Effect of Osteoking on Blood Biochemical Indicator of Tree Shrew with Osteoporotic Fracture

Yuan Xin; Zheng Hong; Jiao Jian Lin; Wu Chao; Zhao Hong Bin; Tang Wei

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Yuan Xin , Zheng Hong , Jiao Jian Lin , Wu Chao , Zhao Hong Bin , Tang Wei . Effect of Osteoking on Blood Biochemical Indicator of Tree Shrew with Osteoporotic Fracture[J]. Journal of Kunming Medical University, 2017, 38(07): 12-15.

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Yuan Xin , Zheng Hong , Jiao Jian Lin , Wu Chao , Zhao Hong Bin , Tang Wei . Effect of Osteoking on Blood Biochemical Indicator of Tree Shrew with Osteoporotic Fracture[J]. Journal of Kunming Medical University, 2017, 38(07): 12-15.

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Effect of Osteoking on Blood Biochemical Indicator of Tree Shrew with Osteoporotic Fracture

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基金：国家自然科学基金资助项目 (81460647); 云南省应用基础研究计划项目 (2012 FB022, 2014FB033);

Received Date: 2017-04-14

Abstract

Abstract

Objective To observe the effect of Osteoking on blood biochemicalindicator of tree shrews with osteoporotic fracture (OPF) .Methods Totally 30 female tree shrews (Tupaiabelangeri) were randomly divided into the treatment group, the model group, and the control group, with 10 in each group. Bilateral ovaries and uterus were ectomized for 6 months in the treatment group and the model group, and right fibula fractures were induced after confirmed osteoporosis. Tree shrews in the treatment group were administered with Osteoking by gastrogavage, once per two days. Equal volume of normal saline was given to tree shrews in the model group and control group. Blood biochemical indexes were detected at 3 months after fracture.Results Compared with those in the control group, serum creatine kinase isoenzyme (CK-MB) , alanine aminotransferase (ALT) , magnesium (Mg2+) levels significantly increased (P<0.01) while total cholesterol (CHOL) and blood glucose (Glu) levels were significantly decreased (P<0.01) in the OPF model group. Compared with those in the model group, serum CK-MB and ALT significantly decreased (P<0.01) and Mg2+ significantly decreased (P<0.05) while CHOL and Glu significantly increased (P<0.05) in the treatment group. Conclusion Osteoking can protect the heart and liver function of tree shrew with osteoporotic fracture.
- Blood biochemical indicator,
- Osteoking,
- Tree shrews,
- Osteoporotic fracture

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References(22)

References

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