The Oxidation and Cytotoxic Activity Screening of Panaxadiol and Panaxatriol Derivatives

Zhao Yi Chun; Cao Qing Qing; Zou Cheng; Hu Jian Lin; Xu Li Li; Jin Jin; Zhao Qing

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Zhao Yi Chun , Cao Qing Qing , Zou Cheng , Hu Jian Lin , Xu Li Li , Jin Jin , Zhao Qing . The Oxidation and Cytotoxic Activity Screening of Panaxadiol and Panaxatriol Derivatives[J]. Journal of Kunming Medical University, 2017, 38(10): 11-15.

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Zhao Yi Chun , Cao Qing Qing , Zou Cheng , Hu Jian Lin , Xu Li Li , Jin Jin , Zhao Qing . The Oxidation and Cytotoxic Activity Screening of Panaxadiol and Panaxatriol Derivatives[J]. Journal of Kunming Medical University, 2017, 38(10): 11-15.

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The Oxidation and Cytotoxic Activity Screening of Panaxadiol and Panaxatriol Derivatives

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基金：国家自然科学基金资助项目 (81460533, 81160388); 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[ (2017FE468 (-001) ];

Received Date: 2017-04-21

Abstract

Abstract

Objective To study the synthesis of dammarane-type triterpene derivatives by using Panaxadiol and Panaxatriol as starting materials and screen their cytotoxic activity in vitro. Methods The products derived from PCC oxidation and DDQ oxidation of panaxadiol and panaxatriol, were further oxidized with m-chloroperoxybenzoic acid (m-CPBA) , as a result, four ring opening products were obtained, which were subjected to in vitro cytotoxic activity screening with MTT method. Results Four ring-opening derivatives were prepared (Compound2, 4, 6, 8) . Conclusion The four ring-opening derivatives are new compounds, and compound 2 and 4 show significant cytotoxicity against several cancer cell lines.
- Panax notoginseng,
- Panaxadiol,
- Panaxatriol

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References(11)

References

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