Pathological Morphology of 76 Cases of DCD Liver Transplantation

Objective To observe the pathological morphology changes of DCD donor liver, and to explore the application of DCD donor liver, especially steatosis, donor liver in allogeneic orthotopic liver transplantation (AOLT) . Methods 76 cases of DCD donor liver in AOLT were retrospectively studied, in which the grades of steatosis are classified as no steatosis (S0, n=36 cases) , mild (S1, n=21 cases) , moderate (S2, n= 14 cases) , and severe ones (S3 grade, n=5 cases) . The main influencing indexes of hepatic and renal function and the occurrence of early postoperative complications were observed at 3 days and 14 days after operation. Results Compared with the control group, the hepatic and renal function of S1 and S2 steathepatitis groups were not statistically significant at 3 days and 14 days after operation. The difference of the hepatic and renal function between S3 level and the control group was statistically significant. When compared with the control group, the incidence of complications of S1 and S2 group such as hemorrhage, infection, hepatic artery embolization, ascites and sepsis was not statistically significant (P>0.05) . There was statistically significant difference of the bleeding and infection, Hepatic artery embolism, ascites, sepsis and other complications between S3 level and the control group (P <0.05) . The survival rate of the patients in the 14 days postoperative was 94.4% in the control group and 90.5%, 85.7% and 60% in S1 group, S2 group and S3 group respectively. Conclusions Mild and moderate steatosis DCD donor liver can be used for transplantation in the case of careful selection. But it is difficult to overcome the risk factors for severe steatosis DCD donor liver for transplantation. So severe steatosis DCD donor liver should try to not to use.