武汉地区123例冠心病患者CYP2C19基因多态性分布

Li Lin; Li Ji Yi; Wang De Zhao; Liu Wei

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Li Lin , Li Ji Yi , Wang De Zhao , Liu Wei . 武汉地区123例冠心病患者CYP2C19基因多态性分布[J]. Journal of Kunming Medical University, 2017, 38(06): 60-63.

Citation:

Li Lin , Li Ji Yi , Wang De Zhao , Liu Wei . 武汉地区123例冠心病患者CYP2C19基因多态性分布[J]. Journal of Kunming Medical University, 2017, 38(06): 60-63.

Li Lin , Li Ji Yi , Wang De Zhao , Liu Wei . 武汉地区123例冠心病患者CYP2C19基因多态性分布[J]. Journal of Kunming Medical University, 2017, 38(06): 60-63.

Citation:

Li Lin , Li Ji Yi , Wang De Zhao , Liu Wei . 武汉地区123例冠心病患者CYP2C19基因多态性分布[J]. Journal of Kunming Medical University, 2017, 38(06): 60-63.

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武汉地区123例冠心病患者CYP2C19基因多态性分布

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基金：北京市优秀青年基金资助项目 (2011D008017000002);

Received Date: 2017-04-03

Abstract

Abstract

目的探讨武汉地区冠心病患者药物代谢酶CYP2C19基因多态性的分布.方法采用基因芯片法对123例服用氯吡格雷的无血缘关系的冠心病患者进行CYP2C19基因分型, 分析其基因型及代谢表型的分布, 并与文献报道中中国汉族人群进行比较.结果共统计发现5种基因型, 3种代谢表型;检测出快代谢型 (EM) 患者38例, 所占比例为30.9%, 检测出中间代谢型 (IM) 患者69例, 所占比例为56.1%, 检测出慢代谢型 (PM) 患者16例, 所占比例为13.0%.武汉地区冠心病患者中, CYP2C19基因代谢表型分布与文献报道无统计学意义 (P>0.05) .结论武汉地区冠心病患者中, CYP2C19基因存在多态性, 基因频率及代谢型分布频率与国内其他地区相一致.
- Coronary heart disease,
- Polymorphism of CYP2C19 gene,
- Distribution of metabolic phenotype,
- Clopidogrel

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References(20)

References

[1]	[1]NGUYEN T A, DIODATI I G, PHARAND C, et al.Resistance to clopidogrel:a review of the evidence[J].J Am Coil Cardiol, 2005, 1945 (8) :l157-1164.
[2]	[2]MEGA J L, CLOSE S L, WIVIOTT S D, et al.Cytochrome P-450 polymorphisms and Response to clopidogrel[J].N Engl J Med, 2009, 360 (4) :354-362.
[3]	[3]DICK R J, DEAR A E, BYRON K A.Clopidogrel resistance:Case reports of CYP2C19 gene variants in suspected coronary stent thrombosis[J].Heart Lung Circ, 2011, 20 (10) :657-658.
[4]	[4]AUNE B, BOURBIGOT J, DEROST J, et al.Bleeding and Resistance[J].BMJ, 2009, 338:b1927.
[5]	[5]ANQIOLILLO D J, SURYADEVARA S.Aspirin and clopidogrel:Efficacy and resistance in diabetes mellitus[J].Best Pract Res Clin Endocrinol Metab, 2009, 23 (3) :375-388.
[6]郑露, 邵建国.CYP2C19的基因多态性与临床[J].第二军医大学学报, 2008, 28 (11) :1262-1265.
[7]周健, 吕虹, 康熙雄.中国汉族人群不同性别、年龄、体重指数之间细胞色素氧化酶CYP2C19基因多态性的检测[J].中国临床药理学与治疗学, 2007, 12 (2) :208-213.
[8] 尚鹏超.豫东南人群不同性别、年龄、体量指数CYP2C19基因多态性分析[J].中国基层医药, 2015, 22 (12) :3276-3279.
[9]	[9]HARMSZE A, WERKUM J W, BOUMAN H J, et al.Besides CYP2C192, the variant allele CYP2C193 is associated with higher onclopidogrel platelet reactivity in patients on dual antiplatelet therapy undergoing elective coronary stent implantation[J].Pharmacogenet Genomics, 2010, 20 (1) :18-25.
[10]	[10] LEE J B, LEE K A, LEE K Y.Cytochrome P4502C19polymorphismis associated with reduced clopidogrel response in cerebrovascular disease[J].Yonsei Med J.2011, 52 (5) :734-738.
[11]	[11]SUBRAJA K, DKHAR S A, PRIYADHARSINIR, et al.Genetic polymorphism of CYP2C19 influences the response to clopidogrel in ischemic heart disease patients in the South Indian Tamilian population[J].Eur J Clin Pharmaco1, 2013, 69 (3) :415-422.
[12]	[12]HWANG S J, JEONG Y H, KIMI S, et al.The cytochrome2C192 and3 alleles attenuate response to clopidogrel similarly in East Asian patients undergoing elective percutaneous coronary intervention[J].Thromb Res, 2011, 127 (1) :23-28.
[13]	[13]KIM I S, CHOI B R, JEONG Y H, et al.The CYP2C192and CYP2Cl93 polymorphisms are associated with high post treatment platelet reactivity in Asian patients with acute coronary syndrome[J].J Thromb Haemost, 2009, 7 (5) :897-899.
[14]	[14] SIMON T, VERSTUYFT C, MARYKRAUSE M, et al.Genetic determinants of response to clopidogrel and cardiovascular events[J].N Engl J Med, 2009, 360 (4) :363-375.
[15]	[15]MEGA J L, CLOSE S L, WIVIOTT S D, et al.Cytochrome P450 genetic polymorphisms and the response to prasugrel:relationship to pharmacokinetic, pharmacodynamic, andclinicaloutcomes[J].Circulation, 2009, 119 (19) :2553-2560.
[16]	[16]MEGA J L, SIMON T, COLLET J P, et al.Reduced Function CYP2C19 Genotype and Risk of Adverse Clinical Outcomes Among Patients Treated with Clopidogrel Predominantly for PCI:A Meta Analysis[J].JAMA, 2010, 304 (16) :1821-1830.
[17]	[17]LIANG Z Y, HAN Y L, ZHANG X L, et al.The impact of gene polymorphism and high on treatment platelet reactivity on clinical follow up:outcomes in patients with acute coronary syndrome after drug eluting stent implantation[J].Euro Intervention, 2013, 9 (3) :316-327.
[18]	[18]MICHAEL M, MARK F, CARMEN D M, et al.enetic variation in metabolizing enzyme and transporter genes:comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans[J].J Clin Pharmacol, 2010.50 (8) :929-940.
[19]	[19]JIANG D C, BAI X G, ZHANG Q X, et al.Effects of CYP2C19 and CYP2C9 genotypes on pharmacokinetic variability of valproic acid in Chinese epileptic patients:nonlinear mixed-effect modeling[J].Eur J Clin Pharmacol, 2009, 65 (12) :1187-1193.
[20]	CHEN L L, QIN S Y, XIE J, et al.Genetic polymorphism analysis of CYP2C19 in Chinese Han populations from different geographic areas of Mainland of China[J].Pharmacogenomics, 2008, 9 (6) :691-702.

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