Correlation between Hepatic Pathohistology of Biopsies and Clinical Indices in Patients with HIV/HCV Co-infection

Zhou Wen Jing; Liu Jun; Bai Jing Song; Tian Bo; Jin Yong Mei; Tao Jian; Li Zhong Xi; Chen Jian Hua

Volume 38 Issue 06

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Zhou Wen Jing , Liu Jun , Bai Jing Song , Tian Bo , Jin Yong Mei , Tao Jian , Li Zhong Xi , Chen Jian Hua . Correlation between Hepatic Pathohistology of Biopsies and Clinical Indices in Patients with HIV/HCV Co-infection[J]. Journal of Kunming Medical University, 2017, 38(06): 136-139.

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Correlation between Hepatic Pathohistology of Biopsies and Clinical Indices in Patients with HIV/HCV Co-infection

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基金：昆明市科技局科研基金资助项目 (2016-S-03134);

Received Date: 2017-04-20

Abstract

Abstract

Objective To investigate the correlation between liver tissue inflammation and fibrosis degrees and CD4+ T-lymphocytes level in the patients with HCV/HIV co-infection. Me thods The relationship between liver biopsy histological inflammatory grade and fibrosis stage, liver function (ALT, AST, TBIL and ALB) , CD4+ T-lymphocytes level of 50 cases HCV/HIV co-infection patients was analyzed. Re s ults There were 47 cases (94%) with liver tissue inflammatory grade G2, and 45 cases (90%) for fibrosis stage S2. Whether liver function was normal or not, most of the patients presented with severe liver tissue inflammatory and fibrosis. There were no distinct differences in serum levels of ALT, AST, TBIL and ALB between inflammatory grade and fibrosis stage (P>0.05) . There were distinct differences on inflammatory grade and fibrosis stage between CD4≤200 cell/mm3 and CD4 ≤200 cell/mm3 group (P <0.05) . Conclus ions Liver biopsy is indispensable for confirming liver inflammatory staging and fibrotic scoring grading. Most of the patients with HCV/HIV co-infection present needing anti-HCV therapy. The CD4+T-lymphocytes level of patients could be a sensitive index for the estimation of the severity of liver damage.
- HIV,
- HCV,
- Co-infection,
- Liver biopsy,
- Pathohistology,
- Function,
- CD4+ T-lymphocyte

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References

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