAT3及VEGF在子宫内膜癌组织中的表达研究[J].中国妇幼保健, 2013, 23 (33) :4762-4764.
[19]王明磊, 程敬亮.子宫内膜癌DCE-MRI联合DWI成像与VEGF-C表达相关性[J].2014, 35 (12) :1673-3422.

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