Preparation and in Vitro Release Study of Panax Notoginseng Sustained-release Pellets

Ke Jin; Cheng Xin; Hou An Guo

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Ke Jin , Cheng Xin , Hou An Guo . Preparation and in Vitro Release Study of Panax Notoginseng Sustained-release Pellets[J]. Journal of Kunming Medical University, 2017, 38(09): 24-29.

Citation:

Ke Jin , Cheng Xin , Hou An Guo . Preparation and in Vitro Release Study of Panax Notoginseng Sustained-release Pellets[J]. Journal of Kunming Medical University, 2017, 38(09): 24-29.

Ke Jin , Cheng Xin , Hou An Guo . Preparation and in Vitro Release Study of Panax Notoginseng Sustained-release Pellets[J]. Journal of Kunming Medical University, 2017, 38(09): 24-29.

Citation:

Ke Jin , Cheng Xin , Hou An Guo . Preparation and in Vitro Release Study of Panax Notoginseng Sustained-release Pellets[J]. Journal of Kunming Medical University, 2017, 38(09): 24-29.

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Preparation and in Vitro Release Study of Panax Notoginseng Sustained-release Pellets

Funds:

基金：云南省自然科学基金资助项目 (2014ZF089);

Received Date: 2017-04-22

Abstract

Abstract

Objective To prepare Panax notoginseng (PNG) sustained-release pellets and accomplish in vitro release study.Methods Single-factor test and orthogonal test was used to establish the preparation of pellets.Coating conditions were investigated by single-factor test.In vitro release study was used to research the effects of different coating thickness.Results The preparation of pellets was (PNG) :Cellulose Microcrystalline (MCC) =1:3, 45% ethanol was Wetting Agent, method was extrusion-spheronization, rate of extrusion was 45 r/min, rolling rate was 35 HZ (1 505 r/min) , rolling time was 6 minutes, vacuum drying continued for 4 hours at 60℃.Orthogonal test indicated effect order was rolling rate>rolling time>extrusion tare.15% Surelease E-7-19050 was coated pellet at 40℃, the pressure of spray was 0.4 MPa, the rate of spray was 1.0 m L/min.The in vitro release study confirmed that pellets had released sustainedly with added 17% weight.The in vitro release data were well fitted to Higuchi drug release models.Conclusions The preparation process is simple and reliable and could be used to dig deeper to develop.It could lay the foundation for study of release mechanism further.
- Panax notoginseng,
- Sustained-release pellets,
- Extrusion-spheronization,
- Release determination

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References(17)

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