Liu Hu Jun , Gao Li Ping . Influences of Different Doses of Ambroxol Hydrochloride Injection on Inflammatory Cytokines in Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease with Acute Exacerbation[J]. Journal of Kunming Medical University, 2017, 38(09): 119-123.
Citation: Liu Hu Jun , Gao Li Ping . Influences of Different Doses of Ambroxol Hydrochloride Injection on Inflammatory Cytokines in Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease with Acute Exacerbation[J]. Journal of Kunming Medical University, 2017, 38(09): 119-123.

Influences of Different Doses of Ambroxol Hydrochloride Injection on Inflammatory Cytokines in Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease with Acute Exacerbation

Funds:

基金: 陕西省社会发展科技攻关项目 (2016SF-151);

  • Received Date: 2017-04-23
  • Objective To study the influences of different doses of Ambroxol Hydrochloride Injection on the inflammatory cotokines in the treatment of elderly patients with chronic obstructive pulmonary disease patients with acute exacerbation.Methods 62 cases of elderly patients with chronic obstructive pulmonary disease with acute exacerbation in our hospital from May 2015 to May 2016 were selected and randomly divided into Group A and B, 31 cases in each group.The Group A was given Ambroxol Hydrochloride Injection treatment, 330 mg per time, and Group B was given 90 mg Ambroxol Hydrochloride Injection treatment.The IL-6, IL-8, and TNF-α Index on the1 st day, 4 th day and 7 th day after the treatment in these two groups were compared.Results On the 1 st day, the sputum IL-6, IL-8 and TNF-αafter treatment had no statistically significant difference between two groups (P>0.05) .On the first 4 th day and 7 th day, the decrease of the indicators of patients in A group was significantly better than group B patients, and the difference was statistically significant (P<0.05) .There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05) .Conclusion The application of large doses of short Ambroxol Hydrochloride Injection can quickly improve the clinical symptoms in acute exacerbation of elderly patients with chronic obstructive pulmonary disease, and reduce the patient's sputum IL-6, IL-8 and TNF-α index, has better anti-inflammatory effect and deserves wide application.
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  • [1]柴燕玲, 王颖, 雷雯, 等.慢性阻塞性肺疾病继发肺部真菌感染相关因素分析[J].昆明医科大学学报, 2007, 28 (4) :141-142.[1]柴燕玲, 王颖, 雷雯, 等.慢性阻塞性肺疾病继发肺部真菌感染相关因素分析[J].昆明医科大学学报, 2007, 28 (4) :141-142.
    [2]唐朝晖, 李永兰, 孟英龙, 等孟鲁斯特治疗对慢阻肺患者肺功能及Th1、Treg平衡的调节作用[J].湖南师范大学学报 (医学版) , 2016, 13 (1) :74-76.[2]唐朝晖, 李永兰, 孟英龙, 等孟鲁斯特治疗对慢阻肺患者肺功能及Th1、Treg平衡的调节作用[J].湖南师范大学学报 (医学版) , 2016, 13 (1) :74-76.
    [3]梅涛, 贾若飞, 阙思伟, 等.纤支镜下大剂量盐酸氨溴索注射液灌洗治疗高血压重度脑出血后肺部感染[J].中国医药导刊, 2014, 16 (11) :1369-1370.[3]梅涛, 贾若飞, 阙思伟, 等.纤支镜下大剂量盐酸氨溴索注射液灌洗治疗高血压重度脑出血后肺部感染[J].中国医药导刊, 2014, 16 (11) :1369-1370.
    [4]
    [4]CLARA E GREEN, ALICE M TURNER.Role of chronic obstructive pulmonary disease in lung cancer pathogenesis[J].World Journal of Respirology, 2013, 11 (3) :67-76.[4]CLARA E GREEN, ALICE M TURNER.Role of chronic obstructive pulmonary disease in lung cancer pathogenesis[J].World Journal of Respirology, 2013, 11 (3) :67-76.
    [5]
    [5]MASAKI FUJITA.New therapies for chronic obstructive pulmonary disease, lung regeneration[J].World Journal of Respirology, 2015, 12 (1) :34-39.[5]MASAKI FUJITA.New therapies for chronic obstructive pulmonary disease, lung regeneration[J].World Journal of Respirology, 2015, 12 (1) :34-39.
    [6]
    [6]YUICHI TAKIGUCHI, IKUO SEKINE, SHUNICHIRO IWASAWA, ect.Chronic obstructive pulmonary disease as a risk factor for lung cancer[J].World Journal of Clinical Oncology, 2014, 23 (4) :660-666.[6]YUICHI TAKIGUCHI, IKUO SEKINE, SHUNICHIRO IWASAWA, ect.Chronic obstructive pulmonary disease as a risk factor for lung cancer[J].World Journal of Clinical Oncology, 2014, 23 (4) :660-666.
    [7]胡晓慧.舒利迭联合噻托溴铵粉吸入剂对比舒利迭联合盐酸氨溴索注射液治疗慢性阻塞性肺疾病的临床疗效评价[J].中国煤炭工业医学杂志, 2015, 18 (11) :1859-1861.[7]胡晓慧.舒利迭联合噻托溴铵粉吸入剂对比舒利迭联合盐酸氨溴索注射液治疗慢性阻塞性肺疾病的临床疗效评价[J].中国煤炭工业医学杂志, 2015, 18 (11) :1859-1861.
    [8]苏学会, 赵萍, 胡江涛, 等.COPD有创机械通气时用盐酸氨溴索注射液静脉注射及雾化吸入祛痰的疗效观察[J].河北医药, 2011, 33 (24) :3763-3764.[8]苏学会, 赵萍, 胡江涛, 等.COPD有创机械通气时用盐酸氨溴索注射液静脉注射及雾化吸入祛痰的疗效观察[J].河北医药, 2011, 33 (24) :3763-3764.
    [9]陆首玲, 涂娟, 倪爱霞.异丙托溴铵、盐酸氨溴索注射液、普米克令舒联合雾化吸入治疗慢性阻塞性肺疾病急性加重期的疗效观察[J].现代诊断与治疗, 2014, 25 (13) :2959-2960.[9]陆首玲, 涂娟, 倪爱霞.异丙托溴铵、盐酸氨溴索注射液、普米克令舒联合雾化吸入治疗慢性阻塞性肺疾病急性加重期的疗效观察[J].现代诊断与治疗, 2014, 25 (13) :2959-2960.
    [10]胡静珊, 谭文惠, 杨静萍.氨溴索雾化联合机械辅助排痰预防脑卒中卧床患者并发肺炎的效果观察[J].中国医药指南, 2014, 12 (30) :174-175.[10]胡静珊, 谭文惠, 杨静萍.氨溴索雾化联合机械辅助排痰预防脑卒中卧床患者并发肺炎的效果观察[J].中国医药指南, 2014, 12 (30) :174-175.
    [11]
    [11]JUDITH A BREBNER, ALICE M TURNER.Early chronic obstructive pulmonary disease:Beyond spirometry[J].World Journal of Respirology, 2013, 29 (3) :57-66.[11]JUDITH A BREBNER, ALICE M TURNER.Early chronic obstructive pulmonary disease:Beyond spirometry[J].World Journal of Respirology, 2013, 29 (3) :57-66.
    [12]刘红梅, 马利军, 吴纪珍, 等.MSCs relieve lung injury of COPD mice through promoting proliferation of endogenous lung stem cells[J].Journal of Huazhong University of Science and Technology (Medical Sciences) , 2015, 22 (6) :828-833.[12]刘红梅, 马利军, 吴纪珍, 等.MSCs relieve lung injury of COPD mice through promoting proliferation of endogenous lung stem cells[J].Journal of Huazhong University of Science and Technology (Medical Sciences) , 2015, 22 (6) :828-833.
    [13]王煜, 苏南湘, 陈泽奇, 等.Effects of Fengbaisan (丰白散) on the expression of matrix metalloproteinase—9 and tissue inhibitor of metalloproteinase-1 in lung tissue of rats with chronic obstructive pulmonary disease[J].Chinese Journal of Integrative Medicine, 2014, 19 (3) :224-231.[13]王煜, 苏南湘, 陈泽奇, 等.Effects of Fengbaisan (丰白散) on the expression of matrix metalloproteinase—9 and tissue inhibitor of metalloproteinase-1 in lung tissue of rats with chronic obstructive pulmonary disease[J].Chinese Journal of Integrative Medicine, 2014, 19 (3) :224-231.
    [14]
    [14]JOS M BORRO, MAR A DELGADO, ELISABETH COLL, Salvador Pita.Single-lung transplantation in emphysema:Retrospective study analyzing survival and waiting list mortality[J].World Journal of Transplantation, 2016, 2 (28) :347-355.[14]JOS M BORRO, MAR A DELGADO, ELISABETH COLL, Salvador Pita.Single-lung transplantation in emphysema:Retrospective study analyzing survival and waiting list mortality[J].World Journal of Transplantation, 2016, 2 (28) :347-355.
    [15]古辉, 徐小彭.布地奈德氧气雾化吸入对慢阻肺急性发作期患者胸肺顺应性及气体交换参数的影响观察[J].临床医学工程, 2014, 21 (4) :461-462.[15]古辉, 徐小彭.布地奈德氧气雾化吸入对慢阻肺急性发作期患者胸肺顺应性及气体交换参数的影响观察[J].临床医学工程, 2014, 21 (4) :461-462.
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