Li Ting , Bian Li . Related Research and Development MicroRNAs in Lung Cancer[J]. Journal of Kunming Medical University, 2017, 38(07): 130-135.
Citation: Li Ting , Bian Li . Related Research and Development MicroRNAs in Lung Cancer[J]. Journal of Kunming Medical University, 2017, 38(07): 130-135.

Related Research and Development MicroRNAs in Lung Cancer

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基金: 国家自然科学基金资助项目 (81460355, 2014FB020);

  • Received Date: 2017-04-13
  • MicroRNAs (miRNAs) is a class of small molecule non-protein-coding RNA, approximately 18 to 25 nt long. MiRNAs can act as endogenous RNA interference by regulating gene expression and translation at the posttranscriptional level. MiRNAs plays an important role in cell proliferation, apoptosis and tumorigenesis and development of a variety of physiological and pathological processes. In recent years, many studies have shown that miRNAs not only can be used as biomarkers for early diagnosis of lung cancer but also be involved in effective target for targeted therapy.
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  • [1]
    [1]YAN L, XU L.Global efforts in conquering lung cancer in China[J].Chin J Cancer, 2015, 34 (7) :320-322.
    [2]
    [2]LEE R C, FEINBAUM R L, AMBROS V, The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J].Cell, 1993, 75 (5) :843-854.
    [3]
    [3]KANG S M, LEE H I.Mirco RNA in human lung cancer[J].Exp Biol Med (Maywood) , 2014, 239 (11) :1505-1513.
    [4]黄云超.肺癌诊疗技术新进展[J].昆明医科大学学报, 2012, 33 (5) :1-3.
    [5]马卿鑫, 和海玉, 张鲁雄, 等.mi RNA-192在人体手术切除肺癌组织中的表达及临床意义研究[J].昆明医科大学学报, 2016, 37 (1) :73-76.
    [6]
    [6]LIN P Y, YU S L, YANG P C.Micro RNA in lung cancer[J].Br J Cancer, 2010, 103 (8) :1144-1148.
    [7]
    [7]JOSHI P, MIDDLETON J, JEON Y J, et al.Micro RNAs in lung cancer[J].World J Methodol, 2014, 4 (2) :59-72.
    [8]
    [8]GAROFALO MLGG.mi R-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation[J].Cancer Cell, 2009, 6 (16) :498-509.
    [9]
    [9]SEIKE M, GOTO A, OKANO T, et al.Mi R-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers[J].Proc Natl Acad Sci U S A, 2009, 106 (29) :12085-12090.
    [10]
    [10]RAMSHANKAR V, KRISHNAMURTHY A.Lung cancer detection by screening-presenting circulating mi RNAs as a promising next generation biomarker breakthrough[J].Asian Pac J Cancer Prev, 2013, 14 (4) :2167-2172.
    [11]
    [11]WANG H.Predicting Micro RNA Biomarkers for Cancer Using Phylogenetic Tree and Microarray Analysis[J].Int J Mol Sci, 2016, 17 (5) :773-786.
    [12]
    [12]LEBANONY D, BENJAMIN H, GILAD S, et al.Diagnostic assay based on hsa-mi R-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma[J].J Clin Oncol, 2009, 27 (12) :2030-2037.
    [13]
    [13]WANG H, WU S, ZHAO L, et al.Clinical use of micro RNAs as potential non-invasive biomarkers for detecting non-small cell lung cancer:a meta-analysis[J].Respirology, 2015, 20 (1) :56-65.
    [14]
    [14]ULIVI P, ZOLI W.mi RNAs as non-invasive biomarkers for lung cancer diagnosis[J].Molecules, 2014, 19 (6) :8220-8237.
    [15]
    [15]KLOPFLEISCH R, WEIISS A T, GRUBER AD.Excavation of a buried treasure-DNA, m RNA, mi RNA and protein analysis in formalin fixed, paraffin embedded tissues[J].Histol Histopathol, 2011, 26 (6) :797-810.
    [16]陆斌, 李建武, 杨艳.骨肉瘤患者血浆中micro RNA-181b水平的检测[J].昆明医科大学学报, 2015, 36 (9) :54-57.
    [17]张晓娟, 董静, 马红霞, 等.血清/血浆micro RNA检测方法探讨与建立[J].南京医科大学学报 (自然科学版) , 2011, 31 (4) :529-531.
    [18]
    [18]HALVORSEN A R, BJAAN S M, LEBLANC M, et al.A unique set of 6 circulating micro RNAs for early detection of non-small cell lung cancer[J].Oncotarget, 2016, 7 (24) :37250-37259.
    [19]
    [19]SHEN Y, WANG T, YANG T, et al.Diagnostic value of circulating micro RNAs for lung cancer:a meta-analysis[J].Genet Test Mol Biomarkers, 2013, 17 (5) :359-366.
    [20]
    [20]RAZZAK R, BDARD E L, KIM J O, et al.Micro RNA expression profiling of sputum for the detection of early and locally advanced non-small-cell lung cancer:a prospective case-control study[J].Curr Oncol, 2016, 23 (2) :e86-94.
    [21]
    [21]BARGER J F, NANA-SINKAM S P.Micro RNA as tools and therapeutics in lung cancer[J].Respir Med, 2015, 109 (7) :803-812.
    [22]
    [22]SHEN Z, WU X, WANG Z, et al.Effect of mi R-18a overexpression on the radiosensitivity of non-small cell lung cancer[J].Int J Clin Exp Pathol, 2015, 8 (1) :643-648.
    [23]
    [23]LIU G, LI YI, GAO X.Overexpression of micro RNA-133b sensitizes non-small cell lung cancer cells to irradiation through the inhibition of glycolysis[J].Oncol Lett, 2016, 11 (4) :2903-2908.
    [24]
    [24]GROSSO S, DOYEN J, PARKS S K, et al.Mi R-210promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines[J].Cell Death Dis, 2013, 4 (3) :e544-556.
    [25]
    [25]ZHANG J, ZHANG C, HU L, et al.Abnormal Expression of mi R-21 and mi R-95 in Cancer Stem-Like Cells is Associated with Radioresistance of Lung Cancer[J].Cancer Invest, 2015, 33 (5) :165-171.
    [26]
    [26]TIAN F, HAN Y, YAN X, et al.Upregulation of microrna-451 increases the sensitivity of A549 cells to radiotherapy through enhancement of apoptosis[J].Thorac Cancer, 2016, 7 (2) :226-231.
    [27]
    [27] JIANG Y W, CHEN L A.micro RNAs as tumor inhibitors, oncogenes, biomarkers for drug efficacy and outcome predictors in lung cancer (review) [J].Mol Med Rep, 2012, 5 (4) :890-894.
    [28]
    [28]WU L, PU X, WANG Q, et al.mi R-96 induces cisplatin chemoresistance in non-small cell lung cancer cells by downregulating SAMD9[J].Oncol Lett, 2016, 11 (2) :945-952.
    [29]
    [29]CHEN Q Y, JIAO DM, WANG J, et al.mi R-206 regulates cisplatin resistance and EMT in human lung adenocarcinoma cells partly by targeting MET[J].Oncotarget, 2016, 7 (17) :24510-24526.
    [30]
    [30]LUO W, LIN Y, MENG S, et al.mi RNA-296-3p modulates chemosensitivity of lung cancer cells by targeting CX3CR1[J].Am J Transl Res, 2016, 8 (4) :1848-1856.
    [31]熊新明, 刘英.mirna在肺癌诊断和治疗中的研究进展[J].实用医学杂志, 2011, 27 (24) :4358-4360.
    [32]
    [32]GAROFALO M, ROMANO G, DI L G, et al.EGFR and MET receptor tyrosine kinase-altered micro RNA expression induces tumorigenesis and gefitinib resistance in lung cancers[J].Nat Med, 2012, 18 (1) :74-82.
    [33]
    [33]JIANG Y W, CHEN L A.micro RNAs as tumor inhibitors, oncogenes, biomarkers for drug efficacy and outcome predictors in lung cancer (review) [J].Mol Med Rep, 2012, 5 (4) :890-894.
    [34]
    [34]MOMI N, KAUR S, RACHAGANI S, et al.Smoking and micro RNA dysregulation:a cancerous combination[J].Trends Mol Med, 2014, 20 (1) :36-47.
    [35]
    [35]DEL V V, GRASSO M, BARBARESCHI M, et al.Micro RNAs as lung cancer biomarkers[J].World J Clin Oncol, 2014, 5 (4) :604-620.
    [36]
    [36]BOERI M, VERRI C, CONTE D, et al.Micro RNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer[J].Proc Natl Acad Sci U S A, 2011, 108 (9) :3713-3718.
    [37]
    [37]LI X, SHI Y, YIN Z, et al.An eight-mi RNA signature as a potential biomarker for predicting survival in lung adenocarcinoma[J].J Transl Med, 2014, 12 (1) :159.
    [38]
    [38]CHEN W J, ZHANG E N, ZHONG Z K, et al.Micro RNA-153 expression and prognosis in non-small cell lung cancer[J].Int J Clin Exp Pathol, 2015, 8 (7) :8671-8675.
    [39]
    [39]WANG Z, CHEN Z, GAO Y, et al.DNA hypermethylation of micro RNA-34b/c has prognostic value for stageⅠnon-small cell lung cancer[J].Cancer Biol Ther, 2011, 11 (5) :490-496.
    [40]
    [40]ZHAO J, WANG K, LIAO Z, et al.Promoter mutation of tumor suppressor micro RNA-7 is associated with poor prognosis of lung cancer[J].Mol Clin Oncol, 2015, 3 (6) :1329-1336.
    [41]CHO WCS, 丁燕, 南娟.Mi RNA作为肺癌分子诊断工具的前景与挑战[J].中国肺癌杂志, 2012, 5 (2) :127-129.
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