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Wang Chun Long , Han Dan , Wen Liang . Research Progress of Mesothelin in Tumor Diagnosis and Treatment[J]. Journal of Kunming Medical University, 2017, 38(09): 134-139.
Citation: Wang Chun Long , Han Dan , Wen Liang . Research Progress of Mesothelin in Tumor Diagnosis and Treatment[J]. Journal of Kunming Medical University, 2017, 38(09): 134-139.
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Research Progress of Mesothelin in Tumor Diagnosis and Treatment

Funds:

基金： 国家自然科学基金资助项目 (81160179, 81160179); 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助助目 (2014FA013, 2009ZC100M);

  • Received Date: 2017-05-11
    Abstract
  • Mesothelin is a cell surface glycoprotein, with little expression in normal tissues, but highly expressed in tumors such as ovarian cancer, pancreatic cancer and malignant mesothelioma.Therefore, mesothelin helps those tumors' early diagnosis, and is related to tumor staging and prognosis.The use of immunotoxin, anti-mesothelin chimeric antibodies, antibody-drug conjugates, chimeric antigen receptor T cells, mesothelin tumor vaccines is progressing towards maturation in the treatment of mesothelin-rich tumors.This article aims to review the research progress of mesothelin in ovarian cancer, pancreatic cancer, malignant mesothelioma diagnosis and treatment.
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    • References(46)
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